Development Level

Tchem 33 | 1,890
Tbio 17 | 10,625
Tclin 5 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 3 | 633
decreased body weight 2 | 174
decreased circulating creatini... 2 | 31
decreased circulating sodium l... 2 | 18
increased circulating alkaline... 2 | 119
increased circulating iron lev... 2 | 25
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal motor learning 1 | 4
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
absent vibrissae 1 | 14
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased bone mineral content 1 | 157
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
improved glucose tolerance 1 | 56
increased NK cell number 1 | 19
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased erythrocyte cell num... 1 | 26
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
short tibia 1 | 82
tremors 1 | 34

Disease

Cancer 35 | 2,346
ovarian cancer 32 | 8,484
glioblastoma 30 | 5,572
psoriasis 29 | 6,685
osteosarcoma 28 | 7,933
lung cancer 24 | 4,466
medulloblastoma, large-cell 23 | 6,234
atypical teratoid / rhabdoid tumor 20 | 4,369
oligodendroglioma 15 | 2,849
pilocytic astrocytoma 15 | 3,086
Arthritis 14 | 248
Rheumatoid Arthritis 14 | 1,160
malignant mesothelioma 14 | 3,162
tuberculosis 14 | 1,557
non-small cell lung cancer 13 | 2,798
primitive neuroectodermal tumor 13 | 3,031
Vascular disease 12 | 281
diabetes mellitus 12 | 1,663
pancreatic cancer 12 | 2,300
pituitary cancer 12 | 1,972
subependymal giant cell astrocytoma 12 | 2,287
Breast cancer 11 | 3,094
Pick disease 11 | 1,893
group 4 medulloblastoma 11 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
lung carcinoma 11 | 2,844
Asthma 10 | 349
Brain Ischemia 10 | 87
dermatomyositis 10 | 933
ependymoma 10 | 2,514
juvenile dermatomyositis 10 | 1,189
pediatric high grade glioma 10 | 2,712
ulcerative colitis 10 | 2,087
Alzheimer's disease 9 | 644
Lung disease 9 | 132
Reperfusion Injury 9 | 84
adult high grade glioma 9 | 2,148
astrocytoma 9 | 1,493
cystic fibrosis 9 | 1,665
lung adenocarcinoma 9 | 2,713
medulloblastoma 9 | 1,524
Carcinoma 8 | 2,147
Inflammatory bowel disease 8 | 142
Lung Neoplasms 8 | 171
acute myeloid leukemia 8 | 780
astrocytic glioma 8 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
spina bifida 8 | 1,064
Kidney disease 7 | 396
Mammary Neoplasms 7 | 410
Obesity 7 | 616
breast carcinoma 7 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
invasive ductal carcinoma 7 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
primary pancreatic ductal adenocarcinoma 7 | 1,271
Cardiomyopathies 6 | 90
Eye disease 6 | 55
Heart disease 6 | 279
Heat Stroke 6 | 12
Multiple myeloma 6 | 1,327
Parkinson's disease 6 | 364
Schizophrenia 6 | 501
Toxic encephalopathy 6 | 131
acute quadriplegic myopathy 6 | 1,157
Brain disease 5 | 83
Colonic Neoplasms 5 | 126
Endometriosis 5 | 535
Gaucher disease type 1 5 | 171
Hyperalgesia 5 | 71
Hyperglycemia 5 | 120
Inflammation 5 | 109
Multiple Sclerosis 5 | 498
Myocardial Ischemia 5 | 169
Neoplastic Cell Transformation 5 | 81
Osteoporosis 5 | 257
Pneumonia 5 | 133
Prostatic Neoplasms 5 | 471
Stomach Neoplasms 5 | 282
adrenocortical carcinoma 5 | 1,427
colon cancer 5 | 1,475
interstitial cystitis 5 | 2,299
pancreatic carcinoma 5 | 567
Coronary artery disease 4 | 240
Dermatologic disorders 4 | 65
Fatty liver disease 4 | 84
Hypersensitivity 4 | 63
Hypersensitivity reaction type II disease 4 | 235
Influenza 4 | 142
Liver disease 4 | 219
Meningitis 4 | 46
Metabolic syndrome X 4 | 155
Neoplasm Invasiveness 4 | 127
Waldenstrons macroglobulinemia 4 | 765
cutaneous lupus erythematosus 4 | 1,056
ductal carcinoma in situ 4 | 1,745
hepatocellular carcinoma 4 | 532
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686

Tissue

Blood and immune system 55 | 17,995
Cardiovascular System 55 | 17,958
Digestive Tract 55 | 18,473
Endocrine System 55 | 18,512
Female tissues 55 | 18,647
Liver and Pancreas 55 | 18,136
Male tissues 55 | 17,969
Nervous System 55 | 18,561
Respiratory system 55 | 17,484
Urinary Tract 55 | 18,444
Skin and soft tissues 54 | 18,115

Target Family

Kinase 28 | 634
Non-IDG 15 | 11,971
Enzyme 7 | 4,146
Transcription Factor 5 | 1,400

WikiPathways Pathway

IL-1 signaling pathway 55 | 55
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Interleukin-1 receptor type 1 IL1R1 Tclin Non-IDG -2.63413 362.9 482
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Toll-interacting protein TOLLIP Tbio Non-IDG -1.78649 72.7 353
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.78634 57.0 688
Ubiquitin-conjugating enzyme E2 N UBE2N Tchem Non-IDG -2.02460 99.0 237