Development Level
Tbio | 32 | 11,445 | |
Tchem | 22 | 1,598 | |
Tclin | 10 | 613 | |
Tdark | 1 | 6,588 |
IMPC Phenotype
preweaning lethality, complete... | 8 | 979 | |
embryonic lethality prior to o... | 7 | 239 | |
embryonic lethality prior to t... | 6 | 278 | |
abnormal heart morphology | 5 | 162 | |
enlarged heart | 4 | 210 | |
preweaning lethality, incomple... | 3 | 499 | |
small testis | 3 | 58 | |
abnormal allantois morphology | 2 | 8 | |
abnormal embryo size | 2 | 220 | |
abnormal neural tube closure | 2 | 46 | |
abnormal neural tube morpholog... | 2 | 12 | |
abnormal testis morphology | 2 | 43 | |
cataract | 2 | 92 | |
decreased bone mineral content | 2 | 151 | |
decreased circulating amylase ... | 2 | 28 | |
decreased circulating glucose ... | 2 | 126 | |
decreased mean corpuscular vol... | 2 | 79 | |
decreased total body fat amoun... | 2 | 207 | |
decreased vertical activity | 2 | 208 | |
increased circulating choleste... | 2 | 66 | |
abnormal behavior | 1 | 298 | |
abnormal blood vessel morpholo... | 1 | 5 | |
abnormal chorioallantoic fusio... | 1 | 8 | |
abnormal coat appearance | 1 | 31 | |
abnormal cornea morphology | 1 | 31 | |
abnormal embryo turning | 1 | 31 | |
abnormal epididymis morphology | 1 | 42 | |
abnormal forebrain development | 1 | 20 | |
abnormal hindbrain development | 1 | 16 | |
abnormal kidney morphology | 1 | 65 | |
abnormal left-right axis patte... | 1 | 2 | |
abnormal lens morphology | 1 | 81 | |
abnormal limb bud morphology | 1 | 17 | |
abnormal lung morphology | 1 | 26 | |
abnormal midbrain development | 1 | 20 | |
abnormal optic vesicle formati... | 1 | 4 | |
abnormal otic vesicle morpholo... | 1 | 3 | |
abnormal pericardium morpholog... | 1 | 26 | |
abnormal pharyngeal arch morph... | 1 | 8 | |
abnormal retina morphology | 1 | 71 | |
abnormal seminal vesicle morph... | 1 | 114 | |
abnormal skin condition | 1 | 6 | |
abnormal snout morphology | 1 | 23 | |
abnormal somite shape | 1 | 5 | |
abnormal tail bud morphology | 1 | 8 | |
abnormal visceral yolk sac mor... | 1 | 6 | |
abnormal vitelline vasculature... | 1 | 6 | |
cardiovascular system phenotyp... | 1 | 36 | |
decreased cardiac muscle contr... | 1 | 11 | |
decreased circulating fructosa... | 1 | 30 | |
decreased circulating insulin ... | 1 | 76 | |
decreased circulating sodium l... | 1 | 22 | |
decreased circulating triglyce... | 1 | 79 | |
decreased circulating unsatura... | 1 | 2 | |
decreased fasted circulating g... | 1 | 65 | |
decreased heart rate | 1 | 18 | |
decreased lean body mass | 1 | 135 | |
decreased leukocyte cell numbe... | 1 | 73 | |
decreased lymphocyte cell numb... | 1 | 83 | |
decreased mean corpuscular hem... | 1 | 31 | |
decreased thermal nociceptive ... | 1 | 2 | |
embryonic growth retardation | 1 | 106 | |
enlarged epididymis | 1 | 31 | |
enlarged heart atrium | 1 | 4 | |
enlarged spleen | 1 | 41 | |
