Development Level

Tbio 10 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

decreased body weight 2 | 161
decreased circulating alkaline... 2 | 46
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal gait 1 | 69
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased mature B cell number 1 | 7
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
enlarged heart 1 | 210
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 12 | 11,493
Kidney cancer 8 | 2,613
lung cancer 8 | 4,740
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
glioblastoma 6 | 5,792
medulloblastoma, large-cell 6 | 6,241
ovarian cancer 6 | 8,520
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
adult high grade glioma 5 | 3,801
colon cancer 5 | 1,478
ependymoma 5 | 4,679
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
Breast cancer 4 | 3,578
Cancer 4 | 2,499
Liver cancer 4 | 604
Melanoma 4 | 711
Skin cancer 4 | 469
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
ulcerative colitis 4 | 1,819
Autosomal recessive predisposition 3 | 1,442
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
primitive neuroectodermal tumor 3 | 3,035
Abnormality of the fingernails 2 | 51
Bipolar Disorder 2 | 666
Essential Hypertension 2 | 94
Obesity 2 | 678
Osteoporosis 2 | 363
Pick disease 2 | 1,894
Schizophrenia 2 | 1,160
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
urothelial carcinoma 2 | 318
Abnormal respiratory patterns 1 | 20
Abnormal vision 1 | 52
Autosomal recessive polycystic kidney disease 1 | 41
Bronchiolitis 1 | 18
Cellulitis 1 | 20
Cerebral cortex myoclonus 1 | 3
Charcot-Marie-Tooth disease dominant intermediate F 1 | 3
Cholera 1 | 34
Chronic kidney disease stage 5 1 | 31
Colon diverticulum anatomic structure 1 | 15
DOID:2415 1 | 5
Decreased IgM 1 | 11
Diverticular disease of colon 1 | 15
Edema 1 | 81
Fibrous dysplasia 1 | 15
HYPOCALCEMIA, AUTOSOMAL DOMINANT 1 1 | 2
HYPOCALCEMIA, AUTOSOMAL DOMINANT 2 1 | 1
HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder) 1 | 1
Hemangiosarcoma 1 | 18
Hereditary spherocytosis type 1 1 | 23
Hypercalciuria 1 | 27
Hyperglycemia 1 | 137
Hypermagnesiuria 1 | 3
Hyperphosphatemia (disorder) 1 | 17
Hypocalcemia 1 | 32
Hypocalciuric hypercalcemia, familial, type II 1 | 1
Hypomagnesemia 1 | 12
Hypotension 1 | 82
Increased calcium level in kidney 1 | 21
Inflammatory Bowel Diseases 1 | 35
Insulinoma 1 | 24
Koilonychia 1 | 7
Leukonychia 1 | 6
Malignant melanoma of choroid 1 | 3
Malignant melanoma of ciliary body 1 | 3
Malignant melanoma of iris 1 | 4
McCune Albright syndrome 1 | 19
Myasthenias 1 | 8
Nail disease 1 | 9
Nephrotic Syndrome 1 | 78
Ocular cancer 1 | 7
Organic writer's cramp 1 | 10
Pain 1 | 103
Pertussis 1 | 20
Phakomatosis cesioflammea 1 | 2
Phakomatosis cesiomarmorata 1 | 1
Polycystic liver disease 1 | 16
Pseudohypoparathyroidism 1 | 18
Reflex sympathetic dystrophy 1 | 7
SERUM PHOSPHATE ELEVATED 1 | 14
Seasonal affective disorder 1 | 28
Severe Dengue 1 | 3
Type 1 diabetes mellitus 1 | 109
Uveal melanoma 1 | 20
esophageal cancer 1 | 22

Tissue

Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Skin and soft tissues 15 | 17,230
Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Urinary Tract 14 | 16,678
Male tissues 13 | 17,142

Target Family

Enzyme 11 | 4,145
Non-IDG 2 | 12,091
GPCR 1 | 408
Ion Channel 1 | 344

WikiPathways Pathway

GPR40 Pathway 15 | 15
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

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