Development Level

Tbio 30 | 10,625
Tchem 25 | 1,890
Tclin 9 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
abnormal heart morphology 2 | 51
abnormal retina morphology 2 | 100
abnormal testis morphology 2 | 30
decreased circulating amylase ... 2 | 24
decreased circulating glucose ... 2 | 121
preweaning lethality, incomple... 2 | 260
small testis 2 | 37
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal kidney morphology 1 | 30
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 18
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased cardiac muscle contr... 1 | 5
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased heart rate 1 | 10
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
enlarged epididymis 1 | 27
enlarged heart atrium 1 | 2
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased exploration in new e... 1 | 56
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64
tremors 1 | 34

Disease

Cancer 43 | 2,346
psoriasis 39 | 6,685
diabetes mellitus 34 | 1,663
Atherosclerosis 28 | 275
lung cancer 26 | 4,473
ovarian cancer 26 | 8,492
osteosarcoma 24 | 7,933
tuberculosis 23 | 1,563
Kidney disease 22 | 397
glioblastoma 22 | 5,572
malignant mesothelioma 21 | 3,163
non-small cell lung cancer 21 | 2,798
Coronary artery disease 20 | 240
Hypertension 20 | 293
Obesity 19 | 616
Rheumatoid Arthritis 19 | 1,171
Anemia 18 | 252
Heart disease 18 | 279
Hypertensive disease 18 | 193
cystic fibrosis 18 | 1,670
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
Brain Ischemia 17 | 87
Cerebrovascular disease 17 | 231
invasive ductal carcinoma 17 | 2,950
ulcerative colitis 17 | 2,087
Alzheimer's disease 16 | 644
Liver disease 16 | 219
Mammary Neoplasms 16 | 410
lung carcinoma 16 | 2,844
pancreatic cancer 16 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Breast cancer 15 | 3,099
Drug-Induced Liver Injury 15 | 118
Asthma 14 | 349
Diabetes Mellitus, Experimental 14 | 106
Heart failure 14 | 80
Hyperhomocysteinemia 14 | 34
Lung disease 14 | 136
Vascular disease 14 | 281
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
medulloblastoma, large-cell 14 | 6,234
pediatric high grade glioma 14 | 2,712
Diabetes Mellitus, Non-Insulin-Dependent 13 | 161
Hyperglycemia 13 | 120
Hypersensitivity reaction type II disease 13 | 235
Lipid metabolism disorder 13 | 102
Metabolic syndrome X 13 | 155
colon cancer 13 | 1,475
lung adenocarcinoma 13 | 2,714
Lung Neoplasms 12 | 171
Malaria 12 | 140
Peripheral Neuropathy 12 | 303
Prostatic Neoplasms 12 | 471
Reperfusion Injury 12 | 84
adrenocortical carcinoma 12 | 1,427
interstitial cystitis 12 | 2,299
pilocytic astrocytoma 12 | 3,086
Arthritis 11 | 248
Colonic Neoplasms 11 | 126
Dementia 11 | 129
Inflammatory bowel disease 11 | 142
Kidney Failure, Chronic 11 | 45
Multiple myeloma 11 | 1,328
Peripheral vascular disease 11 | 90
atypical teratoid / rhabdoid tumor 11 | 4,369
breast carcinoma 11 | 1,614
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
oligodendroglioma 11 | 2,849
Allergic hypersensitivity disease 10 | 123
Amyloidosis 10 | 68
Arthritis, Experimental 10 | 39
Autistic Disorder 10 | 320
Cardiovascular Diseases 10 | 50
Cerebrovascular accident 10 | 44
Diarrhea 10 | 155
Down syndrome 10 | 548
Endometriosis 10 | 535
Fatty Liver 10 | 48
Fatty liver disease 10 | 86
Hypotension 10 | 53
Inflammation 10 | 109
Leukopenia 10 | 42
Osteoporosis 10 | 259
Pancreatitis 10 | 97
Peritonitis 10 | 37
Schizophrenia 10 | 503
Thrombocytopenia 10 | 105
Vasculitis 10 | 64
periodontitis 10 | 269
posterior fossa group A ependymoma 10 | 1,511
primary pancreatic ductal adenocarcinoma 10 | 1,271
sarcoidosis 10 | 368
Collagen disease 9 | 25
Dermatitis 9 | 141
Multiple Sclerosis 9 | 498
Neuropathy 9 | 210
Polycystic Ovary Syndrome 9 | 335
Stomach Neoplasms 9 | 282
astrocytoma 9 | 1,493

Tissue

Blood and immune system 65 | 17,995
Cardiovascular System 65 | 17,958
Digestive Tract 65 | 18,473
Female tissues 65 | 18,647
Male tissues 65 | 17,969
Nervous System 65 | 18,561
Endocrine System 64 | 18,512
Liver and Pancreas 64 | 18,136
Skin and soft tissues 64 | 18,115
Urinary Tract 64 | 18,444
Respiratory system 62 | 17,484

Target Family

Enzyme 29 | 4,146
Non-IDG 28 | 11,969
Transcription Factor 4 | 1,400
Transporter 3 | 473
Kinase 1 | 634

WikiPathways Pathway

Folate Metabolism 65 | 65
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
S-adenosylmethionine synthase isoform type-1 MAT1A Tbio Enzyme -2.10045 120.8 147
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.19727 163.1 71
Folate transporter 1 SLC19A1 Tchem Transporter -1.98678 92.5 52
Folate receptor gamma FOLR3 Tbio Non-IDG -0.78692 5.68 76
Methionine synthase MTR Tbio Enzyme -2.55992 290.0 77
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Folate receptor alpha FOLR1 Tchem Non-IDG -2.27944 181.4 235
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.66762 4846.8 245
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.90915 869.1 327
Alpha-1-antichymotrypsin SERPINA3 Tchem Non-IDG -2.94207 803.8 261