Development Level

Tbio 13 | 11,445
Tchem 9 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
absent startle reflex 1 | 24
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
increased circulating LDL chol... 1 | 13
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
preweaning lethality, incomple... 1 | 499

Disease

Cancer 19 | 2,499
Carcinoma 18 | 11,493
ovarian cancer 17 | 8,520
psoriasis 15 | 6,694
diabetes mellitus 11 | 1,728
group 3 medulloblastoma 11 | 4,104
Schizophrenia 10 | 1,160
lung cancer 10 | 4,740
Obesity 9 | 678
osteosarcoma 9 | 7,950
Breast cancer 8 | 3,578
Vascular disease 8 | 319
Alzheimer's disease 7 | 658
Breast Neoplasms 7 | 445
Intellectual disability 7 | 1,016
Mammary Neoplasms 7 | 425
Stomach Neoplasms 7 | 300
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
Epilepsy 6 | 792
Kidney cancer 6 | 2,613
Renal Cell Carcinoma 6 | 214
ependymoma 6 | 4,679
malignant mesothelioma 6 | 3,232
Arthritis 5 | 290
Autistic Disorder 5 | 364
Carcinoma, Squamous Cell 5 | 110
Depressive disorder 5 | 409
Heart disease 5 | 306
Hyperglycemia 5 | 137
Kidney Neoplasm 5 | 29
Kidney Neoplasms 5 | 37
Kidney disease 5 | 430
Lung Neoplasms 5 | 232
Lymphangioleiomyomatosis 5 | 16
Osteoporosis 5 | 363
Ovarian Neoplasms 5 | 102
Parkinson's disease 5 | 392
Short stature 5 | 531
Squamous cell carcinoma 5 | 129
Toxic encephalopathy 5 | 141
lung adenocarcinoma 5 | 2,716
ovarian neoplasm 5 | 99
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
Asthma 4 | 385
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Cardiomyopathies 4 | 110
Cocaine-Related Disorders 4 | 92
Cognitive delay 4 | 608
Delayed bone age 4 | 136
Dull intelligence 4 | 645
Endometriosis 4 | 540
Female infertility 4 | 30
Global developmental delay 4 | 608
Hypogonadism 4 | 173
Infertility, Female 4 | 28
Inflammation 4 | 120
Leukemia, Myelocytic, Acute 4 | 120
Leukemia, Myeloid, Acute 4 | 105
Low intelligence 4 | 645
Major Depressive Disorder 4 | 301
Male infertility 4 | 206
Mental Depression 4 | 333
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Muscular atrophy 4 | 71
Nerve Degeneration 4 | 121
Pick disease 4 | 1,894
Poor school performance 4 | 645
Substance Withdrawal Syndrome 4 | 55
Unipolar Depression 4 | 250
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung carcinoma 4 | 2,843
tuberculosis 4 | 2,010
Brain Ischemia 3 | 110
Endometrial cancer 3 | 311
Hypertension 3 | 396
Lung disease 3 | 142
Polycystic ovary syndrome 3 | 360
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Cardiovascular System 26 | 15,192
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Nervous System 26 | 16,725
Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Male tissues 25 | 17,142
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Kinase 13 | 634
Non-IDG 9 | 12,091
Enzyme 2 | 4,145
Transcription Factor 2 | 1,400
GPCR 1 | 408

WikiPathways Pathway

Follicle Stimulating Hormone (... 27 | 27
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Glycoprotein hormones alpha chain CGA Tbio Non-IDG -2.62079 405.6 915
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
Brain-derived neurotrophic factor BDNF Tbio Non-IDG -4.00507 10701.6 723
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
DCC-interacting protein 13-alpha APPL1 Tbio Non-IDG -2.75344 511.0 230