Development Level

Tbio 8 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal vitreous body morphol... 1 | 10
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Porphyria 8 | 10
osteosarcoma 8 | 7,950
Hereditary coproporphyria 7 | 8
Acute intermittent porphyria 6 | 15
Carcinoma 6 | 11,493
Erythropoietic protoporphyria 6 | 15
Photosensitivity of skin 6 | 51
Variegate Porphyria 6 | 10
ovarian cancer 6 | 8,520
Porphyria cutanea tarda 5 | 12
Abdominal Pain 4 | 98
Anemia 4 | 365
Anemia, Hemolytic 4 | 55
Constipation 4 | 181
Cutaneous porphyria 4 | 6
Dyschezia 4 | 135
Vomiting 4 | 116
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
psoriasis 4 | 6,694
Abnormal blistering of the skin 3 | 54
Autosomal recessive predisposition 3 | 1,442
Blister of skin 3 | 54
Diarrhea 3 | 253
Elevated heart rate 3 | 25
Hypertensive disease 3 | 292
Peripheral Neuropathy 3 | 134
Respiratory Paralysis 3 | 7
Skin bulla 3 | 54
Tachycardia 3 | 43
Thin skin 3 | 47
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Abnormality of the heme biosynthetic pathway 2 | 3
Acute episodes of neuropathic symptoms 2 | 2
Alopecia 2 | 115
Anxiety 2 | 136
Anxiety disease 2 | 113
Childhood onset 2 | 38
Cholelithiasis 2 | 33
Depressive disorder 2 | 409
Elevated urinary delta-aminolevulinic acid 2 | 3
Hepatoerythropoietic porphyria 2 | 5
Hypertrichosis 2 | 46
Increase in blood pressure 2 | 119
Increased hepatocellular carcinoma risk 2 | 27
Increased incidence of hepatocellular carcinoma 2 | 27
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Muscle Weakness 2 | 170
Myalgia 2 | 54
Nausea and vomiting 2 | 97
Neuropathy 2 | 261
Paresthesia 2 | 32
Psychotic Disorders 2 | 151
Scleroderma 2 | 7
Scleroderma-like secondary cutaneous sclerosis 2 | 7
Seizures 2 | 596
Sideroblastic anemia 2 | 20
Sleeplessness 2 | 16
Splenomegaly 2 | 190
Urine color abnormal 2 | 6
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
subependymal giant cell astrocytoma 2 | 2,287
Anorexia 1 | 43
Cicatrization 1 | 3
Collapse of vertebra 1 | 14
Compression fracture of vertebral column 1 | 14
Confusion 1 | 21
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Edema 1 | 81
Erythema 1 | 58
Flushing 1 | 60
Fragile skin 1 | 18
Head and Neck Neoplasms 1 | 26
Hyperpigmented macules 1 | 42
Hypertriglyceridemia result 1 | 37
Inverted follicular keratosis 1 | 3
Irritation - emotion 1 | 68
Liver Neoplasms, Experimental 1 | 59
Meningioma 1 | 41
Microcytic hypochromic anemia (disorder) 1 | 10
Nausea 1 | 20
Respiratory Distress Syndrome, Adult 1 | 40
Tyrosinemia 1 | 10
X- linked recessive 1 | 110
X-linked sideroblastic anemia 1 | 4
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 9 | 16,909
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Cardiovascular System 8 | 15,192
Nervous System 8 | 16,725

Target Family

Enzyme 9 | 4,145

WikiPathways Pathway

Heme Biosynthesis 9 | 9
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.05504 112.4 87
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.47389 296.8 173
Porphobilinogen deaminase HMBS Tbio Enzyme -2.78202 588.5 255
5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 Tbio Enzyme -2.18341 149.7 219
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -3.02024 1068.6 166
Uroporphyrinogen-III synthase UROS Tbio Enzyme -2.48982 310.9 67
Ferrochelatase, mitochondrial FECH Tbio Enzyme -2.73759 528.2 136
Uroporphyrinogen decarboxylase UROD Tbio Enzyme -2.94694 872.4 188