Development Level

Tchem 30 | 1,388
Tbio 20 | 11,651
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal motor learning 1 | 3
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
tremors 1 | 39

Disease

Carcinoma 40 | 11,493
Cancer 35 | 2,499
glioblastoma 32 | 5,792
ovarian cancer 32 | 8,520
psoriasis 29 | 6,694
osteosarcoma 28 | 7,950
lung cancer 26 | 4,740
medulloblastoma, large-cell 23 | 6,241
atypical teratoid / rhabdoid tumor 22 | 5,112
ependymoma 17 | 4,679
adult high grade glioma 16 | 3,801
Arthritis 15 | 290
oligodendroglioma 15 | 2,850
tuberculosis 15 | 2,010
Astrocytoma, Pilocytic 14 | 3,081
Rheumatoid arthritis 14 | 1,191
malignant mesothelioma 14 | 3,232
Breast cancer 13 | 3,578
Schizophrenia 13 | 1,160
diabetes mellitus 13 | 1,728
non-small cell lung cancer 13 | 2,890
pancreatic cancer 13 | 2,398
primitive neuroectodermal tumor 13 | 3,035
Vascular disease 12 | 319
pituitary cancer 12 | 1,972
subependymal giant cell astrocytoma 12 | 2,287
Asthma 11 | 385
Pick disease 11 | 1,894
group 3 medulloblastoma 11 | 4,104
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung carcinoma 11 | 2,843
Brain Ischemia 10 | 110
Inflammatory bowel disease 10 | 151
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
Cholestasis, Extrahepatic 9 | 25
Kidney cancer 9 | 2,613
Lung disease 9 | 142
Reperfusion Injury 9 | 86
astrocytic glioma 9 | 2,597
cystic fibrosis 9 | 1,696
lung adenocarcinoma 9 | 2,716
ulcerative colitis 9 | 1,819
Alzheimer's disease 8 | 658
Hyperalgesia 8 | 83
Hyperglycemia 8 | 137
Lung Neoplasms 8 | 232
acute myeloid leukemia 8 | 783
astrocytoma 8 | 1,146
breast carcinoma 8 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
spina bifida 8 | 1,074
Breast Neoplasms 7 | 445
Disease Models, Animal 7 | 155
Kidney disease 7 | 430
Mammary Neoplasms 7 | 425
Obesity 7 | 678
Parkinson's disease 7 | 392
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
Acquired scoliosis 6 | 281
Bipolar Disorder 6 | 666
Cardiomyopathies 6 | 110
Curvature of spine 6 | 282
Depressive disorder 6 | 409
Eye disease 6 | 62
Frontal bossing 6 | 157
Heart disease 6 | 306
Heat Stroke 6 | 13
Hypersensitivity reaction type II disease 6 | 253
Hypertension 6 | 396
Immunologic Deficiency Syndromes 6 | 113
Multiple myeloma 6 | 1,332
Neoplasm Invasiveness 6 | 161
Orbital separation excessive 6 | 244
Osteoporosis 6 | 363
Pneumonia 6 | 174
Short stature 6 | 531
Stomach Neoplasms 6 | 300
Toxic encephalopathy 6 | 141
acute quadriplegic myopathy 6 | 1,158
Alcoholic Intoxication, Chronic 5 | 289
Blepharoptosis 5 | 231
Byzanthine arch palate 5 | 194
Colonic Neoplasms 5 | 142
Endometriosis 5 | 540
Inflammation 5 | 120
Mental Depression 5 | 333
Multiple Sclerosis 5 | 540
Myocardial Ischemia 5 | 169
Myopia 5 | 176
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
interstitial cystitis 5 | 2,312
pancreatic carcinoma 5 | 562

Tissue

Blood and immune system 55 | 16,909
Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Cardiovascular System 54 | 15,192

Target Family

Kinase 28 | 634
Non-IDG 15 | 12,091
Enzyme 7 | 4,145
Transcription Factor 5 | 1,400

WikiPathways Pathway

IL-1 signaling pathway 55 | 55
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Interleukin-1 receptor-associated kinase 3 IRAK3 Tchem Kinase -1.86631 84.0 427
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.73612 54.7 183
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765