Development Level

Tbio 11 | 11,651
Tchem 4 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal stomach morphology 1 | 10
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Carcinoma 14 | 11,493
osteosarcoma 11 | 7,950
Cancer 9 | 2,499
Gastrointestinal Stromal Tumors 9 | 48
Polydactyly 9 | 107
Abnormally small eyeball 8 | 97
Decreased size of eyeball 8 | 97
Microphthalmos 8 | 100
Nevoid basal cell carcinoma syndrome 8 | 16
atypical teratoid / rhabdoid tumor 8 | 5,112
psoriasis 8 | 6,694
Kidney cancer 7 | 2,613
ovarian cancer 7 | 8,520
Cleft Lip 6 | 141
Highly variable severity 6 | 157
Orbital separation excessive 6 | 244
Variable expressivity 6 | 157
Acquired scoliosis 5 | 281
Basal cell carcinoma 5 | 54
Brachydactyly 5 | 156
Broad flat nasal bridge 5 | 236
Carcinoma, Basal Cell 5 | 28
Cleft Palate 5 | 271
Curvature of spine 5 | 282
Holoprosencephaly 5 | 56
Hydrocephalus 5 | 152
Intellectual disability 5 | 1,016
Nasal bridge wide 5 | 236
Short stature 5 | 531
Strabismus 5 | 270
lung cancer 5 | 4,740
medulloblastoma 5 | 720
medulloblastoma, large-cell 5 | 6,241
Basal Cell Nevus Syndrome 4 | 5
Basal cell nevi 4 | 23
Big calvaria 4 | 147
Cognitive delay 4 | 608
Coloboma of iris 4 | 38
Congenital hemivertebra 4 | 25
Dull intelligence 4 | 645
Epilepsy 4 | 792
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Pallister-Hall syndrome 4 | 10
Poor school performance 4 | 645
Seizures 4 | 596
Short 4th metacarpal 4 | 7
Short ribs 4 | 30
Syndactyly of the toes 4 | 45
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
pancreatic cancer 4 | 2,398
spina bifida 4 | 1,074
subependymal giant cell astrocytoma 4 | 2,287
Accessory rib 3 | 10
Acute Promyelocytic Leukemia 3 | 40
Alobar Holoprosencephaly 3 | 14
Breast cancer 3 | 3,578
Class III malocclusion 3 | 78
Coarse facial features 3 | 108
Fused vertebrae 3 | 25
Glaucoma 3 | 239
Hypertrophy of lower jaw 3 | 78
Hypotrichosis 1 3 | 15
Increased size of mandible 3 | 78
Kyphoscoliosis deformity of spine 3 | 60
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Leukemia, Promyelocytic, Acute 3 | 36
Macrotia 3 | 87
Mandibular hyperplasia 3 | 78
Melanocytic nevus 3 | 43
Milium Cyst 3 | 16
Motor delay 3 | 147
No development of motor milestones 3 | 147
Noncancerous mole 3 | 28
Ovarian Fibromata 3 | 3
Semilobar Holoprosencephaly 3 | 14
Short nose 3 | 132
Skin tag 3 | 14
Small nose 3 | 132
Spinal fusion 3 | 25
Sprengel deformity 3 | 16
Syndactyly of fingers 3 | 48
Synostosis 3 | 15
Thickened facial skin with coarse facial features 3 | 108
Vertebral body fusion 3 | 25
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
mandibular excess (physical finding) 3 | 78

Tissue

Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 8 | 12,091
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,145
GPCR 1 | 408

WikiPathways Pathway

Hedgehog Signaling Pathway 16 | 16
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.93639 70.1 171
Suppressor of fused homolog SUFU Tbio Non-IDG -2.33544 208.6 168
Desert hedgehog protein DHH Tbio Non-IDG -2.26501 171.2 318
Beta-adrenergic receptor kinase 1 GRK2 Tchem Kinase -2.61043 428.8 455
Zinc finger protein GLI2 GLI2 Tchem Transcription Factor -2.58228 355.0 196
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.19296 1388.8 190
Zinc finger protein GLI1 GLI1 Tchem Transcription Factor -3.04303 1054.8 450
Aryl hydrocarbon receptor nuclear translocator-like protein 1 ARNTL Tbio Transcription Factor -2.83548 672.9 330
Histone deacetylase complex subunit SAP18 SAP18 Tbio Enzyme -1.18609 14.6 125