Development Level

Tbio 183 | 11,651
Tchem 62 | 1,388
Tclin 51 | 612
Tdark 7 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 11 | 499
enlarged heart 9 | 210
embryonic lethality prior to t... 7 | 278
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal behavior 4 | 298
abnormal heart morphology 4 | 162
cataract 4 | 92
decreased body weight 4 | 161
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
enlarged spleen 4 | 41
increased mean corpuscular hem... 4 | 96
increased mean corpuscular vol... 4 | 92
male infertility 4 | 123
thrombocytopenia 4 | 56
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
enlarged lymph nodes 3 | 37
hypoactivity 3 | 132
impaired pupillary reflex 3 | 26
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased heart weight 3 | 62
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal cornea morphology 2 | 31
abnormal gait 2 | 69
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
female infertility 2 | 60
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 36
increased startle reflex 2 | 112
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased mean corpuscular hem... 1 | 31
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
iris synechia 1 | 3
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 223 | 11,493
ovarian cancer 176 | 8,520
Cancer 162 | 2,499
osteosarcoma 162 | 7,950
psoriasis 152 | 6,694
glioblastoma 144 | 5,792
medulloblastoma, large-cell 134 | 6,241
lung cancer 129 | 4,740
Breast cancer 121 | 3,578
atypical teratoid / rhabdoid tumor 111 | 5,112
malignant mesothelioma 100 | 3,232
ependymoma 98 | 4,679
Kidney cancer 89 | 2,613
invasive ductal carcinoma 89 | 2,951
non-small cell lung cancer 85 | 2,890
adult high grade glioma 84 | 3,801
lung adenocarcinoma 82 | 2,716
lung carcinoma 82 | 2,843
group 3 medulloblastoma 81 | 4,104
Astrocytoma, Pilocytic 79 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,955
pancreatic cancer 77 | 2,398
interstitial cystitis 76 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,291
diabetes mellitus 71 | 1,728
oligodendroglioma 67 | 2,850
breast carcinoma 66 | 1,638
subependymal giant cell astrocytoma 65 | 2,287
ulcerative colitis 62 | 1,819
Autosomal recessive predisposition 57 | 1,442
ductal carcinoma in situ 56 | 1,745
pituitary cancer 56 | 1,972
primitive neuroectodermal tumor 56 | 3,035
astrocytic glioma 54 | 2,597
cystic fibrosis 53 | 1,696
Schizophrenia 48 | 1,160
tuberculosis 48 | 2,010
Breast Neoplasms 46 | 445
Mammary Neoplasms 46 | 425
group 4 medulloblastoma 43 | 1,855
adrenocortical carcinoma 42 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,962
colon cancer 40 | 1,478
Liver Cirrhosis, Experimental 39 | 769
Obesity 39 | 678
Melanoma 38 | 711
juvenile dermatomyositis 38 | 1,187
Rheumatoid arthritis 37 | 1,191
primary pancreatic ductal adenocarcinoma 37 | 1,109
Seizures 36 | 596
gastric carcinoma 36 | 807
Epilepsy 35 | 792
Prostatic Neoplasms 35 | 495
astrocytoma 34 | 1,146
Pick disease 33 | 1,894
acute quadriplegic myopathy 33 | 1,158
Depressive disorder 32 | 409
Vascular disease 32 | 319
Duchenne muscular dystrophy 31 | 601
Intellectual disability 31 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 510
cutaneous lupus erythematosus 30 | 1,057
nasopharyngeal carcinoma 30 | 1,058
Hypertension 28 | 396
Renal Cell Carcinoma 28 | 214
Short stature 28 | 531
Orbital separation excessive 27 | 244
Skin cancer 27 | 469
dermatomyositis 27 | 966
Bipolar Disorder 26 | 666
Cognitive delay 26 | 608
Dull intelligence 26 | 645
Global developmental delay 26 | 608
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental and motor retardation 26 | 608
Mental deficiency 26 | 645
Multiple myeloma 26 | 1,332
Poor school performance 26 | 645
Neoplasm Metastasis 25 | 168
non-small cell lung carcinoma 25 | 317
pediatric high grade glioma 25 | 1,064
Carcinoma, Hepatocellular 24 | 228
Hyperglycemia 24 | 137
Kidney disease 24 | 430
Liver cancer 24 | 604
Liver carcinoma 24 | 240
Mental Depression 24 | 333
Stomach Neoplasms 24 | 300
Alzheimer's disease 23 | 658
Anemia 23 | 365
Atherosclerosis 23 | 291
Atopic dermatitis 23 | 952
esophageal adenocarcinoma 23 | 737
Hypoplastic mandible condyle 22 | 275
Mandibular hypoplasia 22 | 275
Micrognathism 22 | 275
Multiple Sclerosis 22 | 540
spina bifida 22 | 1,074

Tissue

Endocrine System 298 | 18,159
Digestive Tract 297 | 17,369
Female tissues 294 | 17,400
Skin and soft tissues 294 | 17,230
Liver and Pancreas 292 | 16,750
Blood and immune system 290 | 16,909
Male tissues 288 | 17,142
Nervous System 288 | 16,725
Urinary Tract 288 | 16,678
Respiratory system 283 | 16,393
Cardiovascular System 271 | 15,192

Target Family

Non-IDG 179 | 12,091
Kinase 53 | 634
Enzyme 42 | 4,145
Transcription Factor 16 | 1,400
GPCR 9 | 408
Transporter 4 | 473

WikiPathways Pathway

Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
PI3K-Akt Signaling Pathway 338 | 338
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
T-cell leukemia/lymphoma protein 1B TCL1B Tdark Non-IDG -1.17863 16.3 34
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Integrin beta-7 ITGB7 Tclin Non-IDG -1.63572 38.4 374