Development Level

Tbio 8 | 11,445

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal snout morphology 1 | 23
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
hyperactivity 1 | 148

Disease

Carcinoma 7 | 11,493
Obesity 6 | 678
medulloblastoma, large-cell 5 | 6,241
Breast cancer 4 | 3,578
atypical teratoid / rhabdoid tumor 4 | 5,112
malignant mesothelioma 4 | 3,232
ovarian cancer 4 | 8,520
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
psoriasis 3 | 6,694
Autosomal recessive predisposition 2 | 1,442
Broad flat nasal bridge 2 | 236
Congenital Heart Defects 2 | 58
Craniofacial Abnormalities 2 | 151
Depressive disorder 2 | 409
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Heart Defects, Congenital 2 | 37
Heart failure 2 | 162
Hernia, Inguinal 2 | 89
Hyperglycemia 2 | 137
Hypoparathyroidism 2 | 41
Intellectual disability 2 | 1,016
Long philtrum 2 | 137
Low set ears 2 | 181
Lung diseases 2 | 50
Lymphoid leukemia 2 | 160
Melanoma 2 | 711
Mood Disorders 2 | 184
Mood swings 2 | 77
Nasal bridge wide 2 | 236
Orbital separation excessive 2 | 244
Polycystic ovary syndrome 2 | 360
Schizophrenia 2 | 1,160
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
primitive neuroectodermal tumor 2 | 3,035
ulcerative colitis 2 | 1,819
Abnormality of the endocrine system 1 | 9
Abnormality of the pharynx 1 | 19
Acne 1 | 52
Cholelithiasis 1 | 33
Chromosome 1p36 deletion syndrome 1 | 23
Cleft uvula 1 | 27
Congenital hypoplasia of kidney 1 | 32
Convex nasal bridge 1 | 57
Cycloplegia 1 | 12
Decreased projection of midface 1 | 105
Developmental absence of tooth 1 | 7
Dysphasia 1 | 23
Endocrine System Diseases 1 | 11
Familial isolated dilated cardiomyopathy 1 | 41
Fatigable weakness of respiratory muscles 1 | 28
Fatigable weakness of swallowing muscles 1 | 28
Fractures, Bone 1 | 13
Graves Disease 1 | 11
Griscelli syndrome type 3 1 | 13
Hand deformities 1 | 32
Hernia, Femoral 1 | 7
Holt-Oram syndrome 1 | 12
Hypernasal voice 1 | 39
Hypocalcemia 1 | 32
Hypochromic anemia 1 | 9
Hypoplastic lobules 1 | 11
Impaired T cell function 1 | 14
LEFT VENTRICULAR NONCOMPACTION 10 1 | 40
LEFT VENTRICULAR NONCOMPACTION 8 1 | 40
Left ventricular noncompaction 1 | 26
Microcytic hypochromic anemia (disorder) 1 | 10
Mild Mental Retardation 1 | 70
Muscle Cramp 1 | 55
Narrow face 1 | 54
Nasal voice 1 | 39
Nonorganic psychosis 1 | 84
Open mouth 1 | 45
Overfolded helix 1 | 24
Pain 1 | 103
Prominent nasal bridge 1 | 57
Rotting teeth 1 | 73
Sloping shoulders 1 | 21
Tetany 1 | 18
Thin face 1 | 54
Thin hypoplastic alae nasi 1 | 51
Xerostomia 1 | 42
esophageal atresia/tracheoesophageal fistula 1 | 22
ulnar-mammary syndrome 1 | 8

Tissue

Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678
Blood and immune system 6 | 16,909

Target Family

Transcription Factor 4 | 1,400
Non-IDG 2 | 12,091
Enzyme 1 | 4,145
TF/Epigenetic 1 | 38

WikiPathways Pathway

FTO Obesity Variant Mechanism 8 | 8
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
AT-rich interactive domain-containing protein 5B ARID5B Tbio Transcription Factor -1.71561 54.6 97
T-box transcription factor TBX1 TBX1 Tbio Transcription Factor -1.99519 95.5 207
Iroquois-class homeodomain protein IRX-5 IRX5 Tbio Transcription Factor -1.54616 33.4 196
Iroquois-class homeodomain protein IRX-3 IRX3 Tbio Transcription Factor -1.65610 44.8 282
PR domain zinc finger protein 16 PRDM16 Tbio TF/Epigenetic -2.36324 216.4 162
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Mitochondrial brown fat uncoupling protein 1 UCP1 Tbio Non-IDG -3.12565 1273.2 279
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPARGC1A Tbio Non-IDG -2.86449 728.1 274