Development Level

Tbio 50 | 11,651
Tchem 16 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
cataract 2 | 92
edema 2 | 59
increased mean corpuscular vol... 2 | 92
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased caudal vertebrae num... 1 | 53
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

Cancer 45 | 2,499
ovarian cancer 45 | 8,520
group 3 medulloblastoma 43 | 4,104
medulloblastoma, large-cell 42 | 6,241
glioblastoma 41 | 5,792
lung cancer 41 | 4,740
osteosarcoma 41 | 7,950
Carcinoma 40 | 11,493
psoriasis 40 | 6,694
atypical teratoid / rhabdoid tumor 37 | 5,112
malignant mesothelioma 37 | 3,232
Breast cancer 34 | 3,578
primitive neuroectodermal tumor 33 | 3,035
non-small cell lung cancer 28 | 2,890
adult high grade glioma 26 | 3,801
adrenocortical carcinoma 25 | 1,428
ependymoma 23 | 4,679
Astrocytoma, Pilocytic 21 | 3,081
ductal carcinoma in situ 20 | 1,745
lung adenocarcinoma 20 | 2,716
oligodendroglioma 20 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
invasive ductal carcinoma 18 | 2,951
colon cancer 16 | 1,478
nasopharyngeal carcinoma 16 | 1,058
astrocytoma 13 | 1,146
breast carcinoma 12 | 1,638
pancreatic cancer 12 | 2,398
subependymal giant cell astrocytoma 12 | 2,287
Carcinoma, Hepatocellular 11 | 228
Liver carcinoma 11 | 240
Melanoma 11 | 711
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Autosomal recessive predisposition 10 | 1,442
Endometriosis 10 | 540
Prostatic Neoplasms 10 | 495
Stomach Neoplasms 10 | 300
astrocytic glioma 10 | 2,597
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 735
Atopic dermatitis 9 | 952
Breast Neoplasms 9 | 445
Kidney cancer 9 | 2,613
Lung Neoplasms 9 | 232
Mammary Neoplasms 9 | 425
acute quadriplegic myopathy 9 | 1,158
tuberculosis 9 | 2,010
Colonic Neoplasms 8 | 142
dermatomyositis 8 | 966
juvenile dermatomyositis 8 | 1,187
pediatric high grade glioma 8 | 1,064
ulcerative colitis 8 | 1,819
Adenoma 7 | 167
Bladder Neoplasm 7 | 112
Immune system cancer 7 | 140
Lymphoid leukemia 7 | 160
Multiple myeloma 7 | 1,332
Pancreatic Neoplasm 7 | 85
Urinary Bladder Neoplasms 7 | 114
Waldenstrons macroglobulinemia 7 | 765
diabetes mellitus 7 | 1,728
Adenocarcinoma 6 | 122
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Lymphoma 6 | 81
Mesothelioma, Malignant 6 | 105
Pancreatic Neoplasms 6 | 85
Pick disease 6 | 1,894
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Short stature 6 | 531
Small head 6 | 374
Stomach cancer 6 | 30
gastric cancer 6 | 459
lung carcinoma 6 | 2,843
Amyotrophic lateral sclerosis 5 | 451
Chronic Lymphocytic Leukemia 5 | 262
Diarrhea 5 | 253
Esophageal Squamous Cell Carcinoma 5 | 77
Hair shaft abnormalities 5 | 30
Hyperparathyroidism 5 | 48
Liver neoplasms 5 | 130
Mammary Neoplasms, Experimental 5 | 154
Meier-Gorlin syndrome 5 | 10
Microcephaly 5 | 166
Polycystic ovary syndrome 5 | 360
Seckel syndrome 5 | 34
Squamous cell carcinoma 5 | 129
Squamous cell carcinoma of esophagus 5 | 77
Vascular disease 5 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cystic fibrosis 5 | 1,696
esophageal adenocarcinoma 5 | 737
hair abnormalities (non-specific) 5 | 30
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
non-small cell lung carcinoma 5 | 317
ovarian neoplasm 5 | 99

Tissue

Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Endocrine System 68 | 18,159
Female tissues 68 | 17,400
Nervous System 68 | 16,725
Liver and Pancreas 67 | 16,750
Skin and soft tissues 67 | 17,230
Urinary Tract 67 | 16,678
Male tissues 66 | 17,142
Respiratory system 66 | 16,393
Cardiovascular System 64 | 15,192

Target Family

Non-IDG 30 | 12,091
Transcription Factor 17 | 1,400
Enzyme 15 | 4,145
Kinase 7 | 634

WikiPathways Pathway

G1 to S cell cycle control 69 | 69
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.72848 9058.6 1063
Cyclin-dependent kinase 4 inhibitor B CDKN2B Tbio Enzyme -2.61258 428.8 451
Cyclin-dependent kinase 4 inhibitor C CDKN2C Tbio Enzyme -1.97718 112.7 386
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298