Development Level

Tbio 26 | 11,445
Tclin 8 | 613
Tchem 6 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal epididymis morphology 1 | 42
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal ovary morphology 1 | 7
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
absent epididymis 1 | 3
decreased bone mineral content 1 | 151
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
female infertility 1 | 60
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Cancer 32 | 2,499
Carcinoma 26 | 11,493
osteosarcoma 24 | 7,950
glioblastoma 17 | 5,792
lung cancer 16 | 4,740
malignant mesothelioma 16 | 3,232
ovarian cancer 16 | 8,520
psoriasis 16 | 6,694
Anemia 15 | 365
lung carcinoma 15 | 2,843
non-small cell lung cancer 14 | 2,890
Thrombocytopenia 13 | 197
Breast cancer 12 | 3,578
interstitial cystitis 12 | 2,312
ulcerative colitis 12 | 1,819
adult high grade glioma 11 | 3,801
tuberculosis 11 | 2,010
Astrocytoma, Pilocytic 10 | 3,081
Breast Neoplasms 9 | 445
Kidney cancer 9 | 2,613
Liver Cirrhosis, Experimental 9 | 769
Mammary Neoplasms 9 | 425
Rheumatoid arthritis 9 | 1,191
ependymoma 9 | 4,679
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
medulloblastoma, large-cell 9 | 6,241
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
Cerebrovascular disease 8 | 238
Schizophrenia 8 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Alzheimer's disease 7 | 658
Arthritis 7 | 290
Asthma 7 | 385
Leukemia, Myelocytic, Acute 7 | 120
Multiple Sclerosis 7 | 540
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
group 3 medulloblastoma 7 | 4,104
invasive ductal carcinoma 7 | 2,951
periodontitis 7 | 293
Acquired immunodeficiency syndrome 6 | 197
Brain Injuries 6 | 65
Coronary artery disease 6 | 268
Fever 6 | 138
Heart disease 6 | 306
Hypersensitivity reaction type II disease 6 | 253
Leukemia, Myeloid, Acute 6 | 105
Melanoma 6 | 711
Multiple myeloma 6 | 1,332
Myocardial Infarction 6 | 151
Neutropenia 6 | 72
Thrombocytosis 6 | 38
colon cancer 6 | 1,478
primary Sjogren syndrome 6 | 735
spina bifida 6 | 1,074
Allergic hypersensitivity disease 5 | 126
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Bleeding time prolonged 5 | 31
Cell Transformation, Neoplastic 5 | 97
Depressive disorder 5 | 409
Dermatitis 5 | 157
Diarrhea 5 | 253
Down syndrome 5 | 499
Epistaxis 5 | 43
Fatigue 5 | 182
Hypereosinophilic syndrome 5 | 71
Hypertension 5 | 396
Inflammation 5 | 120
Inflammatory bowel disease 5 | 151
Leukopenia 5 | 72
Liver disease 5 | 237
Malaria 5 | 160
Myocardial Ischemia 5 | 169
Neuropathy 5 | 261
Peripheral vascular disease 5 | 87
Prostatic Neoplasms 5 | 495
Pulmonary Fibrosis 5 | 106
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid / rhabdoid tumor 5 | 5,112
breast carcinoma 5 | 1,638
pituitary cancer 5 | 1,972
Allergic rhinitis 4 | 94
Endometriosis 4 | 540
Hemoglobin low 4 | 124
Kidney disease 4 | 430
Leishmaniasis 4 | 47
Lung Neoplasms 4 | 232
Lung disease 4 | 142
Mental Depression 4 | 333
Parkinson's disease 4 | 392
Reperfusion Injury 4 | 86
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 39 | 16,909
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Male tissues 37 | 17,142
Respiratory system 37 | 16,393
Digestive Tract 36 | 17,369
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Liver and Pancreas 35 | 16,750
Nervous System 35 | 16,725
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 20 | 12,091
Transcription Factor 14 | 1,400
Enzyme 2 | 4,145
Kinase 2 | 634
GPCR 1 | 408
Ion Channel 1 | 344

WikiPathways Pathway

Hematopoietic Stem Cell Differ... 40 | 40
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Friend leukemia integration 1 transcription factor FLI1 Tbio Transcription Factor -1.82504 66.8 454
Histo-blood group ABO system transferase ABO Tbio Enzyme 0.00000 0
Max-interacting protein 1 MXI1 Tbio Transcription Factor -2.03408 107.7 179
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Potassium voltage-gated channel subfamily H member 2 KCNH2 Tclin Ion Channel -3.22575 1653.9 243
Protein CBFA2T3 CBFA2T3 Tbio Non-IDG -1.80148 64.9 82
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Serine/threonine-protein kinase RIO3 RIOK3 Tchem Kinase -1.08927 12.4 142
Tripartite motif-containing protein 29 TRIM29 Tbio Non-IDG -1.42599 31.3 334