Development Level

Tchem 20 | 1,598
Tbio 19 | 11,445
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone structure 3 | 187
embryonic lethality prior to t... 3 | 278
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
embryonic growth retardation 2 | 106
preweaning lethality, incomple... 2 | 499
abnormal clavicle morphology 1 | 6
abnormal embryo size 1 | 220
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal startle reflex 1 | 15
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased mean corpuscular hem... 1 | 96
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74

Disease

Cancer 29 | 2,499
Carcinoma 29 | 11,493
glioblastoma 27 | 5,792
lung cancer 25 | 4,740
osteosarcoma 25 | 7,950
ovarian cancer 24 | 8,520
psoriasis 23 | 6,694
medulloblastoma, large-cell 19 | 6,241
ependymoma 17 | 4,679
atypical teratoid / rhabdoid tumor 16 | 5,112
Breast cancer 15 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
malignant mesothelioma 15 | 3,232
Astrocytoma, Pilocytic 14 | 3,081
group 3 medulloblastoma 12 | 4,104
lung carcinoma 12 | 2,843
Alzheimer's disease 11 | 658
non-small cell lung cancer 11 | 2,890
tuberculosis 11 | 2,010
Mammary Neoplasms 10 | 425
Rheumatoid arthritis 10 | 1,191
adult high grade glioma 10 | 3,801
diabetes mellitus 10 | 1,728
group 4 medulloblastoma 10 | 1,855
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
Breast Neoplasms 9 | 445
Kidney cancer 9 | 2,613
Schizophrenia 9 | 1,160
Vascular disease 9 | 319
colon cancer 9 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
subependymal giant cell astrocytoma 9 | 2,287
Brain Ischemia 8 | 110
Lung Neoplasms 8 | 232
Parkinson's disease 8 | 392
Reperfusion Injury 8 | 86
Toxic encephalopathy 8 | 141
dermatomyositis 8 | 966
lung adenocarcinoma 8 | 2,716
ulcerative colitis 8 | 1,819
Asthma 7 | 385
Eye disease 7 | 62
Hypersensitivity reaction type II disease 7 | 253
Kidney disease 7 | 430
Obesity 7 | 678
Pick disease 7 | 1,894
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
oligodendroglioma 7 | 2,850
Arthritis 6 | 290
Autosomal recessive predisposition 6 | 1,442
Brain disease 6 | 96
Carcinoma, Hepatocellular 6 | 228
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Inflammatory bowel disease 6 | 151
Intellectual disability 6 | 1,016
Liver carcinoma 6 | 240
Liver disease 6 | 237
Lung disease 6 | 142
Prostatic Neoplasms 6 | 495
Short stature 6 | 531
Stomach Neoplasms 6 | 300
astrocytic glioma 6 | 2,597
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
hepatocellular carcinoma 6 | 547
juvenile dermatomyositis 6 | 1,187
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Atherosclerosis 5 | 291
Autoimmune lymphoproliferative syndrome 5 | 11
Bipolar Disorder 5 | 666
Cardiomyopathies 5 | 110
Cerebrovascular disease 5 | 238
Craniofacial Abnormalities 5 | 151
Depressive disorder 5 | 409
Diabetes Mellitus, Type 2 5 | 142
Endometriosis 5 | 540
Heart disease 5 | 306
Hyperglycemia 5 | 137
Liver Cirrhosis, Experimental 5 | 769
Melanoma 5 | 711
Multiple myeloma 5 | 1,332
Muscle hypotonia 5 | 571
Neuropathy 5 | 261
Osteoporosis 5 | 363
Sensorineural Hearing Loss (disorder) 5 | 284
Splenomegaly 5 | 190
Status Epilepticus 5 | 98
cutaneous lupus erythematosus 5 | 1,057
interstitial cystitis 5 | 2,312
pituitary cancer 5 | 1,972
Epilepsy 4 | 792
Polycystic ovary syndrome 4 | 360
acute myeloid leukemia 4 | 783
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 22 | 12,091
Kinase 10 | 634
Enzyme 8 | 4,145
Transcription Factor 2 | 1,400

WikiPathways Pathway

Fas Ligand (FasL) pathway and ... 42 | 42
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.42514 269.0 268
Rho GDP-dissociation inhibitor 2 ARHGDIB Tbio Non-IDG -1.93968 99.3 358
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Transcriptional repressor NF-X1 NFX1 Tbio Transcription Factor -1.34294 23.4 111
FAS-associated factor 1 FAF1 Tbio Non-IDG -1.71858 56.5 209
Caspase-6 CASP6 Tchem Enzyme -2.49135 293.6 874
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150