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Development Level

Tbio 34 | 11,651
Tchem 21 | 1,388
Tclin 9 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal heart morphology 5 | 162
enlarged heart 4 | 210
preweaning lethality, incomple... 3 | 499
small testis 3 | 58
abnormal allantois morphology 2 | 8
abnormal embryo size 2 | 220
abnormal neural tube closure 2 | 46
abnormal neural tube morpholog... 2 | 12
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
increased circulating choleste... 2 | 66
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased cardiac muscle contr... 1 | 11
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
tremors 1 | 39

Disease

Cancer 45 | 2,499
psoriasis 39 | 6,694
Carcinoma 37 | 11,493
diabetes mellitus 35 | 1,728
Atherosclerosis 30 | 291
lung cancer 27 | 4,740
ovarian cancer 27 | 8,520
Schizophrenia 26 | 1,160
Hypertension 25 | 396
tuberculosis 25 | 2,010
Autosomal recessive predisposition 24 | 1,442
malignant mesothelioma 24 | 3,232
osteosarcoma 24 | 7,950
glioblastoma 23 | 5,792
Hypertensive disease 22 | 292
Kidney disease 22 | 430
Anemia 21 | 365
Obesity 21 | 678
non-small cell lung cancer 21 | 2,890
Coronary artery disease 20 | 268
Rheumatoid arthritis 20 | 1,191
Brain Ischemia 19 | 110
adult high grade glioma 19 | 3,801
Liver disease 18 | 237
cystic fibrosis 18 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
Breast cancer 17 | 3,578
Cerebrovascular disease 17 | 238
Heart disease 17 | 306
invasive ductal carcinoma 17 | 2,951
pancreatic cancer 17 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Alzheimer's disease 16 | 658
Breast Neoplasms 16 | 445
Chemical and Drug Induced Liver Injury 16 | 195
Mammary Neoplasms 16 | 425
lung carcinoma 16 | 2,843
Asthma 15 | 385
Hyperhomocysteinemia 15 | 37
Lipid metabolism disorder 15 | 114
Myocardial Infarction 15 | 151
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 15 | 4,679
Bipolar Disorder 14 | 666
Diabetes Mellitus, Experimental 14 | 108
Heart failure 14 | 162
Lung disease 14 | 142
Vascular disease 14 | 319
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
medulloblastoma, large-cell 14 | 6,241
ulcerative colitis 14 | 1,819
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
Hyperglycemia 13 | 137
Hypersensitivity reaction type II disease 13 | 253
Major Depressive Disorder 13 | 301
Malaria 13 | 160
colon cancer 13 | 1,478
lung adenocarcinoma 13 | 2,716
Arthritis 12 | 290
Arthritis, Rheumatoid 12 | 174
Astrocytoma, Pilocytic 12 | 3,081
Disease Models, Animal 12 | 155
Fatty Liver 12 | 70
Lung Neoplasms 12 | 232
Pancreatitis 12 | 123
Prostatic Neoplasms 12 | 495
Reperfusion Injury 12 | 86
adrenocortical carcinoma 12 | 1,428
breast carcinoma 12 | 1,638
interstitial cystitis 12 | 2,312
Cerebrovascular accident 11 | 63
Cholestasis 11 | 155
Colonic Neoplasms 11 | 142
Dementia 11 | 175
Depressive disorder 11 | 409
Diabetes Mellitus, Type 2 11 | 142
Hypotension 11 | 82
Inflammatory bowel disease 11 | 151
Kidney Failure, Chronic 11 | 46
Liver Cirrhosis, Experimental 11 | 769
Multiple myeloma 11 | 1,332
Neuropathy 11 | 261
Osteoporosis 11 | 363
Peripheral vascular disease 11 | 87
Seizures 11 | 596
Thrombocytopenia 11 | 197
Unipolar Depression 11 | 250
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
oligodendroglioma 11 | 2,850
periodontitis 11 | 293
sarcoidosis 11 | 370
spina bifida 11 | 1,074
Allergic hypersensitivity disease 10 | 126
Collagen disease 10 | 27
Down syndrome 10 | 499
Endometriosis 10 | 540
Hypereosinophilic syndrome 10 | 71
Mental Depression 10 | 333
Vasculitis 10 | 80

Tissue

Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Liver and Pancreas 64 | 16,750
Skin and soft tissues 64 | 17,230
Female tissues 63 | 17,400
Male tissues 63 | 17,142
Urinary Tract 63 | 16,678
Blood and immune system 61 | 16,909
Nervous System 59 | 16,725
Respiratory system 58 | 16,393
Cardiovascular System 56 | 15,192

Target Family

Enzyme 29 | 4,145
Non-IDG 28 | 12,091
Transcription Factor 4 | 1,400
Transporter 3 | 473
Kinase 1 | 634

WikiPathways Pathway

Folate Metabolism 65 | 65
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
S-adenosylmethionine synthase isoform type-1 MAT1A Tbio Enzyme -2.11527 125.3 167
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
C-reactive protein CRP Tbio Non-IDG -4.57138 36497.6 1389
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Interleukin-1 beta IL1B Tclin Non-IDG -4.40738 24522.4 1588
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298