Development Level

Tbio 34 | 11,445
Tchem 15 | 1,598

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal QT variability 2 | 10
cataract 2 | 92
decreased total body fat amoun... 2 | 207
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
increased body temperature 1 | 9
increased circulating alkaline... 1 | 122
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 36 | 11,493
ovarian cancer 27 | 8,520
lung cancer 22 | 4,740
psoriasis 21 | 6,694
Autosomal recessive predisposition 20 | 1,442
glioblastoma 16 | 5,792
non-small cell lung cancer 16 | 2,890
osteosarcoma 16 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Cancer 15 | 2,499
medulloblastoma, large-cell 15 | 6,241
pancreatic cancer 15 | 2,398
Multiple myeloma 14 | 1,332
atypical teratoid / rhabdoid tumor 14 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung adenocarcinoma 14 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Hypoglycemia 12 | 152
astrocytic glioma 12 | 2,597
diabetes mellitus 12 | 1,728
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
Cognitive delay 11 | 608
Epilepsy 11 | 792
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
adrenocortical carcinoma 11 | 1,428
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
Seizures 10 | 596
adult high grade glioma 10 | 3,801
ductal carcinoma in situ 10 | 1,745
Acidosis, Lactic 9 | 97
Glycogen storage disease 9 | 39
Liver Cirrhosis, Experimental 9 | 769
Liver carcinoma 9 | 240
Obesity 9 | 678
Pick disease 9 | 1,894
lung carcinoma 9 | 2,843
primitive neuroectodermal tumor 9 | 3,035
Breast Neoplasms 8 | 445
Breast cancer 8 | 3,578
Carcinoma, Hepatocellular 8 | 228
Dull intelligence 8 | 645
Icterus 8 | 82
Intellectual disability 8 | 1,016
Lactic acidemia 8 | 95
Lactic acidosis 8 | 51
Low intelligence 8 | 645
Mammary Neoplasms 8 | 425
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Schizophrenia 8 | 1,160
breast carcinoma 8 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
oligodendroglioma 8 | 2,850
Adenocarcinoma of lung 7 | 142
Astrocytoma, Pilocytic 7 | 3,081
Diabetes Mellitus, Experimental 7 | 108
Hyperglycemia 7 | 137
Waldenstrons macroglobulinemia 7 | 765
acute quadriplegic myopathy 7 | 1,158
dermatomyositis 7 | 966
group 4 medulloblastoma 7 | 1,855
primary pancreatic ductal adenocarcinoma 7 | 1,109
Alzheimer's disease 6 | 658
Congenital hemolytic anemia 6 | 32
Disease Models, Animal 6 | 155
Hepatomegaly 6 | 285
Muscle hypotonia 6 | 571
Myocardial Ischemia 6 | 169
Osteoporosis 6 | 363
Pyruvate decarboxylase deficiency 6 | 16
Splenomegaly 6 | 190
Cerebellar Ataxia 5 | 304
Cholecystitis 5 | 18
Cholelithiasis 5 | 33
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Dystonia 5 | 164
Hyperinsulinism 5 | 133
Impaired exercise tolerance 5 | 42
Kidney cancer 5 | 2,613
Leigh disease 5 | 100
Small head 5 | 374
Stomach Neoplasms 5 | 300
nephrosclerosis 5 | 333
ulcerative colitis 5 | 1,819
Alzheimer Disease 4 | 83
Dystonic disease 4 | 106
Highly variable severity 4 | 157
Male infertility 4 | 206
Mouth Neoplasms 4 | 55
Neoplasm Invasiveness 4 | 161
Variable expressivity 4 | 157
colon cancer 4 | 1,478
interstitial cystitis 4 | 2,312
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010

Tissue

Endocrine System 48 | 18,159
Digestive Tract 47 | 17,369
Liver and Pancreas 47 | 16,750
Skin and soft tissues 47 | 17,230
Urinary Tract 47 | 16,678
Blood and immune system 46 | 16,909
Female tissues 46 | 17,400
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Cardiovascular System 43 | 15,192
Respiratory system 42 | 16,393

Target Family

Enzyme 30 | 4,145
Kinase 12 | 634
Transporter 5 | 473
Non-IDG 2 | 12,091

WikiPathways Pathway

Glycolysis and Gluconeogenesis 49 | 49
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.25018 186.1 256
Aspartate aminotransferase, mitochondrial GOT2 Tbio Enzyme -3.23630 1435.0 450
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.64656 428.3 291
ATP-dependent 6-phosphofructokinase, muscle type PFKM Tbio Kinase -2.50086 308.0 311
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT Tbio Enzyme -2.37343 242.5 196
Solute carrier family 2, facilitated glucose transporter member 3 SLC2A3 Tchem Transporter -2.44339 254.3 231