female infertility | 1 | 60 | |
hydrometra | 1 | 53 | |
hypoactivity | 1 | 132 | |
increased circulating HDL chol... | 1 | 80 | |
increased circulating alkaline... | 1 | 122 | |
increased circulating chloride... | 1 | 41 | |
increased circulating free fat... | 1 | 20 | |
increased circulating iron lev... | 1 | 30 | |
increased erythrocyte cell num... | 1 | 39 | |
increased lean body mass | 1 | 172 | |
increased leukocyte cell numbe... | 1 | 47 | |
increased mean corpuscular vol... | 1 | 92 | |
increased monocyte cell number | 1 | 63 | |
increased neutrophil cell numb... | 1 | 46 | |
increased thermal nociceptive ... | 1 | 9 | |
increased total body fat amoun... | 1 | 134 | |
pale yolk sac | 1 | 25 | |
pallor | 1 | 34 | |
prenatal lethality prior to he... | 1 | 87 | |
prolonged PQ interval | 1 | 5 | |
prolonged QT interval | 1 | 38 | |
tremors | 1 | 39 |
Disease
Tissue
Digestive Tract | 64 | 17,369 | |
Endocrine System | 64 | 18,159 | |
Liver and Pancreas | 64 | 16,750 | |
Skin and soft tissues | 64 | 17,230 | |
Female tissues | 63 | 17,400 | |
Male tissues | 63 | 17,142 | |
Urinary Tract | 63 | 16,678 | |
Blood and immune system | 61 | 16,909 | |
Nervous System | 59 | 16,725 | |
Respiratory system | 58 | 16,393 | |
Cardiovascular System | 56 | 15,192 |
Target Family
Enzyme | 29 | 4,145 | |
Non-IDG | 28 | 12,091 | |
Transcription Factor | 4 | 1,400 | |
Transporter | 3 | 473 | |
Kinase | 1 | 634 |
WikiPathways Pathway
Folate Metabolism | 65 | 65 | |
PI3K-Akt Signaling Pathway | 338 | 338 | |
Focal Adhesion-PI3K-Akt-mTOR-s... | 303 | 303 | |
GPCRs, Class A Rhodopsin-like | 258 | 258 | |
MAPK Signaling Pathway | 245 | 245 | |
VEGFA-VEGFR2 Signaling Pathway | 235 | 235 | |
Focal Adhesion | 206 | 206 | |
Circadian rythm related genes | 200 | 200 | |
Vitamin D Receptor Pathway | 196 | 196 | |
Ras Signaling | 182 | 182 | |
Metapathway biotransformation ... | 172 | 172 | |
Allograft Rejection | 168 | 168 | |
Chemokine signaling pathway | 164 | 164 | |
EGF/EGFR Signaling Pathway | 162 | 162 | |
Insulin Signaling | 160 | 160 | |
EMT transition in Colorectal C... | 159 | 159 | |
Myometrial Relaxation and Cont... | 159 | 159 | |
Sudden Infant Death Syndrome (... | 157 | 157 | |
Calcium Regulation in the Card... | 152 | 152 | |
Integrated Breast Cancer Pathw... | 152 | 152 | |
Regulation of Actin Cytoskelet... | 149 | 149 | |
Mesodermal Commitment Pathway | 147 | 147 | |
Brain-Derived Neurotrophic Fac... | 144 | 144 | |
NRF2 pathway | 143 | 143 | |
Endoderm Differentiation | 141 | 141 | |
Ectoderm Differentiation | 138 | 138 | |
Regulation of toll-like recept... | 138 | 138 | |
Wnt Signaling Pathway | 135 | 135 | |
Angiopoietin Like Protein 8 Re... | 132 | 132 | |
TGF-beta Signaling Pathway | 132 | 132 | |
Adipogenesis | 130 | 130 | |
Proteasome Degradation | 129 | 129 | |
mRNA Processing | 125 | 125 | |
ESC Pluripotency Pathways | 116 | 116 | |
