Development Level

Tchem 25 | 1,598
Tbio 20 | 11,445
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal cornea morphology 2 | 31
preweaning lethality, incomple... 2 | 499
abnormal cecum morphology 1 | 7
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
microphthalmia 1 | 26
small thymus 1 | 16

Disease

Cancer 45 | 2,499
Carcinoma 41 | 11,493
osteosarcoma 36 | 7,950
ovarian cancer 36 | 8,520
lung cancer 29 | 4,740
psoriasis 27 | 6,694
glioblastoma 25 | 5,792
atypical teratoid / rhabdoid tumor 22 | 5,112
medulloblastoma, large-cell 22 | 6,241
Breast cancer 21 | 3,578
invasive ductal carcinoma 18 | 2,951
Rheumatoid arthritis 17 | 1,191
diabetes mellitus 17 | 1,728
Kidney cancer 16 | 2,613
malignant mesothelioma 16 | 3,232
Schizophrenia 15 | 1,160
adult high grade glioma 14 | 3,801
pancreatic cancer 14 | 2,398
Arthritis 13 | 290
Obesity 13 | 678
astrocytoma 13 | 1,146
tuberculosis 13 | 2,010
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
ependymoma 12 | 4,679
group 3 medulloblastoma 12 | 4,104
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
subependymal giant cell astrocytoma 12 | 2,287
Asthma 11 | 385
group 4 medulloblastoma 11 | 1,855
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pituitary cancer 11 | 1,972
Atopic dermatitis 10 | 952
Breast Neoplasms 10 | 445
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Mammary Neoplasms 10 | 425
Multiple myeloma 10 | 1,332
juvenile dermatomyositis 10 | 1,187
Carcinoma, Squamous Cell 9 | 110
Immune system cancer 9 | 140
Lung Neoplasms 9 | 232
Multiple Sclerosis 9 | 540
Squamous cell carcinoma 9 | 129
Vascular disease 9 | 319
non-small cell lung cancer 9 | 2,890
primitive neuroectodermal tumor 9 | 3,035
ulcerative colitis 9 | 1,819
Alzheimer's disease 8 | 658
Astrocytoma, Pilocytic 8 | 3,081
Brain Ischemia 8 | 110
Frontal bossing 8 | 157
Inflammatory bowel disease 8 | 151
Liver Cirrhosis, Experimental 8 | 769
Orbital separation excessive 8 | 244
Prostatic Neoplasms 8 | 495
Stomach Neoplasms 8 | 300
cutaneous lupus erythematosus 8 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
oligodendroglioma 8 | 2,850
Acquired scoliosis 7 | 281
Anemia 7 | 365
Autosomal recessive predisposition 7 | 1,442
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Cardiomyopathies 7 | 110
Cognitive delay 7 | 608
Curvature of spine 7 | 282
Downward slant of palpebral fissure 7 | 158
Failure to gain weight 7 | 365
Global developmental delay 7 | 608
Hyperglycemia 7 | 137
Hypoplastic mandible condyle 7 | 275
Lung disease 7 | 142
Lymphoid leukemia 7 | 160
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Pectus excavatum 7 | 100
Pediatric failure to thrive 7 | 365
Renal Cell Carcinoma 7 | 214
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 783
adrenocortical carcinoma 7 | 1,428
primary pancreatic ductal adenocarcinoma 7 | 1,109
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Depressive disorder 6 | 409
Dull intelligence 6 | 645
Epilepsy 6 | 792
Pick disease 6 | 1,894
Seizures 6 | 596
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
gastric carcinoma 6 | 807
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962

Tissue

Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Endocrine System 54 | 18,159
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Respiratory system 54 | 16,393
Skin and soft tissues 54 | 17,230
Urinary Tract 54 | 16,678
Cardiovascular System 53 | 15,192
Nervous System 52 | 16,725

Target Family

Non-IDG 17 | 12,091
Kinase 16 | 634
Transcription Factor 14 | 1,400
Enzyme 5 | 4,145
Epigenetic 1 | 242
GPCR 1 | 408

WikiPathways Pathway

IL-4 Signaling Pathway 54 | 54
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Histamine H1 receptor HRH1 Tclin GPCR -3.02485 1031.1 393
Suppressor of cytokine signaling 5 SOCS5 Tbio Non-IDG -2.04740 106.6 135
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565