Development Level

Tbio 7 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal testis morphology 1 | 43
decreased eosinophil cell numb... 1 | 24
edema 1 | 59
enlarged lymph nodes 1 | 37

Disease

Cancer 6 | 2,499
Cleft Palate 6 | 271
Breast cancer 5 | 3,578
Carcinoma 5 | 11,493
Cleft Lip 5 | 141
Short stature 4 | 531
Uranostaphyloschisis 4 | 167
interstitial cystitis 4 | 2,312
non-small cell lung cancer 4 | 2,890
ovarian cancer 4 | 8,520
Cleft uvula 3 | 27
Craniofacial Abnormalities 3 | 151
Cryptorchidism 3 | 296
Decreased size of teeth 3 | 62
Decreased width of tooth 3 | 59
Hypoplastic mandible condyle 3 | 275
Mandibular hypoplasia 3 | 275
Microdontia (disorder) 3 | 59
Micrognathism 3 | 275
Non-midline cleft lip 3 | 6
atypical teratoid / rhabdoid tumor 3 | 5,112
ductal carcinoma in situ 3 | 1,745
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
pancreatic cancer 3 | 2,398
Accessory nipple 2 | 11
Acquired scoliosis 2 | 281
Agenesis of teeth 2 | 21
Ankyloblepharon 2 | 4
Ankyloblepharon filiforme adnatum 2 | 4
Atrophic condition of skin 2 | 25
Blepharoptosis 2 | 231
Blue sclera 2 | 32
Branchiooculofacial syndrome 2 | 13
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Cleft lip and alveolus 2 | 4
Cleft palate with cleft lip 2 | 23
Concave bridge of nose 2 | 195
Conductive hearing loss 2 | 123
Congenital absence of kidney 2 | 31
Congenital small ears 2 | 48
Coronary artery disease 2 | 268
Curvature of spine 2 | 282
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Dental abnormalities 2 | 60
Dental caries 2 | 164
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Fingernail dysplasia 2 | 6
Hernia, Inguinal 2 | 89
Hypodontia 2 | 81
Hypoplasia of the maxilla 2 | 66
Hypotrophic malar bone 2 | 129
Hypotrophic maxilla 2 | 66
Kidney cancer 2 | 2,613
Lacrimal Duct Obstruction 2 | 16
Leiomyoma 2 | 32
Limb Deformities, Congenital 2 | 16
Lower lip pits 2 | 2
Malar flattening 2 | 129
Maxillary retrognathia 2 | 66
Melanoma 2 | 711
Missing more than six teeth 2 | 22
Nasal bridge wide 2 | 236
Obstruction of nasolacrimal duct 2 | 9
Oligodontia 2 | 24
Orbital separation excessive 2 | 244
Patent ductus arteriosus 2 | 90
Penile hypospadias 2 | 106
Reduced number of teeth 2 | 21
Retrusion of upper jaw bones 2 | 66
Rheumatoid arthritis 2 | 1,191
Skin Abnormalities 2 | 37
Skin cancer 2 | 469
Small labia majora 2 | 16
Syndactyly of fingers 2 | 48
Syndactyly of the toes 2 | 45
Tooth Abnormalities 2 | 69
Tooth agenesis 2 | 44
Wide spaced nipples 2 | 46
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
psoriasis 2 | 6,694
spina bifida 2 | 1,074
Adhesions of uterus 1 | 4
Congenital neurologic anomalies 1 | 20
Dystrophic toenail changes 1 | 12
Lacrimation abnormality 1 | 4
Proximally placed thumbs 1 | 17

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Urinary Tract 7 | 16,678
Cardiovascular System 6 | 15,192
Male tissues 6 | 17,142
Skin and soft tissues 6 | 17,230

Target Family

Transcription Factor 3 | 1,400
Enzyme 2 | 4,145
Non-IDG 2 | 12,091

WikiPathways Pathway

Hypothetical Craniofacial Deve... 7 | 7
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon regulatory factor 6 IRF6 Tbio Transcription Factor -3.31408 2011.9 238
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Rho GTPase-activating protein 29 ARHGAP29 Tbio Enzyme -1.01817 12.0 72
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Tumor protein 63 TP63 Tbio Transcription Factor -3.07398 1154.1 448
Transcription factor AP-2-alpha TFAP2A Tbio Transcription Factor -2.48414 289.3 396