Development Level

Tchem 33 | 1,885
Tbio 17 | 11,178
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal motor learning 1 | 3
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
tremors 1 | 39

Disease

Carcinoma 39 | 11,192
Cancer 34 | 2,388
glioblastoma 32 | 5,635
ovarian cancer 31 | 8,297
psoriasis 29 | 6,514
osteosarcoma 27 | 7,766
lung cancer 26 | 4,607
medulloblastoma, large-cell 22 | 6,086
atypical teratoid / rhabdoid tumor 21 | 4,971
ependymoma 17 | 4,559
adult high grade glioma 16 | 3,701
Arthritis 15 | 276
oligodendroglioma 15 | 2,768
tuberculosis 15 | 1,963
Astrocytoma, Pilocytic 14 | 3,006
Rheumatoid arthritis 14 | 1,156
malignant mesothelioma 14 | 3,135
Breast cancer 13 | 3,469
Schizophrenia 13 | 1,136
diabetes mellitus 13 | 1,683
non-small cell lung cancer 13 | 2,799
pancreatic cancer 13 | 2,322
primitive neuroectodermal tumor 13 | 2,957
Vascular disease 12 | 294
pituitary cancer 12 | 1,915
subependymal giant cell astrocytoma 12 | 2,230
Asthma 11 | 370
Pick disease 11 | 1,856
group 3 medulloblastoma 11 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,204
lung carcinoma 11 | 2,755
Brain Ischemia 10 | 107
Inflammatory bowel disease 10 | 148
dermatomyositis 10 | 941
group 4 medulloblastoma 10 | 1,806
juvenile dermatomyositis 10 | 1,147
Cholestasis, Extrahepatic 9 | 20
Kidney cancer 9 | 2,548
Lung disease 9 | 135
Reperfusion Injury 9 | 84
astrocytic glioma 9 | 2,530
cystic fibrosis 9 | 1,629
lung adenocarcinoma 9 | 2,627
ulcerative colitis 9 | 1,765
Alzheimer's disease 8 | 640
Hyperalgesia 8 | 80
Hyperglycemia 8 | 134
Lung Neoplasms 8 | 217
acute myeloid leukemia 8 | 760
astrocytoma 8 | 1,113
breast carcinoma 8 | 1,589
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,902
spina bifida 8 | 1,053
Breast Neoplasms 7 | 423
Disease Models, Animal 7 | 148
Kidney disease 7 | 411
Mammary Neoplasms 7 | 403
Obesity 7 | 655
Parkinson's disease 7 | 378
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,872
invasive ductal carcinoma 7 | 2,867
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
primary pancreatic ductal adenocarcinoma 7 | 1,071
Acquired scoliosis 6 | 274
Bipolar Disorder 6 | 646
Cardiomyopathies 6 | 109
Curvature of spine 6 | 275
Depressive disorder 6 | 401
Eye disease 6 | 59
Frontal bossing 6 | 154
Heart disease 6 | 288
Heat Stroke 6 | 12
Hypersensitivity reaction type II disease 6 | 245
Hypertension 6 | 372
Immunologic Deficiency Syndromes 6 | 110
Multiple myeloma 6 | 1,296
Neoplasm Invasiveness 6 | 151
Orbital separation excessive 6 | 240
Osteoporosis 6 | 348
Pneumonia 6 | 169
Short stature 6 | 514
Stomach Neoplasms 6 | 287
Toxic encephalopathy 6 | 139
acute quadriplegic myopathy 6 | 1,133
Alcoholic Intoxication, Chronic 5 | 283
Blepharoptosis 5 | 229
Byzanthine arch palate 5 | 194
Colonic Neoplasms 5 | 133
Endometriosis 5 | 521
Inflammation 5 | 116
Mental Depression 5 | 325
Multiple Sclerosis 5 | 527
Myocardial Ischemia 5 | 162
Myopia 5 | 175
Prostatic Neoplasms 5 | 472
Seizures 5 | 584
adrenocortical carcinoma 5 | 1,385
colon cancer 5 | 1,428
interstitial cystitis 5 | 2,237
pancreatic carcinoma 5 | 555

Tissue

Blood and immune system 55 | 16,909
Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Cardiovascular System 54 | 15,192

Target Family

Kinase 28 | 634
Non-IDG 15 | 12,091
Enzyme 7 | 4,145
Transcription Factor 5 | 1,400

WikiPathways Pathway

IL-1 signaling pathway 55 | 55
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tbio Kinase -2.12399 119.4 334
Interleukin-1 receptor accessory protein IL1RAP Tclin Non-IDG -1.81693 53.3 264
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Interleukin-1 beta IL1B Tclin Non-IDG -4.40738 24522.4 1588