Development Level

Tbio 28 | 11,651
Tchem 23 | 1,388
Tclin 12 | 612

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal embryo size 3 | 220
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating creatini... 2 | 39
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal embryo development 1 | 7
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
increased B cell number 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Cancer 50 | 2,499
Carcinoma 49 | 11,493
ovarian cancer 48 | 8,520
osteosarcoma 39 | 7,950
glioblastoma 36 | 5,792
atypical teratoid / rhabdoid tumor 35 | 5,112
medulloblastoma, large-cell 33 | 6,241
psoriasis 33 | 6,694
Breast cancer 30 | 3,578
lung cancer 30 | 4,740
Kidney cancer 25 | 2,613
ependymoma 23 | 4,679
group 3 medulloblastoma 23 | 4,104
Breast Neoplasms 22 | 445
Prostatic Neoplasms 22 | 495
Mammary Neoplasms 21 | 425
Schizophrenia 21 | 1,160
Stomach Neoplasms 21 | 300
malignant mesothelioma 21 | 3,232
oligodendroglioma 21 | 2,850
Lung Neoplasms 20 | 232
breast carcinoma 20 | 1,638
invasive ductal carcinoma 19 | 2,951
Intellectual disability 18 | 1,016
Orbital separation excessive 18 | 244
primitive neuroectodermal tumor 18 | 3,035
Dull intelligence 17 | 645
Epilepsy 17 | 792
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Seizures 17 | 596
pancreatic cancer 17 | 2,398
Adenoma 16 | 167
Byzanthine arch palate 16 | 194
Cognitive delay 16 | 608
Downward slant of palpebral fissure 16 | 158
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Vascular disease 16 | 319
adult high grade glioma 16 | 3,801
subependymal giant cell astrocytoma 16 | 2,287
Astrocytoma, Pilocytic 15 | 3,081
Colorectal Neoplasms 15 | 243
Concave bridge of nose 15 | 195
Depressed nasal bridge 15 | 195
Depressed nasal root/bridge 15 | 195
High forehead 15 | 102
Hypoplastic mandible condyle 15 | 275
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Strabismus 15 | 270
Tall forehead 15 | 102
Big calvaria 14 | 147
Blepharoptosis 14 | 231
Carcinoma, Hepatocellular 14 | 228
Colonic Neoplasms 14 | 142
Frontal bossing 14 | 157
Increased head circumference 14 | 147
Increased size of cranium 14 | 147
Increased size of skull 14 | 147
Liver carcinoma 14 | 240
Muscle hypotonia 14 | 571
Renal Cell Carcinoma 14 | 214
Short stature 14 | 531
astrocytic glioma 14 | 2,597
diabetes mellitus 14 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
juvenile dermatomyositis 14 | 1,187
Autosomal recessive predisposition 13 | 1,442
Cryptorchidism 13 | 296
Endometrial cancer 13 | 311
Melanoma 13 | 711
Neoplasm Metastasis 13 | 168
Ovarian Neoplasms 13 | 102
Rheumatoid arthritis 13 | 1,191
Squamous cell carcinoma 13 | 129
adrenocortical carcinoma 13 | 1,428
ductal carcinoma in situ 13 | 1,745
Acquired scoliosis 12 | 281
Adenocarcinoma 12 | 122
Carcinoma, Squamous Cell 12 | 110
Curvature of spine 12 | 282
Familial adenomatous polyposis 12 | 32
Lymphoid leukemia 12 | 160
Multiple myeloma 12 | 1,332
Pectus excavatum 12 | 100
astrocytoma 12 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
non-small cell lung cancer 12 | 2,890
ovarian neoplasm 12 | 99
Immune system cancer 11 | 140
Obesity 11 | 678
Pick disease 11 | 1,894
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung adenocarcinoma 11 | 2,716
pituitary cancer 11 | 1,972
ulcerative colitis 11 | 1,819

Tissue

Blood and immune system 62 | 16,909
Digestive Tract 62 | 17,369
Endocrine System 62 | 18,159
Female tissues 62 | 17,400
Liver and Pancreas 62 | 16,750
Male tissues 62 | 17,142
Nervous System 62 | 16,725
Skin and soft tissues 62 | 17,230
Urinary Tract 62 | 16,678
Respiratory system 61 | 16,393
Cardiovascular System 60 | 15,192

Target Family

Non-IDG 23 | 12,091
Kinase 22 | 634
Enzyme 9 | 4,145
Transcription Factor 9 | 1,400

WikiPathways Pathway

Endometrial cancer 63 | 63
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Catenin alpha-2 CTNNA2 Tbio Non-IDG -1.98557 99.5 74
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Integrin-linked protein kinase ILK Tchem Kinase -2.75450 679.1 608
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.33582 220.9 1431