Development Level

Tclin 16 | 613
Tbio 9 | 11,445
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to t... 3 | 278
abnormal lens morphology 2 | 81
decreased bone mineral density 2 | 126
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased mean corpuscular vol... 1 | 79
hemorrhage 1 | 23
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Cancer 24 | 2,499
Carcinoma 22 | 11,493
osteosarcoma 17 | 7,950
ovarian cancer 17 | 8,520
lung cancer 14 | 4,740
psoriasis 14 | 6,694
medulloblastoma, large-cell 13 | 6,241
Multiple myeloma 11 | 1,332
Peripheral T-cell lymphoma 11 | 25
Primary cutaneous T-cell lymphoma 10 | 29
Schizophrenia 10 | 1,160
ependymoma 10 | 4,679
glioblastoma 10 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
adult high grade glioma 9 | 3,801
atypical teratoid / rhabdoid tumor 9 | 5,112
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
primitive neuroectodermal tumor 9 | 3,035
Alcoholic Intoxication, Chronic 8 | 289
Breast cancer 8 | 3,578
breast carcinoma 8 | 1,638
non-small cell lung cancer 8 | 2,890
Mental Depression 7 | 333
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
tuberculosis 7 | 2,010
Adverse reaction to drug 6 | 61
Alcohol dependence 6 | 107
Alcoholic Intoxication 6 | 34
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
Colorectal Neoplasms 6 | 243
Drug-Related Side Effects and Adverse Reactions 6 | 62
colon cancer 6 | 1,478
lung carcinoma 6 | 2,843
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Alcohol abuse 5 | 50
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Depressive disorder 5 | 409
Down syndrome 5 | 499
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Mood Disorders 5 | 184
Prostatic Neoplasms 5 | 495
adrenocortical carcinoma 5 | 1,428
fibroadenoma 5 | 559
nasopharyngeal carcinoma 5 | 1,058
Alcoholism 4 | 45
Atopic dermatitis 4 | 952
Cleft Lip 4 | 141
Cleft Palate 4 | 271
Disease Models, Animal 4 | 155
Endometriosis 4 | 540
Essential Hypertension 4 | 94
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Liver disease 4 | 237
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
Neoplasm Metastasis 4 | 168
Nervous System Diseases 4 | 53
Obesity 4 | 678
Substance abuse 4 | 59
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
nervous system disorder 4 | 53
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
spina bifida 4 | 1,074
subependymal giant cell astrocytoma 4 | 2,287
Anemia 3 | 365
Autistic Disorder 3 | 364
Bipolar Disorder 3 | 666
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Cocaine-Related Disorders 3 | 92
Colonic Neoplasms 3 | 142
Epilepsy 3 | 792
Infertility, Male 3 | 46
Liver carcinoma 3 | 240
Male infertility 3 | 206
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Unipolar Depression 3 | 250
Urinary Bladder Neoplasms 3 | 114
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
substance-related disorder 3 | 162
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Nervous System 30 | 16,725

Target Family

Enzyme 14 | 4,145
Epigenetic 14 | 242
Non-IDG 1 | 12,091
Transcription Factor 1 | 1,400
Transporter 1 | 473

WikiPathways Pathway

Ethanol effects on histone mod... 31 | 31
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Folate transporter 1 SLC19A1 Tchem Transporter -2.00363 97.7 67
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
Aldehyde dehydrogenase family 1 member A3 ALDH1A3 Tbio Enzyme -1.98798 93.8 120
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725