Development Level

Tbio 15 | 11,445
Tchem 11 | 1,598
Tclin 9 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal lens morphology 1 | 81
abnormal sensory capabilities-... 1 | 8
abnormal spleen morphology 1 | 55
absent vibrissae 1 | 12
cataract 1 | 92
decreased circulating alkaline... 1 | 46
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
limb grasping 1 | 41
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 25 | 11,493
ovarian cancer 23 | 8,520
medulloblastoma, large-cell 21 | 6,241
glioblastoma 19 | 5,792
lung cancer 18 | 4,740
atypical teratoid / rhabdoid tumor 17 | 5,112
Cancer 16 | 2,499
ependymoma 14 | 4,679
primitive neuroectodermal tumor 14 | 3,035
psoriasis 14 | 6,694
adult high grade glioma 13 | 3,801
Hypertension 12 | 396
group 3 medulloblastoma 12 | 4,104
invasive ductal carcinoma 12 | 2,951
lung adenocarcinoma 12 | 2,716
oligodendroglioma 12 | 2,850
astrocytic glioma 11 | 2,597
osteosarcoma 11 | 7,950
pancreatic cancer 11 | 2,398
Kidney cancer 10 | 2,613
Kidney disease 10 | 430
Pick disease 10 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung carcinoma 10 | 2,843
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 9 | 3,578
Heart disease 9 | 306
Hypertensive disease 9 | 292
Obesity 9 | 678
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
Schizophrenia 8 | 1,160
Depressive disorder 7 | 409
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Heart failure 7 | 162
Liver cancer 7 | 604
Pulmonary hypertension 7 | 85
Substance Withdrawal Syndrome 7 | 55
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
tuberculosis 7 | 2,010
Adenoma 6 | 167
Bipolar Disorder 6 | 666
Cushing's syndrome 6 | 48
Diabetes Mellitus, Experimental 6 | 108
Diabetes Mellitus, Type 2 6 | 142
Epilepsy 6 | 792
Hyperthyroidism 6 | 53
Hypoparathyroidism 6 | 41
Hypothyroidism 6 | 122
Osteoporosis 6 | 363
breast carcinoma 6 | 1,638
diabetes mellitus 6 | 1,728
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Asthma 5 | 385
Brachydactyly 5 | 156
Cardiomegaly 5 | 116
Cerebrovascular disease 5 | 238
Cognitive delay 5 | 608
Coronary artery disease 5 | 268
Fibrous dysplasia 5 | 15
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Major Depressive Disorder 5 | 301
McCune Albright syndrome 5 | 19
Mental Depression 5 | 333
Mental and motor retardation 5 | 608
Migraine 5 | 83
Polycystic ovary syndrome 5 | 360
Pseudohypoparathyroidism 5 | 18
Seizures 5 | 596
Short stature 5 | 531
Unipolar Depression 5 | 250
adrenocortical carcinoma 5 | 1,428
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
Acromegaly 4 | 51
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Brain Ischemia 4 | 110
Cardiovascular Diseases 4 | 59
Essential Hypertension 4 | 94
Hyperalgesia 4 | 83
Hyperparathyroidism 4 | 48
Hypophosphatemia 4 | 40
Liver Cirrhosis 4 | 181
Melanoma 4 | 711
Mood Disorders 4 | 184
Pituitary adenoma 4 | 38
Skin cancer 4 | 469
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
substance-related disorder 4 | 162

Tissue

Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Blood and immune system 30 | 16,909
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Liver and Pancreas 29 | 16,750
Respiratory system 29 | 16,393
Cardiovascular System 28 | 15,192
Female tissues 28 | 17,400

Target Family

Non-IDG 17 | 12,091
GPCR 7 | 408
Enzyme 6 | 4,145
Kinase 5 | 634
Transporter 1 | 473

WikiPathways Pathway

Endothelin Pathways 36 | 36
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Pro-neuropeptide Y NPY Tbio Non-IDG -3.83401 7433.3 432
Alpha-1A adrenergic receptor ADRA1A Tclin GPCR -2.18682 155.5 236
Calponin-1 CNN1 Tbio Non-IDG -2.21051 158.8 466
CAD protein CAD Tchem Non-IDG -2.23887 168.4 224
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509