Development Level

Tbio 13 | 11,651
Tchem 3 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased threshold for audito... 1 | 26
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112

Disease

Carcinoma 13 | 11,493
Cancer 12 | 2,499
osteosarcoma 12 | 7,950
medulloblastoma, large-cell 10 | 6,241
ovarian cancer 10 | 8,520
glioblastoma 9 | 5,792
psoriasis 9 | 6,694
lung cancer 8 | 4,740
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
malignant mesothelioma 7 | 3,232
adrenocortical carcinoma 6 | 1,428
Astrocytoma, Pilocytic 5 | 3,081
astrocytoma 5 | 1,146
group 4 medulloblastoma 5 | 1,855
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
Rheumatoid arthritis 4 | 1,191
adult high grade glioma 4 | 3,801
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Breast Neoplasms 3 | 445
Breast cancer 3 | 3,578
Carcinoma, Hepatocellular 3 | 228
Chronic Lymphocytic Leukemia 3 | 262
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Mammary Neoplasms 3 | 425
Mammary Neoplasms, Experimental 3 | 154
Orbital separation excessive 3 | 244
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
nasopharyngeal carcinoma 3 | 1,058
primary Sjogren syndrome 3 | 735
primitive neuroectodermal tumor 3 | 3,035
Abnormally small eyeball 2 | 97
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Bladder Neoplasm 2 | 112
Cleft Palate 2 | 271
Congenital hypoplasia of lung 2 | 48
Decreased size of eyeball 2 | 97
Diabetes Mellitus, Experimental 2 | 108
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Dull intelligence 2 | 645
Endometriosis 2 | 540
Fetal Growth Retardation 2 | 189
Hypoplastic mandible condyle 2 | 275
Immune system cancer 2 | 140
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
Kidney disease 2 | 430
Low intelligence 2 | 645
Low set ears 2 | 181
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Mammary Neoplasms, Animal 2 | 136
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Micrognathism 2 | 275
Microphthalmos 2 | 100
Muscle hypotonia 2 | 571
Myocardial Ischemia 2 | 169
Obesity 2 | 678
Ovarian Neoplasms 2 | 102
Pick disease 2 | 1,894
Poor school performance 2 | 645
Precursor Cell Lymphoblastic Leukemia Lymphoma 2 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 | 49
Retinoblastoma 2 | 19
Short stature 2 | 531
Uranostaphyloschisis 2 | 167
Urinary Bladder Neoplasms 2 | 114
Urinary bladder cancer 2 | 36
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
gastric cancer 2 | 459
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
ovarian neoplasm 2 | 99
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819

Tissue

Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Digestive Tract 15 | 17,369
Nervous System 15 | 16,725
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Liver and Pancreas 14 | 16,750
Respiratory system 14 | 16,393

Target Family

Transcription Factor 11 | 1,400
Non-IDG 4 | 12,091
Kinase 1 | 634

WikiPathways Pathway

ID signaling pathway 16 | 16
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.44266 2522.8 1114
G1/S-specific cyclin-E1 CCNE1 Tchem Non-IDG -2.47823 262.4 894
Sterol regulatory element-binding protein 1 SREBF1 Tbio Transcription Factor -3.12075 1267.4 429
Retinoblastoma-like protein 2 RBL2 Tbio Non-IDG -2.71244 526.8 359
DNA-binding protein inhibitor ID-2 ID2 Tbio Transcription Factor -2.47954 307.2 302
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
DNA-binding protein inhibitor ID-1 ID1 Tbio Transcription Factor -2.62261 440.3 311
DNA-binding protein inhibitor ID-3 ID3 Tbio Transcription Factor -2.36130 229.3 402