Development Level

Tbio 11 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

embryonic lethality prior to t... 3 | 187
preweaning lethality, complete... 3 | 633
abnormal QRS complex 1 | 25
abnormal embryo development 1 | 2
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placenta size 1 | 10
abnormal spinal cord morpholog... 1 | 8
abnormal stomach morphology 1 | 4
absent heartbeat 1 | 6
anophthalmia 1 | 20
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating glucose ... 1 | 121
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
enlarged lymph nodes 1 | 27
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased heart rate variabili... 1 | 4
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13

Disease

osteosarcoma 11 | 7,933
Cancer 8 | 2,346
Carcinoma 8 | 2,147
Nevoid basal cell carcinoma syndrome 8 | 9
Polydactyly 8 | 93
psoriasis 8 | 6,685
atypical teratoid / rhabdoid tumor 7 | 4,369
ovarian cancer 7 | 8,484
sonic hedgehog group medulloblastoma 6 | 1,482
Basal cell carcinoma 5 | 29
Holoprosencephaly 5 | 52
Pallister-Hall syndrome 5 | 11
Synostosis 5 | 18
medulloblastoma, large-cell 5 | 6,234
Basal Cell Nevus Syndrome 4 | 4
glioblastoma 4 | 5,572
lung cancer 4 | 4,466
subependymal giant cell astrocytoma 4 | 2,287
Acute Promyelocytic Leukemia 3 | 31
Alobar Holoprosencephaly 3 | 14
Ameloblastoma 3 | 25
Cleft Lip 3 | 91
Cleft palate 3 | 125
Lobar Holoprosencephaly 3 | 14
SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR 3 | 14
Semilobar Holoprosencephaly 3 | 14
Skin Neoplasms 3 | 49
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
medulloblastoma 3 | 1,524
Acrocallosal syndrome 2 | 12
Amyotrophic Lateral Sclerosis 2 | 431
Basal cell carcinoma of skin 2 | 2
Brain Neoplasms 2 | 23
Breast cancer 2 | 3,094
Endometriosis 2 | 535
Hypogonadism 2 | 70
Hypospadias 2 | 65
Imperforate anus 2 | 14
Joubert syndrome 2 | 61
Neuroectodermal Tumor, Primitive 2 | 8
Obesity 2 | 616
Rett syndrome 2 | 18
VACTERL association 2 | 23
diabetes mellitus 2 | 1,663
ependymoma 2 | 2,514
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
malignant mesothelioma 2 | 3,162
non primary Sjogren syndrome sicca 2 | 840
pancreatic cancer 2 | 2,300
pediatric high grade glioma 2 | 2,712
primary pancreatic ductal adenocarcinoma 2 | 1,271
primitive neuroectodermal tumor 2 | 3,031
46 XY gonadal dysgenesis 1 | 9
Achondroplasia 1 | 20
Adenoid hypertrophy 1 | 4
Angioma serpiginosum 1 | 3
Asphyxiating thoracic dystrophy 1 | 32
BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1 1 | 1
CHARGE syndrome 1 | 23
Cardiomegaly 1 | 66
Choanal atresia 1 | 19
Chondrodysplasia Blomstrand type 1 | 2
Coloboma 1 | 51
Congenital Abnormality 1 | 11
Congenital ocular coloboma (disorder) 1 | 12
Diffuse large B-cell lymphoma 1 | 41
Embryo Loss 1 | 9
Esophageal atresia 1 | 25
Familial adenomatous polyposis 1 | 31
Fibroma 1 | 16
Focal dermal hypoplasia 1 | 9
Frontotemporal dementia 1 | 41
Goldenhar syndrome 1 | 19
HOLOPROSENCEPHALY 7 1 | 1
Hypopigmentation disorder 1 | 2
Hypopituitarism 1 | 36
Jaw Abnormalities 1 | 5
Kidney cancer 1 | 118
Klinefelter's syndrome 1 | 59
MACROSTOMIA, ISOLATED 1 | 2
Macrostomia 1 | 2
Maffucci syndrome 1 | 7
Meningioma 1 | 26
Multiple endocrine neoplasia type 2A 1 | 22
Myocardial Infarction 1 | 126
Newborn respiratory distress syndrome 1 | 8
Ollier disease 1 | 15
Osteochondrosis 1 | 14
Ovarian Cysts 1 | 34
Pseudohermaphroditism 1 | 16
Pulmonary function (finding) 1 | 33
Pyelonephritis 1 | 12
Rhabdomyosarcoma 1 | 29
Seasonal affective disorder 1 | 25
Swyer Syndrome 1 | 8
Testicular thecoma 1 | 1
Tinea capitis 1 | 12
Xeroderma pigmentosum 1 | 41

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Non-IDG 8 | 11,971
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,146
GPCR 1 | 406

WikiPathways Pathway

Hedgehog Signaling Pathway 16 | 16
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17963 1388.1 188
Zinc finger protein GLI2 GLI2 Tchem Transcription Factor -2.51321 325.2 174
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.75559 47.6 77
Smoothened homolog SMO Tclin GPCR -1.11355 12.5 388
Suppressor of fused homolog SUFU Tbio Non-IDG -2.26339 185.5 162
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.09626 1236.4 412
Beta-adrenergic receptor kinase 1 GRK2 Tchem Kinase -2.57168 411.5 399
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.87324 62.9 159
Desert hedgehog protein DHH Tbio Non-IDG -2.18479 152.9 260
Aryl hydrocarbon receptor nuclear translocator-like protein 1 ARNTL Tbio Transcription Factor -2.76919 607.4 283