Development Level

Tchem 80 | 1,885
Tclin 75 | 612
Tdark 59 | 6,569
Tbio 44 | 11,178

Collection

GPCR: IDG Consortium (Targets) 40 | 126
GPCR: IDG Consortium (Complete... 11 | 25

IMPC Phenotype

decreased vertical activity 7 | 208
abnormal behavior 5 | 298
enlarged heart 5 | 210
hyperactivity 5 | 148
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 4 | 499
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
improved glucose tolerance 3 | 79
increased circulating sodium l... 3 | 71
preweaning lethality, complete... 3 | 979
abnormal behavioral response t... 2 | 66
abnormal kidney morphology 2 | 65
abnormal skin coloration 2 | 25
abnormal skin morphology 2 | 50
decreased circulating alanine ... 2 | 47
increased circulating creatini... 2 | 38
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
polycystic kidney 2 | 15
abnormal coat-hair pigmentatio... 1 | 64
abnormal colon morphology 1 | 3
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal ileum morphology 1 | 2
abnormal male genitalia morpho... 1 | 3
abnormal tail length 1 | 3
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
decreased urine magnesium leve... 1 | 3
edema 1 | 59
enlarged epididymis 1 | 31
fusion of vertebral arches 1 | 7
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased IgG2b level 1 | 1
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
polysyndactyly 1 | 2
prolonged RR interval 1 | 8
small heart 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small thymus 1 | 16
vertebral transformation 1 | 12

Disease

Carcinoma 198 | 11,192
psoriasis 89 | 6,514
osteosarcoma 81 | 7,766
ovarian cancer 75 | 8,297
medulloblastoma, large-cell 67 | 6,086
glioblastoma 51 | 5,635
Schizophrenia 50 | 1,136
adult high grade glioma 47 | 3,701
Astrocytoma, Pilocytic 46 | 3,006
ependymoma 46 | 4,559
atypical teratoid / rhabdoid tumor 44 | 4,971
lung cancer 42 | 4,607
interstitial cystitis 41 | 2,237
lung adenocarcinoma 37 | 2,627
Bipolar Disorder 35 | 646
malignant mesothelioma 35 | 3,135
Obesity 34 | 655
diabetes mellitus 34 | 1,683
invasive ductal carcinoma 33 | 2,867
lung carcinoma 33 | 2,755
oligodendroglioma 33 | 2,768
Cancer 32 | 2,388
Depressive disorder 32 | 401
group 3 medulloblastoma 31 | 4,002
primitive neuroectodermal tumor 30 | 2,957
non-small cell lung cancer 29 | 2,799
tuberculosis 29 | 1,963
ulcerative colitis 29 | 1,765
Asthma 28 | 370
Mood Disorders 27 | 181
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,902
Alcoholic Intoxication, Chronic 26 | 283
astrocytic glioma 26 | 2,530
Major Depressive Disorder 25 | 293
ductal carcinoma in situ 25 | 1,686
pancreatic cancer 25 | 2,322
Breast cancer 24 | 3,469
Mental Depression 24 | 325
Parkinson's disease 24 | 378
Allergic rhinitis 23 | 93
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,204
cutaneous lupus erythematosus 21 | 1,016
Rheumatoid arthritis 20 | 1,156
colon cancer 20 | 1,428
pituitary cancer 20 | 1,915
Migraine 19 | 78
Nasal congestion 19 | 23
Nasal discharge 19 | 25
Common cold 18 | 66
Hypertension 18 | 372
breast carcinoma 18 | 1,589
Epilepsy 17 | 775
Kidney cancer 17 | 2,548
Multiple Sclerosis 17 | 527
adrenocortical carcinoma 17 | 1,385
Pain 16 | 102
Unipolar Depression 16 | 244
Alcohol dependence 15 | 107
Attention deficit hyperactivity disorder 15 | 272
Pain agnosia 15 | 99
group 4 medulloblastoma 15 | 1,806
primary Sjogren syndrome 15 | 710
Seizures 14 | 584
Substance Withdrawal Syndrome 14 | 53
cystic fibrosis 14 | 1,629
subependymal giant cell astrocytoma 14 | 2,230
Asthma management 13 | 19
Bronchitis 13 | 40
Cerebrovascular disease 13 | 223
Cocaine-Related Disorders 13 | 90
Pulmonary emphysema 13 | 44
Status Epilepticus 13 | 96
astrocytoma 13 | 1,113
hepatocellular carcinoma 13 | 536
Acute exacerbation of asthma 12 | 14
Atopic dermatitis 12 | 915
Autistic Disorder 12 | 358
Hypertensive disorder 12 | 56
Hypotension 12 | 78
Opiate dependence 12 | 29
mucosa-associated lymphoid tissue lymphoma 12 | 473
Alcohol abuse 11 | 48
Alzheimer's disease 11 | 640
General anesthesia 11 | 53
Influenza-like symptoms 11 | 16
Substance abuse 11 | 58
gastric carcinoma 11 | 781
pancreatic carcinoma 11 | 555
Acromegaly 10 | 48
Atherosclerosis 10 | 276
Cocaine Dependence 10 | 51
Coronary artery disease 10 | 253
Fever 10 | 136
Headache disorder 10 | 19
Hyperalgesia 10 | 80
Hypertensive disease 10 | 278
Open-angle glaucoma 10 | 27
Psychotic Disorders 10 | 150
Sinus headache 10 | 16

Tissue

Endocrine System 215 | 18,159
Female tissues 195 | 17,400
Nervous System 191 | 16,725
Digestive Tract 186 | 17,369
Skin and soft tissues 182 | 17,230
Male tissues 179 | 17,142
Blood and immune system 175 | 16,909
Liver and Pancreas 167 | 16,750
Urinary Tract 165 | 16,678
Respiratory system 160 | 16,393
Cardiovascular System 140 | 15,192

Target Family

GPCR 204 | 408
oGPCR 52 | 421
Enzyme 1 | 4,145
Non-IDG 1 | 12,091

WikiPathways Pathway

GPCRs, Class A Rhodopsin-like 258 | 258
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
Olfactory receptor 1D2 OR1D2 Tbio oGPCR -1.01773 10.8 100
Prostaglandin E2 receptor EP1 subtype PTGER1 Tclin GPCR -2.64481 402.0 168
Olfactory receptor 2A4 OR2A4 Tdark oGPCR 0.02 0.85 140
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
Olfactory receptor 2F2 OR2F2 Tdark oGPCR 0.00000 82
Olfactory receptor 2H1 OR2H1 Tdark oGPCR -0.28942 1.98 44
Olfactory receptor 11A1 OR11A1 Tdark oGPCR 0.26 0.38 65
Olfactory receptor 2B2 OR2B2 Tdark oGPCR 0.00000 46