Development Level

Tbio 27 | 11,445
Tchem 14 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating magnesiu... 2 | 13
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased glycosylated hemoglo... 1 | 1
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 36 | 11,493
osteosarcoma 33 | 7,950
medulloblastoma, large-cell 31 | 6,241
ovarian cancer 31 | 8,520
glioblastoma 22 | 5,792
psoriasis 21 | 6,694
Cancer 20 | 2,499
atypical teratoid / rhabdoid tumor 20 | 5,112
ependymoma 20 | 4,679
adult high grade glioma 17 | 3,801
lung cancer 17 | 4,740
primitive neuroectodermal tumor 17 | 3,035
Obesity 15 | 678
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
diabetes mellitus 14 | 1,728
Schizophrenia 12 | 1,160
group 4 medulloblastoma 12 | 1,855
malignant mesothelioma 12 | 3,232
subependymal giant cell astrocytoma 12 | 2,287
oligodendroglioma 11 | 2,850
Astrocytoma, Pilocytic 10 | 3,081
Breast cancer 10 | 3,578
Pick disease 10 | 1,894
astrocytic glioma 10 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Bipolar Disorder 9 | 666
Rheumatoid arthritis 9 | 1,191
Vascular disease 9 | 319
Hyperglycemia 8 | 137
Parkinson's disease 8 | 392
astrocytoma 8 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
Diabetes Mellitus, Experimental 7 | 108
Fatty liver disease 7 | 103
Kidney cancer 7 | 2,613
Prostatic Neoplasms 7 | 495
acute quadriplegic myopathy 7 | 1,158
dermatomyositis 7 | 966
pituitary cancer 7 | 1,972
Alzheimer's disease 6 | 658
Cardiomegaly 6 | 116
Waldenstrons macroglobulinemia 6 | 765
lung adenocarcinoma 6 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Breast Neoplasms 5 | 445
Depressive disorder 5 | 409
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Endometriosis 5 | 540
Heart disease 5 | 306
Heart failure 5 | 162
Insulin Resistance 5 | 72
Mammary Neoplasms 5 | 425
Mood Disorders 5 | 184
Multiple myeloma 5 | 1,332
colon cancer 5 | 1,478
non-small cell lung cancer 5 | 2,890
ulcerative colitis 5 | 1,819
Atherosclerosis 4 | 291
Cardiomyopathies 4 | 110
Fatty Liver 4 | 70
Hyperinsulinism 4 | 133
Hypertension 4 | 396
Hypertensive disease 4 | 292
Intellectual disability 4 | 1,016
Mental Depression 4 | 333
Multiple Sclerosis 4 | 540
Myocardial Infarction 4 | 151
Stomach Neoplasms 4 | 300
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,312
pediatric high grade glioma 4 | 1,064
Acute kidney injury 3 | 70
Adenocarcinoma of lung 3 | 142
Alcoholic Intoxication, Chronic 3 | 289
Alzheimer Disease 3 | 83
Arthritis 3 | 290
Cerebrovascular accident 3 | 63
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Dementia 3 | 175
Epilepsy 3 | 792
Hepatomegaly 3 | 285
Huntington's disease 3 | 76
Kidney disease 3 | 430
Liver neoplasms 3 | 130
Major Depressive Disorder 3 | 301
Mammary Neoplasms, Experimental 3 | 154
Melanoma 3 | 711
Nerve Degeneration 3 | 121
Toxic encephalopathy 3 | 141
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
spina bifida 3 | 1,074

Tissue

Endocrine System 46 | 18,159
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Urinary Tract 44 | 16,678

Target Family

Transcription Factor 10 | 1,400
Enzyme 9 | 4,145
Kinase 8 | 634
Non-IDG 8 | 12,091
Epigenetic 6 | 242
Nuclear Receptor 5 | 48

WikiPathways Pathway

Energy Metabolism 46 | 46
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.60752 391.4 125
GA-binding protein alpha chain GABPA Tbio Transcription Factor -1.50283 31.7 289
Steroid hormone receptor ERR1 ESRRA Tchem Nuclear Receptor -2.13451 156.7 356
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 PPRC1 Tbio Non-IDG -2.48090 295.1 100
Myb-binding protein 1A MYBBP1A Tbio Non-IDG -1.24204 21.4 192