Development Level

Tbio 110 | 11,445
Tchem 22 | 1,598
Tdark 7 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 8 | 499
increased bone mineral density 4 | 72
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
increased or absent threshold ... 3 | 101
male infertility 3 | 123
abnormal bone structure 2 | 187
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
corneal opacity 2 | 32
decreased CD4-positive, alpha ... 2 | 7
decreased T cell number 2 | 15
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating glycerol... 2 | 16
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
hypoactivity 2 | 132
increased B cell number 2 | 9
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal iris morphology 1 | 13
abnormal limb morphology 1 | 13
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
absent startle reflex 1 | 24
cataract 1 | 92
decreased CD8-positive, alpha-... 1 | 8
decreased IgG1 level 1 | 8
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased T cell number 1 | 6
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
long tibia 1 | 25
mammalian phenotype 1 | 17
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
short tibia 1 | 97
syndactyly 1 | 23

Disease

Carcinoma 115 | 11,493
ovarian cancer 79 | 8,520
osteosarcoma 73 | 7,950
lung cancer 67 | 4,740
Cancer 60 | 2,499
glioblastoma 59 | 5,792
medulloblastoma, large-cell 57 | 6,241
psoriasis 57 | 6,694
atypical teratoid / rhabdoid tumor 52 | 5,112
Breast cancer 47 | 3,578
malignant mesothelioma 45 | 3,232
group 3 medulloblastoma 44 | 4,104
ependymoma 43 | 4,679
primitive neuroectodermal tumor 40 | 3,035
Kidney cancer 36 | 2,613
non-small cell lung cancer 35 | 2,890
invasive ductal carcinoma 34 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
adult high grade glioma 32 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
oligodendroglioma 31 | 2,850
lung adenocarcinoma 30 | 2,716
Astrocytoma, Pilocytic 29 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
interstitial cystitis 28 | 2,312
astrocytic glioma 27 | 2,597
pancreatic cancer 25 | 2,398
lung carcinoma 24 | 2,843
breast carcinoma 22 | 1,638
ulcerative colitis 22 | 1,819
group 4 medulloblastoma 21 | 1,855
cystic fibrosis 20 | 1,696
ductal carcinoma in situ 19 | 1,745
subependymal giant cell astrocytoma 19 | 2,287
tuberculosis 19 | 2,010
colon cancer 18 | 1,478
pediatric high grade glioma 18 | 1,064
Intellectual disability 17 | 1,016
cutaneous lupus erythematosus 16 | 1,057
diabetes mellitus 16 | 1,728
esophageal adenocarcinoma 16 | 737
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
pituitary cancer 16 | 1,972
Breast Neoplasms 15 | 445
Multiple myeloma 15 | 1,332
Pick disease 15 | 1,894
Short stature 15 | 531
Mammary Neoplasms 14 | 425
Prostatic Neoplasms 14 | 495
juvenile dermatomyositis 14 | 1,187
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Schizophrenia 13 | 1,160
Waldenstrons macroglobulinemia 13 | 765
adrenocortical carcinoma 13 | 1,428
gastric carcinoma 13 | 807
primary pancreatic ductal adenocarcinoma 13 | 1,109
spina bifida 13 | 1,074
Alzheimer's disease 12 | 658
Autosomal recessive predisposition 12 | 1,442
Craniofacial Abnormalities 12 | 151
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Rheumatoid arthritis 12 | 1,191
acute quadriplegic myopathy 12 | 1,158
dermatomyositis 12 | 966
medulloblastoma 12 | 720
Muscle hypotonia 11 | 571
nasopharyngeal carcinoma 11 | 1,058
Cryptorchidism 10 | 296
Epilepsy 10 | 792
Failure to gain weight 10 | 365
Multiple Sclerosis 10 | 540
Pediatric failure to thrive 10 | 365
primary Sjogren syndrome 10 | 735
Kidney disease 9 | 430
Liver cancer 9 | 604
Seizures 9 | 596
Strabismus 9 | 270
posterior fossa group A ependymoma 9 | 468
Bipolar Disorder 8 | 666
Chronic obstructive pulmonary disease 8 | 184
Cleft Palate 8 | 271
Colorectal Neoplasms 8 | 243
Hypertension 8 | 396
Liver Cirrhosis, Experimental 8 | 769
Orbital separation excessive 8 | 244
Osteoporosis 8 | 363
Small head 8 | 374
active ulcerative colitis 8 | 764
acute myeloid leukemia 8 | 783
astrocytoma 8 | 1,146
atypical teratoid/rhabdoid tumor 8 | 357
sarcoidosis 8 | 370
Crohn's disease 7 | 321
Hypertensive disease 7 | 292

Tissue

Endocrine System 139 | 18,159
Digestive Tract 135 | 17,369
Female tissues 134 | 17,400
Skin and soft tissues 134 | 17,230
Blood and immune system 133 | 16,909
Urinary Tract 133 | 16,678
Male tissues 132 | 17,142
Liver and Pancreas 131 | 16,750
Nervous System 131 | 16,725
Respiratory system 130 | 16,393
Cardiovascular System 120 | 15,192

Target Family

Non-IDG 53 | 12,091
Transcription Factor 50 | 1,400
Enzyme 19 | 4,145
Epigenetic 9 | 242
Kinase 4 | 634
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38
Transporter 2 | 473

WikiPathways Pathway

Endoderm Differentiation 141 | 141
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
MBT domain-containing protein 1 MBTD1 Tdark Epigenetic -0.59314 4.06 83
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Transcription factor SOX-21 SOX21 Tbio Transcription Factor -1.47198 29.1 106
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
Transcription factor SOX-7 SOX7 Tbio Transcription Factor -1.69107 35.6 169
Condensin-2 complex subunit G2 NCAPG2 Tbio Non-IDG -0.75957 5.48 110
Sestrin-1 SESN1 Tbio Non-IDG -1.95681 82.0 172