Spinal Cord Injury | 116 | 116 | |
DNA Damage Response (only ATM ... | 112 | 112 | |
Senescence and Autophagy in Ca... | 106 | 106 | |
Cell Cycle | 104 | 104 | |
Electron Transport Chain | 103 | 103 | |
Neural Crest Differentiation | 101 | 101 | |
Toll-like Receptor Signaling P... | 101 | 101 | |
Wnt Signaling Pathway and Plur... | 101 | 101 | |
Integrin-mediated Cell Adhesio... | 100 | 100 | |
B Cell Receptor Signaling Path... | 97 | 97 | |
Corticotropin-releasing hormon... | 95 | 95 | |
G Protein Signaling Pathways | 94 | 94 | |
Amino Acid metabolism | 92 | 92 | |
Apoptosis Modulation and Signa... | 92 | 92 | |
GPCRs, Other | 92 | 92 | |
TNF alpha Signaling Pathway | 92 | 92 | |
T-Cell antigen Receptor (TCR) ... | 90 | 90 | |
Androgen receptor signaling pa... | 89 | 89 | |
Cytoplasmic Ribosomal Proteins | 89 | 89 | |
Retinoblastoma (RB) in Cancer | 87 | 87 | |
Apoptosis | 86 | 86 | |
Selenium Micronutrient Network | 85 | 85 | |
Pyrimidine metabolism | 84 | 84 | |
Signaling Pathways in Glioblas... | 83 | 83 | |
Alzheimers Disease | 82 | 82 | |
MicroRNAs in cardiomyocyte hyp... | 82 | 82 | |
DNA IR-damage and cellular res... | 80 | 80 | |
Notch Signaling Pathway | 79 | 79 | |
Leptin signaling pathway | 76 | 76 | |
Prolactin Signaling Pathway | 76 | 76 | |
Peptide GPCRs | 75 | 75 | |
Arrhythmogenic Right Ventricul... | 74 | 74 | |
Chromosomal and microsatellite... | 74 | 74 | |
miRNA Regulation of DNA Damage... | 73 | 73 | |
Primary Focal Segmental Glomer... | 72 | 72 | |
Type II interferon signaling (... | 71 | 71 | |
DNA Damage Response | 69 | 69 | |
G1 to S cell cycle control | 69 | 69 | |
Parkin-Ubiquitin Proteasomal S... | 69 | 69 | |
Sterol Regulatory Element-Bind... | 69 | 69 | |
AMP-activated Protein Kinase (... | 68 | 68 | |
Human Thyroid Stimulating Horm... | 68 | 68 | |
PPAR signaling pathway | 67 | 67 | |
Rac1/Pak1/p38/MMP-2 pathway | 67 | 67 | |
AGE/RAGE pathway | 66 | 66 | |
Association Between Physico-Ch... | 66 | 66 | |
Oncostatin M Signaling Pathway | 65 | 65 | |
Lung fibrosis | 64 | 64 | |
Pathways Affected in Adenoid C... | 64 | 64 | |
Endometrial cancer | 63 | 63 | |
Endochondral Ossification | 62 | 62 | |
MECP2 and Associated Rett Synd... | 62 | 62 | |
Oxidation by Cytochrome P450 | 62 | 62 | |
TYROBP Causal Network | 61 | 61 | |
Oxidative phosphorylation | 60 | 60 | |
T-Cell antigen Receptor (TCR) ... | 60 | 60 | |
Complement and Coagulation Cas... | 59 | 59 | |
Kit receptor signaling pathway | 59 | 59 | |
RIG-I-like Receptor Signaling | 59 | 59 | |
Preimplantation Embryo | 58 | 58 | |
DNA IR-Double Strand Breaks (D... | 56 | 56 | |
IL-1 signaling pathway | 55 | 55 | |
MET in type 1 papillary renal ... | 55 | 55 | |
RANKL/RANK (Receptor activator... | 55 | 55 | |
Pathogenic Escherichia coli in... | 54 | 54 | |
TGF-beta Receptor Signaling | 54 | 54 |
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