Development Level

Tbio 12 | 11,445
Tchem 12 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal sleep behavior 1 | 70
abnormal stomach morphology 1 | 10
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
limb grasping 1 | 41
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 25 | 11,493
Cancer 22 | 2,499
lung cancer 19 | 4,740
medulloblastoma, large-cell 19 | 6,241
psoriasis 18 | 6,694
Colorectal Neoplasms 17 | 243
osteosarcoma 17 | 7,950
ovarian cancer 17 | 8,520
glioblastoma 16 | 5,792
atypical teratoid / rhabdoid tumor 13 | 5,112
ependymoma 13 | 4,679
non-small cell lung cancer 13 | 2,890
group 3 medulloblastoma 12 | 4,104
adrenocortical carcinoma 11 | 1,428
adult high grade glioma 11 | 3,801
malignant mesothelioma 11 | 3,232
primitive neuroectodermal tumor 11 | 3,035
tuberculosis 11 | 2,010
Breast cancer 10 | 3,578
Astrocytoma, Pilocytic 9 | 3,081
Autosomal recessive predisposition 9 | 1,442
Breast Neoplasms 9 | 445
Endometriosis 9 | 540
Mammary Neoplasms 9 | 425
Rheumatoid arthritis 9 | 1,191
Stomach Neoplasms 9 | 300
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Arthritis, Rheumatoid 8 | 174
Prostatic Neoplasms 8 | 495
interstitial cystitis 8 | 2,312
invasive ductal carcinoma 8 | 2,951
lung adenocarcinoma 8 | 2,716
ulcerative colitis 8 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Adverse reaction to drug 6 | 61
Carcinoma, Hepatocellular 6 | 228
Colonic Neoplasms 6 | 142
Disease Models, Animal 6 | 155
Drug-Related Side Effects and Adverse Reactions 6 | 62
Epilepsy 6 | 792
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Neoplasm Metastasis 6 | 168
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung carcinoma 6 | 2,843
Adenocarcinoma of lung 5 | 142
Bladder Neoplasm 5 | 112
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Kidney cancer 5 | 2,613
Mental and motor retardation 5 | 608
Nervous System Diseases 5 | 53
Pancreatic Neoplasm 5 | 85
Pancreatic Neoplasms 5 | 85
Seizures 5 | 596
Urinary Bladder Neoplasms 5 | 114
Xeroderma pigmentosum group D 5 | 33
active Crohn's disease 5 | 922
breast carcinoma 5 | 1,638
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
nervous system disorder 5 | 53
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
Acute lymphoid leukemia 4 | 25
Alcoholic Intoxication, Chronic 4 | 289
Anemia 4 | 365
Atopic dermatitis 4 | 952
Autistic Disorder 4 | 364
Carcinoma, Squamous Cell 4 | 110
Chemical and Drug Induced Liver Injury 4 | 195
Liver Cirrhosis, Experimental 4 | 769
Melanoma 4 | 711
Squamous cell carcinoma 4 | 129
atypical teratoid/rhabdoid tumor 4 | 357
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung carcinoma 4 | 317
Adenoma 3 | 167
Alzheimer's disease 3 | 658
Atrial Fibrillation 3 | 124
Cerebral atrophy 3 | 178
Cockayne syndrome 3 | 60
Pick disease 3 | 1,894
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 | 49
Schizophrenia 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 665
chronic rhinosinusitis 3 | 512
cystic fibrosis and chronic rhinosinusitis 3 | 214
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 547
mucosa-associated lymphoid tissue lymphoma 3 | 484
nephrosclerosis 3 | 333
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Endocrine System 33 | 18,159
Liver and Pancreas 33 | 16,750
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 31 | 16,393
Cardiovascular System 30 | 15,192

Target Family

Enzyme 21 | 4,145
Transporter 6 | 473
Kinase 3 | 634
Non-IDG 2 | 12,091
Transcription Factor 1 | 1,400

WikiPathways Pathway

Fluoropyrimidine Activity 33 | 33
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Thymidine phosphorylase TYMP Tclin Enzyme -2.83170 677.8 514
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.61544 427.2 413
Ribonucleoside-diphosphate reductase large subunit RRM1 Tclin Enzyme -2.84926 663.0 399
Multidrug resistance-associated protein 4 ABCC4 Tchem Transporter -2.56001 341.6 352
Thymidine kinase, cytosolic TK1 Tchem Kinase -2.56213 363.6 281
Cocaine esterase CES2 Tchem Enzyme -2.43360 271.1 276
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275