Development Level

Tbio 8 | 11,651
Tchem 2 | 1,388

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal retinal vasculature m... 1 | 27
abnormal vocalization 1 | 21
cataract 1 | 92
decreased circulating chloride... 1 | 30
decreased threshold for audito... 1 | 26
increased or absent threshold ... 1 | 101

Disease

Cancer 8 | 2,499
Carcinoma 7 | 11,493
Schizophrenia 6 | 1,160
osteosarcoma 6 | 7,950
ovarian cancer 6 | 8,520
psoriasis 6 | 6,694
Alcoholic Intoxication, Chronic 5 | 289
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
medulloblastoma, large-cell 5 | 6,241
primitive neuroectodermal tumor 5 | 3,035
Alcohol dependence 4 | 107
Bipolar Disorder 4 | 666
Dementia 4 | 175
Depressive disorder 4 | 409
Down syndrome 4 | 499
Epilepsy 4 | 792
Homocystinuria 4 | 21
Hyperhomocysteinemia 4 | 37
Obesity 4 | 678
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
spina bifida 4 | 1,074
Adverse reaction to drug 3 | 61
Alcohol abuse 3 | 50
Alcoholic Intoxication 3 | 34
Atherosclerosis 3 | 291
Autosomal recessive predisposition 3 | 1,442
Brain Ischemia 3 | 110
Breast cancer 3 | 3,578
Drug-Related Side Effects and Adverse Reactions 3 | 62
Lymphoma, Non-Hodgkin 3 | 24
Malnutrition 3 | 11
Mental Depression 3 | 333
Seizures 3 | 596
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Anemia 2 | 365
Astrocytoma, Pilocytic 2 | 3,081
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Cardiovascular Diseases 2 | 59
Cerebrovascular accident 2 | 63
Cerebrovascular disease 2 | 238
Chemical and Drug Induced Liver Injury 2 | 195
Drug Eruptions 2 | 18
Dystonia 2 | 164
Fatty Liver 2 | 70
Female infertility 2 | 30
Frontotemporal dementia 2 | 51
Gastrointestinal Diseases 2 | 12
Hematologic Diseases 2 | 8
Hematological Disease 2 | 18
Hyperhomocystinemia 2 | 6
Hypertension 2 | 396
Infertility, Female 2 | 28
Infertility, Male 2 | 46
Kidney cancer 2 | 2,613
Leukoencephalopathies 2 | 29
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Liver disease 2 | 237
Lung Neoplasms 2 | 232
Lymphoma 2 | 81
Lymphoma, Follicular 2 | 18
Major Depressive Disorder 2 | 301
Male infertility 2 | 206
Mammary Neoplasms 2 | 425
Mood Disorders 2 | 184
Myocardial Infarction 2 | 151
Necrosis 2 | 53
Neural tube defect, folate-sensitive 2 | 4
Neurodegenerative disease 2 | 414
OROFACIAL CLEFT 1 2 | 2
Pick disease 2 | 1,894
Pityriasis versicolor 2 | 19
Prostatic Neoplasms 2 | 495
Pulmonary embolism 2 | 55
Tinea corporis 2 | 25
Unipolar Depression 2 | 250
Vascular disease 2 | 319
Venous Thrombosis 2 | 47
Vitamin B12 deficiency 2 | 20
Voyeurism 2 | 4
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
pituitary cancer 2 | 1,972
tuberculosis 2 | 2,010

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 6 | 4,145
Non-IDG 2 | 12,091
Transcription Factor 2 | 1,400

WikiPathways Pathway

Folate-Alcohol and Cancer Path... 10 | 10
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Cytosolic 10-formyltetrahydrofolate dehydrogenase ALDH1L1 Tbio Enzyme -1.75148 58.8 279
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725
Alcohol dehydrogenase class-3 ADH5 Tchem Enzyme -2.37411 239.5 283
Cystathionine beta-synthase CBS Tbio Enzyme -3.25635 3246.1 391
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Cyclic AMP-responsive element-binding protein 1 CREB1 Tbio Transcription Factor -3.62610 3982.3 1574
Cytochrome P450 2E1 CYP2E1 Tbio Non-IDG -3.41434 2667.8 411