Development Level

Tbio 153 | 10,625
Tchem 92 | 1,890
Tclin 49 | 602
Tdark 9 | 7,003

Collection

Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 13 | 633
enlarged heart 8 | 111
embryonic lethality prior to t... 6 | 187
preweaning lethality, incomple... 6 | 260
abnormal embryo size 5 | 112
decreased lean body mass 5 | 195
increased mean corpuscular hem... 5 | 93
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased circulating glucose ... 4 | 121
decreased total body fat amoun... 4 | 186
thrombocytopenia 4 | 46
abnormal bone structure 3 | 131
abnormal forebrain development 3 | 18
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal neural tube closure 3 | 37
decreased body length 3 | 108
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased grip strength 3 | 123
embryonic lethality prior to o... 3 | 148
enlarged spleen 3 | 26
increased circulating alkaline... 3 | 119
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
abnormal behavior 2 | 226
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal sleep behavior 2 | 63
abnormal vocalization 2 | 21
cataract 2 | 26
corneal opacity 2 | 25
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased hemoglobin content 2 | 53
decreased kidney weight 2 | 7
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
enlarged epididymis 2 | 27
enlarged lymph nodes 2 | 27
female infertility 2 | 34
hydrometra 2 | 13
impaired pupillary reflex 2 | 14
increased bone mineral content 2 | 92
increased circulating LDL chol... 2 | 15
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased neutrophil cell numb... 2 | 15
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
small superior vagus ganglion 2 | 20
small testis 2 | 37
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal heart left ventricle ... 1 | 20
abnormal lung morphology 1 | 15
abnormal respiratory quotient 1 | 9
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating potassiu... 1 | 17
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
dilated heart left ventricle 1 | 10
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased grip strength 1 | 83
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
thin ventricular wall 1 | 5
thrombocytosis 1 | 23

Disease

ovarian cancer 175 | 8,484
osteosarcoma 162 | 7,933
Cancer 158 | 2,346
psoriasis 152 | 6,685
medulloblastoma, large-cell 134 | 6,234
glioblastoma 130 | 5,572
lung cancer 121 | 4,466
Breast cancer 100 | 3,094
atypical teratoid / rhabdoid tumor 99 | 4,369
Carcinoma 94 | 2,147
malignant mesothelioma 91 | 3,162
invasive ductal carcinoma 89 | 2,950
lung adenocarcinoma 82 | 2,713
lung carcinoma 82 | 2,844
pilocytic astrocytoma 82 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,956
non-small cell lung cancer 79 | 2,798
interstitial cystitis 76 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,289
pancreatic cancer 74 | 2,300
ulcerative colitis 71 | 2,087
diabetes mellitus 69 | 1,663
oligodendroglioma 67 | 2,849
pediatric high grade glioma 67 | 2,712
subependymal giant cell astrocytoma 65 | 2,287
breast carcinoma 60 | 1,614
ependymoma 60 | 2,514
ductal carcinoma in situ 56 | 1,745
pituitary cancer 56 | 1,972
primitive neuroectodermal tumor 56 | 3,031
cystic fibrosis 53 | 1,665
primary pancreatic ductal adenocarcinoma 51 | 1,271
group 3 medulloblastoma 49 | 2,254
Mammary Neoplasms 44 | 410
astrocytoma 43 | 1,493
adrenocortical carcinoma 42 | 1,427
adult high grade glioma 42 | 2,148
group 4 medulloblastoma 42 | 1,875
astrocytic glioma 41 | 2,241
tuberculosis 41 | 1,557
colon cancer 40 | 1,475
gastric carcinoma 38 | 832
juvenile dermatomyositis 38 | 1,189
posterior fossa group A ependymoma 37 | 1,511
Obesity 36 | 616
Rheumatoid Arthritis 35 | 1,160
non-small cell lung carcinoma 35 | 413
Prostatic Neoplasms 34 | 471
Pick disease 33 | 1,893
acute quadriplegic myopathy 33 | 1,157
sonic hedgehog group medulloblastoma 33 | 1,482
Duchenne muscular dystrophy 31 | 602
nasopharyngeal carcinoma 31 | 1,056
Vascular disease 30 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
cutaneous lupus erythematosus 30 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,795
Multiple myeloma 27 | 1,327
dermatomyositis 27 | 933
Schizophrenia 26 | 501
medulloblastoma 25 | 1,524
primary Sjogren syndrome 25 | 789
Renal Cell Carcinoma 24 | 199
Atopic dermatitis 23 | 944
Kidney disease 23 | 396
Liver carcinoma 23 | 217
Neoplasm Metastasis 23 | 138
esophageal adenocarcinoma 23 | 737
Heart disease 22 | 279
spina bifida 22 | 1,064
Alzheimer's disease 21 | 644
Atherosclerosis 21 | 275
Lung Neoplasms 21 | 171
Autistic Disorder 20 | 320
Hyperglycemia 20 | 120
Multiple Sclerosis 20 | 498
Arthritis 19 | 248
Coronary artery disease 19 | 240
Stomach Neoplasms 19 | 282
fibroadenoma 19 | 557
pancreatic carcinoma 19 | 567
Cerebrovascular disease 18 | 231
Down syndrome 18 | 548
Endometriosis 18 | 535
Intellectual disability 18 | 573
Parkinson's disease 18 | 364
atypical teratoid/rhabdoid tumor 18 | 1,095
interstitial lung disease 18 | 291
posterior fossa group B ependymoma 18 | 1,530
Asthma 17 | 349
Hypertension 17 | 287
Neoplasm Invasiveness 17 | 127
Squamous cell carcinoma 17 | 94
Waldenstrons macroglobulinemia 17 | 765
active Crohn's disease 17 | 918
urothelial carcinoma 17 | 318
Becker muscular dystrophy 16 | 187
Hypertensive disease 16 | 193
Spontaneous abortion 16 | 108

Tissue

Nervous System 303 | 18,561
Digestive Tract 302 | 18,473
Endocrine System 302 | 18,512
Female tissues 302 | 18,647
Urinary Tract 300 | 18,444
Liver and Pancreas 299 | 18,136
Blood and immune system 298 | 17,995
Skin and soft tissues 298 | 18,115
Cardiovascular System 296 | 17,958
Male tissues 293 | 17,969
Respiratory system 290 | 17,484

Target Family

Non-IDG 179 | 11,971
Kinase 53 | 634
Enzyme 42 | 4,146
Transcription Factor 16 | 1,400
GPCR 9 | 406
Transporter 4 | 473

WikiPathways Pathway

Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Laminin subunit alpha-2 LAMA2 Tbio Non-IDG -2.48634 321.9 131
Tenascin-N TNN Tbio Non-IDG -1.77329 68.8 63
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549