Development Level

Tchem 18 | 1,598
Tbio 13 | 11,445
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499

Disease

Cancer 34 | 2,499
ovarian cancer 34 | 8,520
Carcinoma 31 | 11,493
osteosarcoma 30 | 7,950
glioblastoma 25 | 5,792
lung cancer 24 | 4,740
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 20 | 5,112
medulloblastoma, large-cell 20 | 6,241
ependymoma 18 | 4,679
Kidney cancer 16 | 2,613
Breast cancer 15 | 3,578
Rheumatoid arthritis 15 | 1,191
Multiple myeloma 14 | 1,332
diabetes mellitus 14 | 1,728
group 4 medulloblastoma 14 | 1,855
lung carcinoma 13 | 2,843
Astrocytoma, Pilocytic 12 | 3,081
Vascular disease 12 | 319
adult high grade glioma 12 | 3,801
invasive ductal carcinoma 12 | 2,951
Arthritis 11 | 290
Asthma 11 | 385
Obesity 11 | 678
Prostatic Neoplasms 11 | 495
Schizophrenia 11 | 1,160
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
juvenile dermatomyositis 11 | 1,187
non-small cell lung cancer 11 | 2,890
oligodendroglioma 11 | 2,850
pancreatic cancer 11 | 2,398
subependymal giant cell astrocytoma 11 | 2,287
Bipolar Disorder 10 | 666
Pick disease 10 | 1,894
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
ulcerative colitis 10 | 1,819
Hypertension 9 | 396
Short stature 9 | 531
astrocytoma 9 | 1,146
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,109
Acquired scoliosis 8 | 281
Byzanthine arch palate 8 | 194
Carcinoma, Squamous Cell 8 | 110
Curvature of spine 8 | 282
Depressive disorder 8 | 409
Heart disease 8 | 306
Hypertensive disease 8 | 292
Kidney disease 8 | 430
Lung Neoplasms 8 | 232
Multiple Sclerosis 8 | 540
Myocardial Ischemia 8 | 169
Neoplasm Metastasis 8 | 168
Orbital separation excessive 8 | 244
Squamous cell carcinoma 8 | 129
Stomach Neoplasms 8 | 300
cystic fibrosis 8 | 1,696
dermatomyositis 8 | 966
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
primitive neuroectodermal tumor 8 | 3,035
tuberculosis 8 | 2,010
Anemia 7 | 365
Arthritis, Rheumatoid 7 | 174
Blepharoptosis 7 | 231
Downward slant of palpebral fissure 7 | 158
Hypoplastic mandible condyle 7 | 275
Inflammation 7 | 120
Mandibular hypoplasia 7 | 275
Mental Depression 7 | 333
Micrognathism 7 | 275
Seizures 7 | 596
acute quadriplegic myopathy 7 | 1,158
astrocytic glioma 7 | 2,597
pancreatic carcinoma 7 | 562
Atherosclerosis 6 | 291
Autosomal recessive predisposition 6 | 1,442
Brain Ischemia 6 | 110
Carcinoma, Hepatocellular 6 | 228
Cardiomyopathies 6 | 110
Crohn's disease 6 | 321
Frontal bossing 6 | 157
Hyperglycemia 6 | 137
Immune system cancer 6 | 140
Inflammatory bowel disease 6 | 151
Intellectual disability 6 | 1,016
Liver Cirrhosis, Experimental 6 | 769
Liver carcinoma 6 | 240
Liver disease 6 | 237
Lymphoid leukemia 6 | 160
Major Depressive Disorder 6 | 301
Ovarian Neoplasms 6 | 102
Parkinson's disease 6 | 392
Pectus excavatum 6 | 100
Pneumonia 6 | 174
mucosa-associated lymphoid tissue lymphoma 6 | 484
ovarian neoplasm 6 | 99
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962

Tissue

Blood and immune system 43 | 16,909
Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 42 | 15,192
Male tissues 42 | 17,142
Respiratory system 42 | 16,393

Target Family

Kinase 16 | 634
Non-IDG 14 | 12,091
Enzyme 4 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

WikiPathways Pathway

IL-6 signaling pathway 43 | 43
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Interferon regulatory factor 1 IRF1 Tbio Transcription Factor -2.90315 827.7 366
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.36613 239.2 307
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075