Development Level

Tbio 35 | 11,445
Tchem 21 | 1,598
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal behavior 2 | 298
abnormal neural tube closure 2 | 46
embryonic growth retardation 2 | 106
female infertility 2 | 60
hyperactivity 2 | 148
impaired righting response 2 | 26
male infertility 2 | 123
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal midbrain morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
absent seminal vesicle 1 | 4
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased circulating LDL chol... 1 | 13
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small uterus 1 | 3

Disease

Carcinoma 52 | 11,493
ovarian cancer 50 | 8,520
Cancer 46 | 2,499
glioblastoma 39 | 5,792
medulloblastoma, large-cell 38 | 6,241
lung cancer 37 | 4,740
psoriasis 36 | 6,694
atypical teratoid / rhabdoid tumor 35 | 5,112
osteosarcoma 35 | 7,950
ependymoma 29 | 4,679
Breast cancer 24 | 3,578
Kidney cancer 24 | 2,613
oligodendroglioma 22 | 2,850
group 3 medulloblastoma 21 | 4,104
adult high grade glioma 20 | 3,801
pancreatic cancer 18 | 2,398
primitive neuroectodermal tumor 18 | 3,035
Obesity 17 | 678
astrocytic glioma 17 | 2,597
group 4 medulloblastoma 17 | 1,855
Astrocytoma, Pilocytic 16 | 3,081
Breast Neoplasms 16 | 445
Carcinoma, Hepatocellular 16 | 228
Intellectual disability 16 | 1,016
Liver carcinoma 16 | 240
Mammary Neoplasms 16 | 425
Lung Neoplasms 15 | 232
Schizophrenia 15 | 1,160
Short stature 15 | 531
diabetes mellitus 15 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
lung adenocarcinoma 15 | 2,716
pituitary cancer 15 | 1,972
Rheumatoid arthritis 14 | 1,191
Vascular disease 14 | 319
colon cancer 14 | 1,478
non-small cell lung cancer 14 | 2,890
tuberculosis 14 | 2,010
Adenoma 13 | 167
Dull intelligence 13 | 645
Epilepsy 13 | 792
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Pick disease 13 | 1,894
Poor school performance 13 | 645
Stomach Neoplasms 13 | 300
ulcerative colitis 13 | 1,819
Alzheimer's disease 12 | 658
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Kidney disease 12 | 430
Mental and motor retardation 12 | 608
adrenocortical carcinoma 12 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
invasive ductal carcinoma 12 | 2,951
Arthritis 11 | 290
Liver cancer 11 | 604
Multiple myeloma 11 | 1,332
Muscle hypotonia 11 | 571
Prostatic Neoplasms 11 | 495
astrocytoma 11 | 1,146
breast carcinoma 11 | 1,638
lung carcinoma 11 | 2,843
malignant mesothelioma 11 | 3,232
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Melanoma 10 | 711
Orbital separation excessive 10 | 244
Ovarian Neoplasms 10 | 102
Seizures 10 | 596
Substance Withdrawal Syndrome 10 | 55
interstitial cystitis 10 | 2,312
juvenile dermatomyositis 10 | 1,187
Acquired scoliosis 9 | 281
Blepharoptosis 9 | 231
Byzanthine arch palate 9 | 194
Curvature of spine 9 | 282
Depressive disorder 9 | 409
Disease Progression 9 | 136
Hypothyroidism 9 | 122
Isolated cases 9 | 72
Parkinson's disease 9 | 392
Thyroid cancer 9 | 36
ovarian neoplasm 9 | 99
subependymal giant cell astrocytoma 9 | 2,287
Asthma 8 | 385
Autosomal recessive predisposition 8 | 1,442
Brain Ischemia 8 | 110
Failure to gain weight 8 | 365
Heart disease 8 | 306
Hypoplastic mandible condyle 8 | 275
Liver neoplasms 8 | 130
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Pediatric failure to thrive 8 | 365
acute myeloid leukemia 8 | 783
ductal carcinoma in situ 8 | 1,745

Tissue

Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Endocrine System 65 | 18,159
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Nervous System 65 | 16,725
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Cardiovascular System 64 | 15,192
Male tissues 64 | 17,142
Respiratory system 64 | 16,393

Target Family

Non-IDG 23 | 12,091
Kinase 21 | 634
Enzyme 12 | 4,145
Transcription Factor 10 | 1,400
GPCR 1 | 408
Ion Channel 1 | 344

WikiPathways Pathway

Human Thyroid Stimulating Horm... 68 | 68
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calsenilin KCNIP3 Tbio Ion Channel -1.72310 56.0 369
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Transcription termination factor 2 TTF2 Tbio Non-IDG -0.36173 2.95 140
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Glycoprotein hormones alpha chain CGA Tbio Non-IDG -2.62079 405.6 915
Ral guanine nucleotide dissociation stimulator RALGDS Tbio Non-IDG -2.85677 683.6 102
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509
Paired box protein Pax-8 PAX8 Tbio Transcription Factor -2.64765 442.1 540