Development Level

Tbio 15 | 11,445
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

decreased total body fat amoun... 2 | 207
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal incisor morphology 1 | 4
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 23 | 11,493
ovarian cancer 22 | 8,520
Cancer 19 | 2,499
glioblastoma 19 | 5,792
osteosarcoma 18 | 7,950
Breast cancer 16 | 3,578
psoriasis 15 | 6,694
Astrocytoma, Pilocytic 14 | 3,081
atypical teratoid / rhabdoid tumor 13 | 5,112
ependymoma 13 | 4,679
pancreatic cancer 13 | 2,398
Kidney cancer 11 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
lung cancer 11 | 4,740
lung carcinoma 11 | 2,843
adult high grade glioma 10 | 3,801
diabetes mellitus 10 | 1,728
group 3 medulloblastoma 10 | 4,104
invasive ductal carcinoma 10 | 2,951
primary pancreatic ductal adenocarcinoma 10 | 1,109
Heart disease 9 | 306
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
juvenile dermatomyositis 9 | 1,187
malignant mesothelioma 9 | 3,232
subependymal giant cell astrocytoma 9 | 2,287
Hypertensive disease 8 | 292
Kidney disease 8 | 430
cystic fibrosis 8 | 1,696
lung adenocarcinoma 8 | 2,716
medulloblastoma, large-cell 8 | 6,241
non-small cell lung cancer 8 | 2,890
Byzanthine arch palate 7 | 194
Liver Cirrhosis, Experimental 7 | 769
Orbital separation excessive 7 | 244
Patent ductus arteriosus 7 | 90
Vascular disease 7 | 319
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
tuberculosis 7 | 2,010
Acquired flat foot 6 | 72
Acquired scoliosis 6 | 281
Aortic Valve Insufficiency 6 | 40
Arachnodactyly 6 | 49
Atopic dermatitis 6 | 952
Brachydactyly 6 | 156
Coronary artery disease 6 | 268
Curvature of spine 6 | 282
Flatfoot 6 | 73
Hypertension 6 | 396
Hypotrophic malar bone 6 | 129
Malar flattening 6 | 129
Obesity 6 | 678
Short stature 6 | 531
Ureteral obstruction 6 | 33
acute quadriplegic myopathy 6 | 1,158
ductal carcinoma in situ 6 | 1,745
gastric carcinoma 6 | 807
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Aortic aneurysm 5 | 38
Arthritis 5 | 290
Cardiomegaly 5 | 116
Craniofacial Abnormalities 5 | 151
Heart failure 5 | 162
Hyperglycemia 5 | 137
Hypoplastic mandible condyle 5 | 275
Increase in blood pressure 5 | 119
Liver Cirrhosis 5 | 181
Liver disease 5 | 237
Loeys-Dietz syndrome 5 | 23
Lung Neoplasms 5 | 232
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Schizophrenia 5 | 1,160
Stomach Neoplasms 5 | 300
cutaneous lupus erythematosus 5 | 1,057
group 4 medulloblastoma 5 | 1,855
ulcerative colitis 5 | 1,819
Colorectal Neoplasms 4 | 243
Decreased joint mobility 4 | 53
Disease Models, Animal 4 | 155
Duchenne muscular dystrophy 4 | 601
Epilepsy 4 | 792
Flexion contracture of proximal interphalangeal joint 4 | 75
Glaucoma 4 | 239
Lung disease 4 | 142
Myopia 4 | 176
Neoplasm Metastasis 4 | 168
Osteoarthritis 4 | 184
Osteoporosis 4 | 363
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
Weill-Marchesani syndrome 4 | 14
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
limb girdle muscular dystrophy 2A 4 | 213
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
pediatric high grade glioma 4 | 1,064

Tissue

Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Liver and Pancreas 24 | 16,750

Target Family

Non-IDG 13 | 12,091
Kinase 6 | 634
Transcription Factor 4 | 1,400
GPCR 1 | 408
Nuclear Receptor 1 | 48

WikiPathways Pathway

Hypothesized Pathways in Patho... 25 | 25
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Latent-transforming growth factor beta-binding protein 2 LTBP2 Tbio Non-IDG -1.22721 18.2 100
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Fibrillin-3 FBN3 Tbio Non-IDG -1.23024 15.7 16
Fibrillin-1 FBN1 Tbio Non-IDG -3.08679 1236.3 325
Fibrillin-2 FBN2 Tbio Non-IDG -2.46578 287.6 123
Periostin POSTN Tbio Non-IDG -2.84323 747.5 396
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605