Development Level

Tchem 18 | 1,598
Tbio 13 | 11,445
Tclin 11 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal gait 2 | 69
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
abnormal bone structure 1 | 187
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
male infertility 1 | 123
polycystic kidney 1 | 15
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Cancer 39 | 2,499
Carcinoma 33 | 11,493
ovarian cancer 30 | 8,520
osteosarcoma 26 | 7,950
medulloblastoma, large-cell 24 | 6,241
psoriasis 24 | 6,694
glioblastoma 23 | 5,792
lung cancer 21 | 4,740
Breast cancer 14 | 3,578
Rheumatoid arthritis 14 | 1,191
atypical teratoid / rhabdoid tumor 14 | 5,112
Schizophrenia 13 | 1,160
Vascular disease 13 | 319
malignant mesothelioma 13 | 3,232
Multiple myeloma 12 | 1,332
diabetes mellitus 12 | 1,728
ependymoma 12 | 4,679
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
Kidney cancer 11 | 2,613
Multiple Sclerosis 11 | 540
group 3 medulloblastoma 11 | 4,104
group 4 medulloblastoma 11 | 1,855
oligodendroglioma 11 | 2,850
Arthritis 10 | 290
Asthma 10 | 385
Breast Neoplasms 10 | 445
Lung Neoplasms 10 | 232
Mammary Neoplasms 10 | 425
Orbital separation excessive 10 | 244
Short stature 10 | 531
astrocytoma 10 | 1,146
interstitial cystitis 10 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
pituitary cancer 10 | 1,972
Alzheimer's disease 9 | 658
Astrocytoma, Pilocytic 9 | 3,081
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Stomach Neoplasms 9 | 300
adult high grade glioma 9 | 3,801
breast carcinoma 9 | 1,638
juvenile dermatomyositis 9 | 1,187
lung adenocarcinoma 9 | 2,716
pancreatic cancer 9 | 2,398
tuberculosis 9 | 2,010
Bipolar Disorder 8 | 666
Blepharoptosis 8 | 231
Byzanthine arch palate 8 | 194
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Downward slant of palpebral fissure 8 | 158
Heart disease 8 | 306
Hypertrophic Cardiomyopathy 8 | 117
Melanoma 8 | 711
Obesity 8 | 678
Pick disease 8 | 1,894
astrocytic glioma 8 | 2,597
ductal carcinoma in situ 8 | 1,745
non-small cell lung cancer 8 | 2,890
primary Sjogren syndrome 8 | 735
subependymal giant cell astrocytoma 8 | 2,287
Acquired scoliosis 7 | 281
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Congenital Epicanthus 7 | 177
Cryptorchidism 7 | 296
Curvature of spine 7 | 282
Disease Models, Animal 7 | 155
Dull intelligence 7 | 645
Hypersensitivity reaction type II disease 7 | 253
Hypoplastic mandible condyle 7 | 275
Immune system cancer 7 | 140
Intellectual disability 7 | 1,016
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Mandibular hypoplasia 7 | 275
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Micrognathism 7 | 275
Muscle hypotonia 7 | 571
Neck webbing 7 | 35
Neoplasm Metastasis 7 | 168
Pectus excavatum 7 | 100
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
Short neck 7 | 140
Squamous cell carcinoma 7 | 129
cutaneous lupus erythematosus 7 | 1,057
dermatomyositis 7 | 966
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
primitive neuroectodermal tumor 7 | 3,035
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Depressive disorder 6 | 409
Hepatomegaly 6 | 285
Strabismus 6 | 270
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Skin and soft tissues 42 | 17,230
Cardiovascular System 41 | 15,192
Endocrine System 41 | 18,159
Nervous System 41 | 16,725
Respiratory system 41 | 16,393
Urinary Tract 41 | 16,678

Target Family

Non-IDG 16 | 12,091
Kinase 15 | 634
Transcription Factor 8 | 1,400
Enzyme 3 | 4,145

WikiPathways Pathway

IL-2 Signaling Pathway 42 | 42
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248