Development Level

Tbio 15 | 11,445
Tchem 10 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
decreased eosinophil cell numb... 1 | 24
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating glucose ... 1 | 24
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 28 | 2,499
Carcinoma 28 | 11,493
Breast cancer 22 | 3,578
ovarian cancer 22 | 8,520
lung cancer 19 | 4,740
glioblastoma 17 | 5,792
osteosarcoma 16 | 7,950
Kidney cancer 15 | 2,613
psoriasis 15 | 6,694
ependymoma 14 | 4,679
malignant mesothelioma 13 | 3,232
pancreatic cancer 13 | 2,398
Lung Neoplasms 12 | 232
atypical teratoid / rhabdoid tumor 12 | 5,112
group 3 medulloblastoma 12 | 4,104
Astrocytoma, Pilocytic 11 | 3,081
Carcinoma, Hepatocellular 11 | 228
Liver carcinoma 11 | 240
Orbital separation excessive 11 | 244
Schizophrenia 11 | 1,160
Stomach Neoplasms 11 | 300
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
medulloblastoma, large-cell 11 | 6,241
Byzanthine arch palate 10 | 194
Colorectal Neoplasms 10 | 243
Intellectual disability 10 | 1,016
breast carcinoma 10 | 1,638
interstitial cystitis 10 | 2,312
invasive ductal carcinoma 10 | 2,951
non-small cell lung cancer 10 | 2,890
Acquired scoliosis 9 | 281
Adenoma 9 | 167
Curvature of spine 9 | 282
Hypertensive disease 9 | 292
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
astrocytic glioma 9 | 2,597
diabetes mellitus 9 | 1,728
ulcerative colitis 9 | 1,819
Adenocarcinoma 8 | 122
Breast Neoplasms 8 | 445
Dull intelligence 8 | 645
Familial adenomatous polyposis 8 | 32
Liver Neoplasms, Experimental 8 | 59
Low intelligence 8 | 645
Mammary Neoplasms 8 | 425
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Neoplasm Metastasis 8 | 168
Poor school performance 8 | 645
Prostatic Neoplasms 8 | 495
Renal Cell Carcinoma 8 | 214
Somatic mutation 8 | 61
Squamous cell carcinoma 8 | 129
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
Carcinoma, Squamous Cell 7 | 110
Colonic Neoplasms 7 | 142
Coronary artery disease 7 | 268
Craniofacial Abnormalities 7 | 151
Epilepsy 7 | 792
Exophthalmos 7 | 112
Increase in blood pressure 7 | 119
Kidney disease 7 | 430
Liver Cirrhosis 7 | 181
Liver Cirrhosis, Experimental 7 | 769
Liver disease 7 | 237
Liver neoplasms 7 | 130
Ovarian Neoplasms 7 | 102
Prominent eyes 7 | 96
Prominent globes 7 | 96
Protruding eyes 7 | 96
Pulmonary Fibrosis 7 | 106
Stomach cancer 7 | 30
Thyroid cancer 7 | 36
lung adenocarcinoma 7 | 2,716
non-small cell lung carcinoma 7 | 317
ovarian neoplasm 7 | 99
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Autosomal recessive predisposition 6 | 1,442
Cognitive delay 6 | 608
Endometrial cancer 6 | 311
Global developmental delay 6 | 608
Heart disease 6 | 306
Melanoma 6 | 711
Mental and motor retardation 6 | 608
Neoplasm Invasiveness 6 | 161
Neuroblastoma 6 | 80
Pectus excavatum 6 | 100
Seizures 6 | 596
Strabismus 6 | 270
acute quadriplegic myopathy 6 | 1,158
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010

Tissue

Digestive Tract 29 | 17,369
Female tissues 29 | 17,400
Male tissues 29 | 17,142
Skin and soft tissues 29 | 17,230
Blood and immune system 28 | 16,909
Endocrine System 28 | 18,159
Liver and Pancreas 28 | 16,750
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Urinary Tract 28 | 16,678
Cardiovascular System 27 | 15,192

Target Family

Non-IDG 14 | 12,091
Kinase 8 | 634
Enzyme 5 | 4,145
Transcription Factor 3 | 1,400

WikiPathways Pathway

Extracellular vesicle-mediated... 30 | 30
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prominin-1 PROM1 Tbio Non-IDG -3.30229 2035.0 351
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Tetraspanin-8 TSPAN8 Tbio Non-IDG -1.68389 51.9 209
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982
Transforming growth factor beta-2 TGFB2 Tbio Non-IDG -3.14427 1378.3 384
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.90646 66.5 508