Development Level

Tbio 47 | 10,625
Tchem 19 | 1,890
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 9 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
abnormal lens morphology 2 | 73
cataract 2 | 26
preweaning lethality, incomple... 2 | 260
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased caudal vertebrae num... 1 | 49
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating alkaline... 1 | 119
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
male infertility 1 | 62
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
urinary bladder obstruction 1 | 2

Disease

Cancer 44 | 2,346
ovarian cancer 44 | 8,491
medulloblastoma, large-cell 42 | 6,234
osteosarcoma 41 | 7,933
psoriasis 40 | 6,685
lung cancer 39 | 4,473
glioblastoma 38 | 5,572
malignant mesothelioma 35 | 3,163
primitive neuroectodermal tumor 33 | 3,031
Breast cancer 30 | 3,098
non-small cell lung cancer 28 | 2,798
group 3 medulloblastoma 27 | 2,254
pediatric high grade glioma 26 | 2,712
adrenocortical carcinoma 25 | 1,427
atypical teratoid / rhabdoid tumor 25 | 4,369
pilocytic astrocytoma 21 | 3,086
ductal carcinoma in situ 20 | 1,745
lung adenocarcinoma 20 | 2,714
oligodendroglioma 20 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
invasive ductal carcinoma 18 | 2,950
colon cancer 16 | 1,475
nasopharyngeal carcinoma 16 | 1,056
astrocytoma 15 | 1,493
posterior fossa group A ependymoma 15 | 1,511
atypical teratoid/rhabdoid tumor 14 | 1,095
subependymal giant cell astrocytoma 12 | 2,287
ependymoma 11 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
pancreatic cancer 11 | 2,300
sonic hedgehog group medulloblastoma 11 | 1,482
Endometriosis 10 | 535
Liver carcinoma 10 | 217
Stomach Neoplasms 10 | 282
breast carcinoma 10 | 1,614
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 788
Atopic dermatitis 9 | 944
Mammary Neoplasms 9 | 410
Prostatic Neoplasms 9 | 471
acute quadriplegic myopathy 9 | 1,157
ulcerative colitis 9 | 2,087
Adenoma 8 | 165
Lung Neoplasms 8 | 171
Melanoma 8 | 261
adult high grade glioma 8 | 2,148
dermatomyositis 8 | 966
juvenile dermatomyositis 8 | 1,189
Bladder Neoplasm 7 | 109
Carcinoma 7 | 2,147
Colonic Neoplasms 7 | 126
Multiple myeloma 7 | 1,327
Waldenstrons macroglobulinemia 7 | 764
astrocytic glioma 7 | 2,241
diabetes mellitus 7 | 1,663
Pancreatic Neoplasm 6 | 79
Pick disease 6 | 1,893
Rheumatoid Arthritis 6 | 1,170
Stomach cancer 6 | 18
gastric cancer 6 | 436
group 4 medulloblastoma 6 | 1,875
lung carcinoma 6 | 2,844
medulloblastoma 6 | 1,524
Amyotrophic Lateral Sclerosis 5 | 432
Mammary Neoplasms, Experimental 5 | 149
Meier-Gorlin syndrome 5 | 12
Microcephaly 5 | 149
Papilloma 5 | 27
Seckel syndrome 5 | 35
Squamous cell carcinoma of esophagus 5 | 82
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
chronic lymphocytic leukemia 5 | 244
cystic fibrosis 5 | 1,670
esophageal adenocarcinoma 5 | 737
hepatocellular carcinoma 5 | 550
non-small cell lung carcinoma 5 | 413
ovarian neoplasm 5 | 97
tuberculosis and treatment for 6 months 5 | 686
Adenocarcinoma 4 | 115
Animal Mammary Neoplasms 4 | 135
Duchenne muscular dystrophy 4 | 602
Familial adenomatous polyposis 4 | 33
IGA Glomerulonephritis 4 | 454
Kidney cancer 4 | 121
Liver neoplasms 4 | 108
Multiple Sclerosis 4 | 498
Neoplastic Syndromes, Hereditary 4 | 48
Peripheral Neuropathy 4 | 303
Polycystic Ovary Syndrome 4 | 334
Precursor Cell Lymphoblastic Leukemia Lymphoma 4 | 42
Urinary bladder cancer 4 | 34
Vascular disease 4 | 281
acute myeloid leukemia 4 | 785
cutaneous lupus erythematosus 4 | 1,056
glioblastoma multiforme 4 | 347
pancreatic carcinoma 4 | 567
primary pancreatic ductal adenocarcinoma 4 | 1,271
tuberculosis 4 | 1,563
tuberculosis and treatment for 3 months 4 | 327

Tissue

Endocrine System 69 | 18,511
Blood and immune system 68 | 17,994
Cardiovascular System 68 | 17,957
Digestive Tract 68 | 18,472
Female tissues 68 | 18,646
Liver and Pancreas 68 | 18,135
Male tissues 68 | 17,968
Nervous System 68 | 18,560
Respiratory system 68 | 17,483
Skin and soft tissues 68 | 18,114
Urinary Tract 68 | 18,443

Target Family

Non-IDG 30 | 11,969
Transcription Factor 17 | 1,400
Enzyme 15 | 4,146
Kinase 7 | 634

WikiPathways Pathway

G1 to S cell cycle control 69 | 69
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.67376 362.2 617
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.61943 376.7 290
M-phase inducer phosphatase 1 CDC25A Tchem Enzyme -2.45436 266.0 1243
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.25783 1710.8 1724
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
G1/S-specific cyclin-D2 CCND2 Tchem Non-IDG -2.64611 381.1 418
G1/S-specific cyclin-D3 CCND3 Tchem Non-IDG -2.52581 299.6 513
Wee1-like protein kinase WEE1 Tchem Kinase -2.47729 288.3 429