Development Level

Tbio 2 | 11,651

IMPC Phenotype

abnormal retina morphology 1 | 71
absent spleen 1 | 3
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
preweaning lethality, complete... 1 | 979

Disease

Breast cancer 2 | 3,578
Cancer 2 | 2,499
Carcinoma 2 | 11,493
Kidney cancer 2 | 2,613
astrocytic glioma 2 | 2,597
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
ovarian neoplasm 2 | 99
primitive neuroectodermal tumor 2 | 3,035
psoriasis 2 | 6,694
ulcerative colitis 2 | 1,819
Abnormality of metabolism/homeostasis 1 | 134
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Astrocytoma, Pilocytic 1 | 3,081
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Breast Neoplasms 1 | 445
CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 1 | 1
CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) 1 | 1
Cell Transformation, Neoplastic 1 | 97
Corneal Dystrophy, Posterior Polymorphous, 3 1 | 1
Corneal dystrophy 1 | 24
Corneal guttata 1 | 2
Cystic nephroma 1 | 5
Disease Progression 1 | 136
Endometrial Neoplasms 1 | 55
Endometrial cancer 1 | 311
Endometriosis 1 | 540
Euthyroid Goiter 1 | 3
Fragile X syndrome 1 | 34
Fuchs Endothelial Dystrophy 1 | 5
Fuchs' endothelial dystrophy 1 | 24
Gaucher disease type 1 1 | 180
Gaucher disease type 3 1 | 67
Goiter 1 | 38
Granulosa Cell Cancer 1 | 1
Granulosa cell tumor 1 | 6
Gynandroblastoma 1 | 1
Keratoconus 1 | 113
Liver cancer 1 | 604
Lymphoma, T-Cell, Cutaneous 1 | 22
Malignant Granulosa Cell Tumor 1 | 1
Mammary Neoplasms 1 | 425
Multinodular goiter 1 | 3
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Neoplastic Cell Transformation 1 | 89
Oligospermia 1 | 36
Oral Submucous Fibrosis 1 | 20
Ovarian Neoplasms 1 | 102
Papillary thyroid carcinoma 1 | 43
Pick disease 1 | 1,894
Pleuropulmonary blastoma 1 | 1
Polymorphous corneal dystrophy 1 | 4
Polyp of large intestine 1 | 8
Posterior polymorphous corneal dystrophy 1 | 19
Renal Cell Carcinoma 1 | 214
Rhabdomyosarcoma 1 | 39
Rhabdomyosarcoma, Embryonal 1 | 5
Schizophrenia 1 | 1,160
Seminoma 1 | 15
Sertoli-Leydig cell tumor 1 | 5
Sezary Syndrome 1 | 27
Skin cancer 1 | 469
Thyroid cancer, papillary 1 | 14
Waldenstrons macroglobulinemia 1 | 765
Wilms Tumor 1 | 28
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
aldosterone-producing adenoma 1 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
dermatomyositis 1 | 966
gastric carcinoma 1 | 807
hepatocellular carcinoma 1 | 547
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic cancer 1 | 2,398
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
primary Sjogren syndrome 1 | 735
primary pancreatic ductal adenocarcinoma 1 | 1,109
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Enzyme 1 | 4,145
Transcription Factor 1 | 1,400

WikiPathways Pathway

Hypoxia-mediated EMT and Stemn... 2 | 2
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger E-box-binding homeobox 1 ZEB1 Tbio Transcription Factor -2.88752 659.2 460
Endoribonuclease Dicer DICER1 Tbio Enzyme -3.34177 2054.3 327