Development Level

Tbio 11 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613

IMPC Phenotype

increased startle reflex 3 | 112
abnormal behavior 2 | 298
decreased circulating serum al... 2 | 82
decreased mean corpuscular vol... 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
preweaning lethality, incomple... 2 | 499
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 32
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24

Disease

Carcinoma 15 | 11,493
Cholestasis 12 | 155
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Cancer 9 | 2,499
diabetes mellitus 8 | 1,728
Fatty liver disease 7 | 103
Liver disease 7 | 237
Obesity 7 | 678
medulloblastoma, large-cell 7 | 6,241
psoriasis 7 | 6,694
Liver carcinoma 6 | 240
Rheumatoid arthritis 6 | 1,191
osteosarcoma 6 | 7,950
Carcinoma, Hepatocellular 5 | 228
glioblastoma 5 | 5,792
interstitial cystitis 5 | 2,312
lung cancer 5 | 4,740
Autosomal recessive predisposition 4 | 1,442
Diarrhea 4 | 253
Leber congenital amaurosis 4 | 69
astrocytoma 4 | 1,146
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
ovarian cancer 4 | 8,520
Astrocytoma, Pilocytic 3 | 3,081
Bipolar Disorder 3 | 666
Chemical and Drug Induced Liver Injury 3 | 195
Cholangitis 3 | 32
Cholelithiasis 3 | 33
Cholestasis of pregnancy 3 | 5
Intrahepatic cholestasis 3 | 20
Liver Cirrhosis, Experimental 3 | 769
Prevention of Cardiac Transplant Rejection 3 | 15
Prevention of Kidney Transplant Rejection 3 | 17
Prevention of Liver Transplant Rejection 3 | 15
Progressive intrahepatic cholestasis 3 | 4
Prostatic Neoplasms 3 | 495
Pruritus 3 | 58
Schizophrenia 3 | 1,160
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
gastric carcinoma 3 | 807
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
pediatric high grade glioma 3 | 1,064
Alkaline phosphatase serum increased 2 | 29
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Cerebrotendinous xanthomatosis 2 | 13
Cholestasis, progressive familial intrahepatic 1 2 | 3
Cholesterol gallstones 2 | 2
Colorectal Neoplasms 2 | 243
Cushing's syndrome 2 | 48
Depressive disorder 2 | 409
Diabetes Mellitus, Experimental 2 | 108
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Failure to gain weight 2 | 365
Hepatomegaly 2 | 285
Hyperglycemia 2 | 137
Hyperinsulinism 2 | 133
Icterus 2 | 82
Infantile onset 2 | 238
Keratoconjunctivitis sicca 2 | 25
Kidney cancer 2 | 2,613
Liver Cirrhosis 2 | 181
Pediatric failure to thrive 2 | 365
Polycystic ovary syndrome 2 | 360
Primary biliary cirrhosis 2 | 51
Progressive intrahepatic cholestasis (disorder) 2 | 3
Severe Recalcitrant Psoriasis 2 | 12
Sexual dysfunction 2 | 9
Splenomegaly 2 | 190
Tear film insufficiency 2 | 15
aldosterone-producing adenoma 2 | 665
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,478
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
interstitial lung disease 2 | 298
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 416
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Cholelithiasis Prevention 1 | 1
Hypertriglyceridemia result 1 | 37
Primary cholangitis 1 | 2
Serum cholesterol raised 1 | 22
Sickle Cell Anemia 1 | 53

Tissue

Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Liver and Pancreas 19 | 16,750
Skin and soft tissues 19 | 17,230
Urinary Tract 18 | 16,678
Blood and immune system 17 | 16,909
Female tissues 17 | 17,400
Male tissues 16 | 17,142
Respiratory system 14 | 16,393
Nervous System 12 | 16,725
Cardiovascular System 11 | 15,192

Target Family

Enzyme 7 | 4,145
Transporter 5 | 473
Non-IDG 3 | 12,091
Nuclear Receptor 3 | 48
Kinase 1 | 634

WikiPathways Pathway

Farnesoid X Receptor Pathway 19 | 19
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/bile acid cotransporter SLC10A1 Tchem Transporter -2.69150 476.1 163
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
Peptidyl-prolyl cis-trans isomerase FKBP5 FKBP5 Tchem Enzyme -2.52114 348.1 299
Solute carrier organic anion transporter family member 2B1 SLCO2B1 Tchem Transporter -2.10990 121.5 71
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.70498 494.6 94
Bile salt sulfotransferase SULT2A1 Tbio Enzyme -3.24754 1727.7 308
Phosphatidylcholine translocator ABCB4 ABCB4 Tbio Transporter -2.91346 806.6 146
Bile salt export pump ABCB11 Tchem Transporter -2.84131 702.2 144
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.65839 4688.0 397