Development Level

Tbio 117 | 11,445
Tchem 58 | 1,598
Tclin 29 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 7 | 499
decreased circulating choleste... 4 | 93
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal bone mineralization 3 | 38
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
decreased neutrophil cell numb... 3 | 42
increased bone mineral density 3 | 72
increased circulating triglyce... 3 | 42
abnormal femur morphology 2 | 14
abnormal skin morphology 2 | 50
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased leukocyte cell numbe... 2 | 73
decreased vertical activity 2 | 208
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
absent testes 1 | 6
cataract 1 | 92
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
mammalian phenotype 1 | 17
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 170 | 11,493
ovarian cancer 132 | 8,520
glioblastoma 113 | 5,792
osteosarcoma 113 | 7,950
Cancer 111 | 2,499
psoriasis 94 | 6,694
lung cancer 90 | 4,740
Breast cancer 89 | 3,578
medulloblastoma, large-cell 89 | 6,241
atypical teratoid / rhabdoid tumor 82 | 5,112
Kidney cancer 80 | 2,613
invasive ductal carcinoma 75 | 2,951
ependymoma 72 | 4,679
pancreatic cancer 72 | 2,398
malignant mesothelioma 68 | 3,232
Astrocytoma, Pilocytic 66 | 3,081
adult high grade glioma 65 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 64 | 2,989
non-small cell lung cancer 63 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,291
lung carcinoma 61 | 2,843
interstitial cystitis 56 | 2,312
lung adenocarcinoma 56 | 2,716
oligodendroglioma 54 | 2,850
cystic fibrosis 51 | 1,696
group 3 medulloblastoma 50 | 4,104
primitive neuroectodermal tumor 49 | 3,035
breast carcinoma 43 | 1,638
tuberculosis 43 | 2,010
Autosomal recessive predisposition 42 | 1,442
diabetes mellitus 42 | 1,728
subependymal giant cell astrocytoma 42 | 2,287
colon cancer 41 | 1,478
ulcerative colitis 41 | 1,819
ductal carcinoma in situ 40 | 1,745
Schizophrenia 38 | 1,160
group 4 medulloblastoma 38 | 1,855
astrocytic glioma 36 | 2,597
juvenile dermatomyositis 36 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
pituitary cancer 36 | 1,972
Liver Cirrhosis, Experimental 34 | 769
primary pancreatic ductal adenocarcinoma 34 | 1,109
Breast Neoplasms 31 | 445
gastric carcinoma 31 | 807
Duchenne muscular dystrophy 30 | 601
Mammary Neoplasms 30 | 425
Melanoma 30 | 711
adrenocortical carcinoma 29 | 1,428
Intellectual disability 28 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Liver cancer 27 | 604
Short stature 27 | 531
astrocytoma 27 | 1,146
Kidney disease 26 | 430
Skin cancer 26 | 469
acute quadriplegic myopathy 26 | 1,158
nasopharyngeal carcinoma 26 | 1,058
Epilepsy 24 | 792
Pick disease 24 | 1,894
Prostatic Neoplasms 24 | 495
Vascular disease 24 | 319
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Rheumatoid arthritis 23 | 1,191
spina bifida 23 | 1,074
Acquired scoliosis 22 | 281
Curvature of spine 22 | 282
Heart disease 22 | 306
Hypertension 22 | 396
Muscle hypotonia 21 | 571
Neoplasm Invasiveness 21 | 161
Neoplasm Metastasis 21 | 168
Orbital separation excessive 21 | 244
Seizures 21 | 596
Stomach Neoplasms 21 | 300
dermatomyositis 21 | 966
pediatric high grade glioma 21 | 1,064
Myopia 20 | 176
Renal Cell Carcinoma 20 | 214
cutaneous lupus erythematosus 20 | 1,057
interstitial lung disease 20 | 298
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Hypoplastic mandible condyle 19 | 275
Mandibular hypoplasia 19 | 275
Mental and motor retardation 19 | 608
Micrognathism 19 | 275
esophageal adenocarcinoma 19 | 737
Alzheimer's disease 18 | 658
Pectus excavatum 18 | 100
Becker muscular dystrophy 17 | 191
Lung Neoplasms 17 | 232
Multiple myeloma 17 | 1,332
fibroadenoma 17 | 559
urothelial carcinoma 17 | 318

Tissue

Digestive Tract 205 | 17,369
Endocrine System 205 | 18,159
Female tissues 205 | 17,400
Liver and Pancreas 205 | 16,750
Skin and soft tissues 205 | 17,230
Blood and immune system 204 | 16,909
Male tissues 204 | 17,142
Nervous System 201 | 16,725
Urinary Tract 201 | 16,678
Respiratory system 199 | 16,393
Cardiovascular System 194 | 15,192

Target Family

Non-IDG 128 | 12,091
Kinase 54 | 634
Enzyme 21 | 4,145
Transcription Factor 3 | 1,400

WikiPathways Pathway

Focal Adhesion 206 | 206
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Myosin regulatory light chain 2, atrial isoform MYL7 Tbio Non-IDG -0.85198 5.20 169
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Collagen alpha-1(XI) chain COL11A1 Tbio Non-IDG -2.15516 138.4 96
Collagen alpha-2(VI) chain COL6A2 Tbio Non-IDG -1.80531 59.2 151