Development Level

Tbio 13 | 11,178
Tchem 11 | 1,885
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17

Disease

Carcinoma 22 | 11,192
ovarian cancer 20 | 8,297
Cancer 19 | 2,388
osteosarcoma 16 | 7,766
Multiple myeloma 15 | 1,296
lung cancer 14 | 4,607
Schizophrenia 12 | 1,136
glioblastoma 12 | 5,635
psoriasis 12 | 6,514
atypical teratoid / rhabdoid tumor 11 | 4,971
medulloblastoma, large-cell 11 | 6,086
adult high grade glioma 10 | 3,701
ependymoma 10 | 4,559
Kidney cancer 9 | 2,548
malignant mesothelioma 9 | 3,135
primitive neuroectodermal tumor 9 | 2,957
subependymal giant cell astrocytoma 9 | 2,230
Breast cancer 8 | 3,469
Peripheral T-cell lymphoma 8 | 25
Primary cutaneous T-cell lymphoma 8 | 29
group 4 medulloblastoma 7 | 1,806
Pick disease 6 | 1,856
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
oligodendroglioma 6 | 2,768
Astrocytoma, Pilocytic 5 | 3,006
Frontal bossing 5 | 154
Mental Depression 5 | 325
astrocytic glioma 5 | 2,530
astrocytoma 5 | 1,113
group 3 medulloblastoma 5 | 4,002
Bowed and upward slanting eyebrows 4 | 39
Carcinoma, Squamous Cell 4 | 107
Epilepsy 4 | 775
Intellectual disability 4 | 998
Mood Disorders 4 | 181
Muscle hypotonia 4 | 562
Rheumatoid arthritis 4 | 1,156
Seizures 4 | 584
Small head 4 | 366
Squamous cell carcinoma 4 | 125
Thick, flared eyebrows 4 | 39
acute myeloid leukemia 4 | 760
acute quadriplegic myopathy 4 | 1,133
lung adenocarcinoma 4 | 2,627
primary pancreatic ductal adenocarcinoma 4 | 1,071
tuberculosis 4 | 1,963
ulcerative colitis 4 | 1,765
Acquired scoliosis 3 | 274
Adenocarcinoma of lung 3 | 140
Alcoholic Intoxication, Chronic 3 | 283
Asthma 3 | 370
Bilateral fifth finger clinodactyly 3 | 109
Bipolar Disorder 3 | 646
Bladder Neoplasm 3 | 106
Blepharoptosis 3 | 229
Brain Ischemia 3 | 107
Breast Neoplasms 3 | 423
Broad flat nasal bridge 3 | 232
Cerebrovascular disease 3 | 223
Cognitive delay 3 | 596
Congenital Epicanthus 3 | 175
Congenital deafness 3 | 180
Crohn's disease 3 | 311
Curvature of little finger 3 | 109
Curvature of spine 3 | 275
Deafness 3 | 193
Delayed bone age 3 | 132
Depressive disorder 3 | 401
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 634
Enophthalmos 3 | 74
Failure to gain weight 3 | 359
Familial primary pulmonary hypertension 3 | 11
Hearing Loss, Partial 3 | 180
Highly variable severity 3 | 149
Hypoplastic mandible condyle 3 | 273
Kidney Diseases 3 | 110
Liver Cirrhosis, Experimental 3 | 733
Low posterior hairline 3 | 52
Mammary Neoplasms 3 | 403
Mental and motor retardation 3 | 596
Nasal bridge wide 3 | 232
Pediatric failure to thrive 3 | 359
Penile hypospadias 3 | 102
Poor school performance 3 | 634
Psychotic Disorders 3 | 150
Sunken eyes 3 | 62
Urinary Bladder Neoplasms 3 | 108
Variable expressivity 3 | 149
Waldenstrons macroglobulinemia 3 | 742
colon cancer 3 | 1,428
diabetes mellitus 3 | 1,683
hearing impairment 3 | 194
interstitial cystitis 3 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,902
invasive ductal carcinoma 3 | 2,867
lung carcinoma 3 | 2,755
medulloblastoma 3 | 702
non-small cell lung cancer 3 | 2,799

Tissue

Endocrine System 32 | 18,159
Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Digestive Tract 31 | 17,369
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678

Target Family

Non-IDG 11 | 12,091
Epigenetic 10 | 242
Transcription Factor 7 | 1,400
Enzyme 3 | 4,145
Kinase 1 | 634

WikiPathways Pathway

Initiation of transcription an... 32 | 32
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.60752 391.4 125
Transcription elongation factor SPT5 SUPT5H Tbio Non-IDG -1.92374 80.5 135
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -3.00226 997.7 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520