Development Level

Tbio 56 | 11,445
Tchem 22 | 1,598
Tclin 12 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
abnormal bone structure 5 | 187
increased startle reflex 5 | 112
abnormal behavior 4 | 298
increased heart weight 4 | 62
preweaning lethality, complete... 4 | 979
decreased vertical activity 3 | 208
hyperactivity 3 | 148
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
short tibia 2 | 97
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal liver size 1 | 5
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
enlarged epididymis 1 | 31
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
small epididymis 1 | 3
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 72 | 11,493
ovarian cancer 60 | 8,520
medulloblastoma, large-cell 59 | 6,241
osteosarcoma 53 | 7,950
glioblastoma 51 | 5,792
atypical teratoid / rhabdoid tumor 50 | 5,112
ependymoma 45 | 4,679
astrocytic glioma 39 | 2,597
primitive neuroectodermal tumor 39 | 3,035
psoriasis 39 | 6,694
group 3 medulloblastoma 37 | 4,104
lung cancer 37 | 4,740
oligodendroglioma 37 | 2,850
adult high grade glioma 34 | 3,801
Astrocytoma, Pilocytic 31 | 3,081
lung carcinoma 30 | 2,843
Kidney cancer 29 | 2,613
Breast cancer 27 | 3,578
lung adenocarcinoma 26 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
Pick disease 23 | 1,894
invasive ductal carcinoma 23 | 2,951
malignant mesothelioma 23 | 3,232
pancreatic cancer 23 | 2,398
subependymal giant cell astrocytoma 23 | 2,287
Cancer 22 | 2,499
ulcerative colitis 22 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
non-small cell lung cancer 20 | 2,890
pituitary cancer 20 | 1,972
colon cancer 19 | 1,478
Depressive disorder 17 | 409
group 4 medulloblastoma 16 | 1,855
tuberculosis 16 | 2,010
Schizophrenia 15 | 1,160
breast carcinoma 14 | 1,638
interstitial cystitis 14 | 2,312
Bipolar Disorder 12 | 666
Rheumatoid arthritis 12 | 1,191
Carney complex 11 | 25
Intellectual disability 11 | 1,016
Mental Depression 11 | 333
Obesity 11 | 678
diabetes mellitus 11 | 1,728
ductal carcinoma in situ 11 | 1,745
Liver cancer 10 | 604
astrocytoma 10 | 1,146
Atrial Fibrillation 9 | 124
Melanoma 9 | 711
Primary pigmented nodular adrenocortical disease 9 | 13
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
pediatric high grade glioma 9 | 1,064
Acrodysostosis 8 | 12
Atopic dermatitis 8 | 952
Autosomal recessive predisposition 8 | 1,442
Chronic heart failure 8 | 46
Crohn's disease 8 | 321
Dull intelligence 8 | 645
Dysuria 8 | 26
Epilepsy 8 | 792
Increased Urinary Frequency 8 | 11
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Myocardial Perfusion Imaging Adjunct 8 | 25
Nocturia 8 | 9
Platelet Aggregation Inhibition 8 | 22
Poor school performance 8 | 645
Prevention of Cerebral Thrombosis 8 | 29
Prostatic Neoplasms 8 | 495
Pseudohypoparathyroidism 8 | 18
Short stature 8 | 531
Substance Withdrawal Syndrome 8 | 55
Suprapubic pain 8 | 8
Urgent desire to urinate 8 | 11
Urinary Incontinence 8 | 50
Urinary Tract Irritation 8 | 24
Waldenstrons macroglobulinemia 8 | 765
acute quadriplegic myopathy 8 | 1,158
cystic fibrosis 8 | 1,696
juvenile dermatomyositis 8 | 1,187
primary pancreatic ductal adenocarcinoma 8 | 1,109
Acquired metabolic disease 7 | 336
Adenoma 7 | 167
Asthma 7 | 385
Cushing's syndrome 7 | 48
Hypertensive disease 7 | 292
McCune Albright syndrome 7 | 19
Multiple myeloma 7 | 1,332
Seizures 7 | 596
Skin cancer 7 | 469
Thyroid cancer 7 | 36
active Crohn's disease 7 | 922
active ulcerative colitis 7 | 764
progressive supranuclear palsy 7 | 676
Chronic obstructive pulmonary disease 6 | 184
Hypertension 6 | 396
aldosterone-producing adenoma 6 | 665
pancreatic carcinoma 6 | 562

Tissue

Endocrine System 90 | 18,159
Blood and immune system 88 | 16,909
Digestive Tract 88 | 17,369
Male tissues 88 | 17,142
Female tissues 87 | 17,400
Nervous System 87 | 16,725
Skin and soft tissues 87 | 17,230
Liver and Pancreas 86 | 16,750
Urinary Tract 86 | 16,678
Cardiovascular System 85 | 15,192
Respiratory system 85 | 16,393

Target Family

Enzyme 44 | 4,145
Non-IDG 32 | 12,091
Kinase 14 | 634
Ion Channel 2 | 344
Epigenetic 1 | 242
Transporter 1 | 473

WikiPathways Pathway

G Protein Signaling Pathways 94 | 94
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
A-kinase anchor protein 11 AKAP11 Tbio Enzyme -1.02415 11.7 38
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.27429 21.3 169
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492