Development Level

Tbio 33 | 11,445
Tchem 9 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased total body fat amoun... 3 | 134
abnormal optic disc morphology 2 | 10
corneal opacity 2 | 32
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased heart left ventricle... 1 | 28
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
fused cornea and lens 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
iris synechia 1 | 3
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 31 | 11,493
Cancer 25 | 2,499
osteosarcoma 23 | 7,950
ovarian cancer 23 | 8,520
Breast cancer 21 | 3,578
Congenital heart disease 20 | 93
psoriasis 20 | 6,694
medulloblastoma, large-cell 18 | 6,241
lung cancer 17 | 4,740
malignant mesothelioma 17 | 3,232
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 15 | 4,679
glioblastoma 15 | 5,792
lung adenocarcinoma 12 | 2,716
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
Kidney cancer 10 | 2,613
Short stature 10 | 531
cystic fibrosis 10 | 1,696
interstitial cystitis 10 | 2,312
invasive ductal carcinoma 10 | 2,951
Cleft Palate 9 | 271
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Tetralogy of Fallot 9 | 63
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung carcinoma 9 | 2,843
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
Bilateral fifth finger clinodactyly 8 | 110
Brachydactyly 8 | 156
Craniofacial Abnormalities 8 | 151
Curvature of little finger 8 | 110
Fetal Growth Retardation 8 | 189
Infant, Small for Gestational Age 8 | 176
Intrauterine retardation 8 | 176
Orbital separation excessive 8 | 244
Osteoporosis 8 | 363
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Astrocytoma, Pilocytic 7 | 3,081
Cryptorchidism 7 | 296
Decreased projection of midface 7 | 105
Exophthalmos 7 | 112
Heart disease 7 | 306
Hypotrophic midface 7 | 105
Intellectual disability 7 | 1,016
Midface retrusion 7 | 105
Patent ductus arteriosus 7 | 90
Prominent eyes 7 | 96
Prominent globes 7 | 96
Protruding eyes 7 | 96
Small head 7 | 374
Small midface 7 | 105
Vascular disease 7 | 319
Ventricular Septal Defects 7 | 119
adult high grade glioma 7 | 3,801
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
gastric carcinoma 7 | 807
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
oligodendroglioma 7 | 2,850
Bipolar Disorder 6 | 666
Broad forehead 6 | 59
Dull intelligence 6 | 645
Hypotrophic malar bone 6 | 129
Low intelligence 6 | 645
Malar flattening 6 | 129
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Pick disease 6 | 1,894
Poor school performance 6 | 645
Schizophrenia 6 | 1,160
Strabismus 6 | 270
astrocytic glioma 6 | 2,597
group 4 medulloblastoma 6 | 1,855
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Alzheimer's disease 5 | 658
Aortic coarctation 5 | 30
Autosomal recessive predisposition 5 | 1,442
Cataract 5 | 297
Cleft Lip 5 | 141
Congenital Epicanthus 5 | 177
Epilepsy 5 | 792
Hypoplastic mandible condyle 5 | 275
Low set ears 5 | 181
Lung Neoplasms 5 | 232
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
colon cancer 5 | 1,478
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074
tuberculosis 5 | 2,010

Tissue

Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Digestive Tract 41 | 17,369
Liver and Pancreas 41 | 16,750
Male tissues 40 | 17,142
Cardiovascular System 39 | 15,192
Skin and soft tissues 39 | 17,230
Urinary Tract 38 | 16,678
Blood and immune system 36 | 16,909
Respiratory system 36 | 16,393
Nervous System 35 | 16,725

Target Family

Transcription Factor 27 | 1,400
Non-IDG 11 | 12,091
Kinase 4 | 634
Enzyme 1 | 4,145
Epigenetic 1 | 242

WikiPathways Pathway

Heart Development 44 | 44
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
T-box transcription factor TBX1 TBX1 Tbio Transcription Factor -1.99519 95.5 207
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Vascular endothelial growth factor C VEGFC Tbio Non-IDG -2.99495 1028.1 667
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
Class E basic helix-loop-helix protein 40 BHLHE40 Tbio Transcription Factor -1.77841 66.6 224