Development Level

Tbio 32 | 10,625
Tchem 21 | 1,890
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavior 3 | 226
decreased lean body mass 3 | 195
abnormal embryo size 2 | 112
decreased bone mineral content 2 | 157
decreased monocyte cell number 2 | 28
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal testis morphology 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive T-hel... 1 | 2
decreased body length 1 | 108
decreased circulating calcium ... 1 | 33
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased monocyte cell number 1 | 27
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
small testis 1 | 37
straub tail 1 | 26

Disease

ovarian cancer 44 | 8,484
osteosarcoma 39 | 7,933
psoriasis 39 | 6,685
Cancer 35 | 2,346
Breast cancer 32 | 3,094
glioblastoma 30 | 5,572
invasive ductal carcinoma 29 | 2,950
medulloblastoma, large-cell 28 | 6,234
lung cancer 26 | 4,466
pilocytic astrocytoma 26 | 3,086
atypical teratoid / rhabdoid tumor 24 | 4,369
malignant mesothelioma 24 | 3,162
non-small cell lung cancer 24 | 2,798
pancreatic cancer 24 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
ulcerative colitis 23 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
lung adenocarcinoma 22 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pediatric high grade glioma 21 | 2,712
breast carcinoma 20 | 1,614
ductal carcinoma in situ 20 | 1,745
lung carcinoma 19 | 2,844
cystic fibrosis 17 | 1,665
diabetes mellitus 17 | 1,663
interstitial cystitis 17 | 2,299
oligodendroglioma 17 | 2,849
primary pancreatic ductal adenocarcinoma 17 | 1,271
Osteoarthritis 16 | 96
pituitary cancer 16 | 1,972
group 4 medulloblastoma 15 | 1,875
Osteoporosis 14 | 257
adrenocortical carcinoma 14 | 1,427
ependymoma 14 | 2,514
colon cancer 13 | 1,475
posterior fossa group A ependymoma 13 | 1,511
Alzheimer's disease 12 | 644
Atopic dermatitis 12 | 944
Carcinoma 12 | 2,147
Endometriosis 12 | 535
Kidney disease 12 | 396
Obesity 12 | 616
subependymal giant cell astrocytoma 12 | 2,287
Arthritis 11 | 248
Prostatic Neoplasms 11 | 471
Adenoma 10 | 165
Liver Cirrhosis, Experimental 10 | 108
gastric carcinoma 10 | 832
group 3 medulloblastoma 10 | 2,254
posterior fossa group B ependymoma 10 | 1,530
sonic hedgehog group medulloblastoma 10 | 1,482
Atherosclerosis 9 | 275
Craniofacial Abnormalities 9 | 147
Heart disease 9 | 279
astrocytoma 9 | 1,493
cutaneous lupus erythematosus 9 | 1,056
nasopharyngeal carcinoma 9 | 1,056
non-small cell lung carcinoma 9 | 413
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
tuberculosis 9 | 1,557
Asthma 8 | 349
Cleft palate 8 | 125
Down syndrome 8 | 548
Hypertension 8 | 287
Liver disease 8 | 219
Mammary Neoplasms 8 | 410
Pick disease 8 | 1,893
astrocytic glioma 8 | 2,241
medulloblastoma 8 | 1,524
Achondroplasia 7 | 20
IGA Glomerulonephritis 7 | 454
Liver Cirrhosis 7 | 101
Lung disease 7 | 132
Pulmonary Fibrosis 7 | 66
adult high grade glioma 7 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
chronic rhinosinusitis 7 | 512
esophageal adenocarcinoma 7 | 737
fibroadenoma 7 | 557
primitive neuroectodermal tumor 7 | 3,031
Coronary artery disease 6 | 240
Craniosynostosis 6 | 47
Duchenne muscular dystrophy 6 | 602
Hypersensitivity reaction type II disease 6 | 235
Hypothyroidism 6 | 89
Inflammation 6 | 109
Inflammatory bowel disease 6 | 142
Liver carcinoma 6 | 217
Lung Neoplasms 6 | 171
Multiple myeloma 6 | 1,327
Neoplasm Metastasis 6 | 138
Polycystic Ovary Syndrome 6 | 332
Rheumatoid Arthritis 6 | 1,160
Spontaneous abortion 6 | 108
Vascular disease 6 | 281
active Crohn's disease 6 | 918
acute quadriplegic myopathy 6 | 1,157
periodontitis 6 | 269
primary Sjogren syndrome 6 | 789
sarcoidosis 6 | 358

Tissue

Endocrine System 62 | 18,512
Female tissues 62 | 18,647
Nervous System 62 | 18,561
Urinary Tract 62 | 18,444
Blood and immune system 61 | 17,995
Digestive Tract 61 | 18,473
Liver and Pancreas 61 | 18,136
Male tissues 61 | 17,969
Respiratory system 60 | 17,484
Skin and soft tissues 60 | 18,115
Cardiovascular System 59 | 17,958

Target Family

Non-IDG 27 | 11,971
Enzyme 14 | 4,146
Transcription Factor 10 | 1,400
Kinase 7 | 634
Epigenetic 1 | 242
GPCR 1 | 406
Nuclear Receptor 1 | 48
Transporter 1 | 473

WikiPathways Pathway

Endochondral Ossification 62 | 62
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Serpin H1 SERPINH1 Tbio Non-IDG -3.13545 1424.1 295
A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAMTS4 Tchem Enzyme -1.59386 46.6 337
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17963 1388.1 188
Cyclin-dependent kinase inhibitor 1C CDKN1C Tbio Enzyme -2.77104 600.5 488
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.97848 10115.4 658
Bone morphogenetic protein 6 BMP6 Tbio Non-IDG -2.48343 339.1 259
Parathyroid hormone-related protein PTHLH Tchem Non-IDG -3.25775 2090.5 248
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.83412 76.6 133