Development Level

Tbio 14 | 11,445
Tchem 13 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased mean corpuscular hem... 2 | 31
increased circulating alkaline... 2 | 122
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged spleen 1 | 41
enlarged thymus 1 | 5
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased basophil cell number 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased glycosylated hemoglo... 1 | 1
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
pale yolk sac 1 | 25
pallor 1 | 34
small testis 1 | 58

Disease

Cancer 22 | 2,499
Carcinoma 21 | 11,493
ovarian cancer 20 | 8,520
osteosarcoma 17 | 7,950
diabetes mellitus 15 | 1,728
medulloblastoma, large-cell 15 | 6,241
Breast cancer 14 | 3,578
lung cancer 14 | 4,740
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
psoriasis 13 | 6,694
Kidney cancer 12 | 2,613
ependymoma 11 | 4,679
subependymal giant cell astrocytoma 11 | 2,287
oligodendroglioma 10 | 2,850
Obesity 9 | 678
Vascular disease 9 | 319
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Astrocytoma, Pilocytic 8 | 3,081
Pick disease 8 | 1,894
group 3 medulloblastoma 8 | 4,104
interstitial cystitis 8 | 2,312
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
primitive neuroectodermal tumor 8 | 3,035
Alzheimer's disease 7 | 658
Cardiomegaly 7 | 116
Hypertension 7 | 396
Kidney disease 7 | 430
Muscular atrophy 7 | 71
Schizophrenia 7 | 1,160
adrenocortical carcinoma 7 | 1,428
adult high grade glioma 7 | 3,801
group 4 medulloblastoma 7 | 1,855
pancreatic cancer 7 | 2,398
Autosomal recessive predisposition 6 | 1,442
Heart failure 6 | 162
Hyperglycemia 6 | 137
Hypertensive disease 6 | 292
Myopathy 6 | 185
breast carcinoma 6 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
pituitary cancer 6 | 1,972
tuberculosis 6 | 2,010
Autistic Disorder 5 | 364
Breast Neoplasms 5 | 445
Depressive disorder 5 | 409
Epilepsy 5 | 792
Inflammatory bowel disease 5 | 151
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Liver disease 5 | 237
Mammary Neoplasms 5 | 425
Mental Depression 5 | 333
Parkinson's disease 5 | 392
Prostatic Neoplasms 5 | 495
lung carcinoma 5 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Arthritis 4 | 290
Byzanthine arch palate 4 | 194
Carcinoma, Hepatocellular 4 | 228
Cell Transformation, Neoplastic 4 | 97
Curvature of spine 4 | 282
Diabetes Mellitus, Experimental 4 | 108
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Hyperinsulinism 4 | 133
Lipid metabolism disorder 4 | 114
Liver cancer 4 | 604
Liver carcinoma 4 | 240
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neoplasm Invasiveness 4 | 161
Pneumonia 4 | 174
Poor school performance 4 | 645
Renal Cell Carcinoma 4 | 214
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
medulloblastoma 4 | 720
progressive supranuclear palsy 4 | 676
Bipolar Disorder 3 | 666
Endometriosis 3 | 540
Hypersensitivity reaction type II disease 3 | 253
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 15 | 12,091
Kinase 10 | 634
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400

WikiPathways Pathway

Factors and pathways affecting... 31 | 31
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor ligand superfamily member 9 TNFSF9 Tbio Non-IDG -2.23604 185.9 371
Insulin-like growth factor-binding protein 5 IGFBP5 Tchem Non-IDG -2.52721 351.8 278
E3 ubiquitin-protein ligase TRIM63 TRIM63 Tbio Enzyme -2.29530 189.7 264
Growth/differentiation factor 8 MSTN Tbio Non-IDG -3.08307 1338.8 568
F-box only protein 32 FBXO32 Tbio Non-IDG -2.51378 329.8 236
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Insulin-like growth factor 1 receptor IGF1R Tclin Kinase -3.37168 2419.5 1686
JNK1/MAPK8-associated membrane protein JKAMP Tbio Non-IDG -1.12276 11.1 28
Phospholipase D1 PLD1 Tchem Enzyme -1.51188 30.9 203
Integrin-linked protein kinase ILK Tchem Kinase -2.75450 679.1 608