Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
decreased circulating glucose ... 1 | 126
embryonic lethality prior to t... 1 | 278
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 9 | 11,493
lung cancer 9 | 4,740
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 8 | 4,104
malignant mesothelioma 8 | 3,232
ovarian cancer 8 | 8,520
Cancer 7 | 2,499
Nijmegen breakage syndrome 7 | 24
psoriasis 7 | 6,694
Breast cancer 6 | 3,578
osteosarcoma 6 | 7,950
Ataxia telangiectasia 5 | 34
Autosomal recessive predisposition 5 | 1,442
Hereditary Breast and Ovarian Cancer Syndrome 5 | 14
Short stature 5 | 531
medulloblastoma, large-cell 5 | 6,241
Chromosome Breakage 4 | 36
Dull intelligence 4 | 645
Increased chromosomal breakage 4 | 27
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Microcephaly 4 | 166
Poor school performance 4 | 645
Small head 4 | 374
Xeroderma pigmentosum 4 | 43
ependymoma 4 | 4,679
non primary Sjogren syndrome sicca 4 | 891
Acquired scoliosis 3 | 281
Bloom syndrome 3 | 29
Breast Neoplasms 3 | 445
Curvature of spine 3 | 282
Decreased platelet count 3 | 111
Fanconi anemia 3 | 56
Liver cancer 3 | 604
Malignant neoplasm of breast 3 | 15
Mammary Neoplasms 3 | 425
Prostatic Neoplasms 3 | 495
Telangiectasis 3 | 36
Thrombocytopenia 3 | 197
Werner syndrome 3 | 29
colon cancer 3 | 1,478
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Anemia 2 | 365
Carcinoma of colon 2 | 32
Carcinoma, Squamous Cell 2 | 110
Chronic Lymphocytic Leukemia 2 | 262
Cognitive delay 2 | 608
Colorectal Neoplasms 2 | 243
Dysarthria 2 | 192
Dystonia 2 | 164
Dystonic disease 2 | 106
Elevated hepatic transaminases 2 | 81
Endometrial cancer 2 | 311
Glioma 2 | 74
Hepatic enzyme increased 2 | 81
Hypoplastic mandible condyle 2 | 275
Irregular hyperpigmentation 2 | 33
Leukopenia 2 | 72
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Lung Neoplasms 2 | 232
Lymphoma 2 | 81
Lymphoma, Non-Hodgkin 2 | 24
Lynch syndrome 2 | 35
Malignant lymphoma, non-Hodgkin 2 | 4
Mental and motor retardation 2 | 608
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Pick disease 2 | 1,894
Polycystic ovary syndrome 2 | 360
Prostate cancer 2 | 175
Schizophrenia 2 | 1,160
Short palpebral fissure 2 | 38
Spider Veins 2 | 17
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Waldenstrons macroglobulinemia 2 | 765
Xeroderma pigmentosum variant type 2 | 4
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 807
hypopigmented skin patch 2 | 59
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
oligodendroglioma 2 | 2,850
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 4 | 4,145
Kinase 1 | 634

WikiPathways Pathway

Homologous recombination 14 | 14
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA repair and recombination protein RAD54B RAD54B Tbio Non-IDG -1.41173 28.9 153
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Fibrinogen silencer-binding protein RAD54B Tbio Non-IDG -0.93952 9.22 38
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459
DNA repair protein RAD51 homolog 1 RAD51 Tchem Non-IDG -3.82649 6590.0 594
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Nibrin NBN Tbio Non-IDG -1.95649 97.2 1094