Development Level

Tchem 27 | 1,598
Tbio 17 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal heart morphology 2 | 162
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
small seminal vesicle 1 | 10
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Cancer 46 | 2,499
Carcinoma 42 | 11,493
ovarian cancer 38 | 8,520
osteosarcoma 32 | 7,950
psoriasis 31 | 6,694
glioblastoma 29 | 5,792
lung cancer 28 | 4,740
Breast cancer 25 | 3,578
atypical teratoid / rhabdoid tumor 24 | 5,112
medulloblastoma, large-cell 23 | 6,241
diabetes mellitus 22 | 1,728
ependymoma 22 | 4,679
malignant mesothelioma 20 | 3,232
pancreatic cancer 20 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Astrocytoma, Pilocytic 18 | 3,081
Prostatic Neoplasms 17 | 495
Stomach Neoplasms 17 | 300
adult high grade glioma 17 | 3,801
tuberculosis 17 | 2,010
ulcerative colitis 17 | 1,819
Arthritis 16 | 290
Kidney disease 16 | 430
Schizophrenia 16 | 1,160
Vascular disease 16 | 319
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
Breast Neoplasms 15 | 445
Lung Neoplasms 15 | 232
breast carcinoma 15 | 1,638
Asthma 14 | 385
Carcinoma, Squamous Cell 14 | 110
Lung disease 14 | 142
Mammary Neoplasms 14 | 425
Squamous cell carcinoma 14 | 129
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
non-small cell lung cancer 14 | 2,890
oligodendroglioma 14 | 2,850
Alzheimer's disease 13 | 658
Carcinoma, Hepatocellular 13 | 228
Cell Transformation, Neoplastic 13 | 97
Depressive disorder 13 | 409
Liver carcinoma 13 | 240
Neoplastic Cell Transformation 13 | 89
Rheumatoid arthritis 13 | 1,191
colon cancer 13 | 1,478
invasive ductal carcinoma 13 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Colonic Neoplasms 12 | 142
Heart disease 12 | 306
Inflammatory bowel disease 12 | 151
Mental Depression 12 | 333
Neoplasm Metastasis 12 | 168
acute quadriplegic myopathy 12 | 1,158
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pituitary cancer 12 | 1,972
Adenocarcinoma 11 | 122
Adenoma 11 | 167
Anemia 11 | 365
Atherosclerosis 11 | 291
Brain Ischemia 11 | 110
Colorectal Neoplasms 11 | 243
Hypertension 11 | 396
Kidney cancer 11 | 2,613
Liver Cirrhosis, Experimental 11 | 769
Liver disease 11 | 237
Pancreatic Neoplasm 11 | 85
Pancreatic Neoplasms 11 | 85
astrocytoma 11 | 1,146
cystic fibrosis 11 | 1,696
non-small cell lung carcinoma 11 | 317
primitive neuroectodermal tumor 11 | 3,035
Carcinoma, Non-Small-Cell Lung 10 | 107
Hyperglycemia 10 | 137
Hypertensive disease 10 | 292
Obesity 10 | 678
Toxic encephalopathy 10 | 141
group 4 medulloblastoma 10 | 1,855
interstitial cystitis 10 | 2,312
Brain disease 9 | 96
Eye disease 9 | 62
Hypersensitivity reaction type II disease 9 | 253
Multiple myeloma 9 | 1,332
Parkinson's disease 9 | 392
Reperfusion Injury 9 | 86
adrenocortical carcinoma 9 | 1,428
dermatomyositis 9 | 966
hepatocellular carcinoma 9 | 547
nasopharyngeal carcinoma 9 | 1,058
subependymal giant cell astrocytoma 9 | 2,287
Bipolar Disorder 8 | 666
Coronary artery disease 8 | 268
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Endometriosis 8 | 540
Seizures 8 | 596
active Crohn's disease 8 | 922
astrocytic glioma 8 | 2,597
juvenile dermatomyositis 8 | 1,187

Tissue

Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Female tissues 50 | 17,400
Liver and Pancreas 50 | 16,750
Male tissues 50 | 17,142
Skin and soft tissues 50 | 17,230
Urinary Tract 50 | 16,678
Blood and immune system 49 | 16,909
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 20 | 12,091
Enzyme 12 | 4,145
Transcription Factor 11 | 1,400
Kinase 6 | 634
GPCR 1 | 408

WikiPathways Pathway

Hepatitis C and Hepatocellular... 50 | 50
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
CD44 antigen CD44 Tbio Non-IDG -3.85987 6832.7 3401
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762