Development Level

Tbio 70 | 11,445
Tchem 30 | 1,598
Tclin 16 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 4 | 239
enlarged heart 4 | 210
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
cataract 3 | 92
decreased body weight 3 | 161
decreased vertical activity 3 | 208
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal brain morphology 2 | 13
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal startle reflex 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
impaired pupillary reflex 2 | 26
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased spleen weight 1 | 10
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating insulin ... 1 | 3
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 86 | 11,493
Cancer 78 | 2,499
ovarian cancer 61 | 8,520
osteosarcoma 60 | 7,950
psoriasis 56 | 6,694
glioblastoma 46 | 5,792
lung cancer 46 | 4,740
Breast cancer 44 | 3,578
atypical teratoid / rhabdoid tumor 44 | 5,112
medulloblastoma, large-cell 44 | 6,241
ependymoma 36 | 4,679
group 3 medulloblastoma 36 | 4,104
malignant mesothelioma 34 | 3,232
oligodendroglioma 31 | 2,850
non-small cell lung cancer 26 | 2,890
invasive ductal carcinoma 25 | 2,951
adult high grade glioma 24 | 3,801
breast carcinoma 24 | 1,638
lung adenocarcinoma 24 | 2,716
Breast Neoplasms 23 | 445
Kidney cancer 23 | 2,613
Mammary Neoplasms 23 | 425
Orbital separation excessive 23 | 244
Short stature 23 | 531
astrocytic glioma 23 | 2,597
Astrocytoma, Pilocytic 22 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
pancreatic cancer 22 | 2,398
Schizophrenia 21 | 1,160
colon cancer 21 | 1,478
Autosomal recessive predisposition 20 | 1,442
Hypoplastic mandible condyle 20 | 275
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
lung carcinoma 20 | 2,843
pituitary cancer 20 | 1,972
Cleft Palate 19 | 271
Intellectual disability 19 | 1,016
Osteoporosis 19 | 363
Prostatic Neoplasms 19 | 495
cystic fibrosis 19 | 1,696
diabetes mellitus 19 | 1,728
interstitial cystitis 19 | 2,312
Cryptorchidism 18 | 296
Downward slant of palpebral fissure 18 | 158
Epilepsy 18 | 792
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
subependymal giant cell astrocytoma 18 | 2,287
Cognitive delay 17 | 608
Dull intelligence 17 | 645
Global developmental delay 17 | 608
Low intelligence 17 | 645
Lung Neoplasms 17 | 232
Mental Retardation 17 | 645
Mental and motor retardation 17 | 608
Mental deficiency 17 | 645
Pick disease 17 | 1,894
Poor school performance 17 | 645
Seizures 17 | 596
astrocytoma 17 | 1,146
ductal carcinoma in situ 16 | 1,745
tuberculosis 16 | 2,010
Carcinoma, Hepatocellular 15 | 228
Liver carcinoma 15 | 240
Obesity 15 | 678
Strabismus 15 | 270
Vascular disease 15 | 319
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primitive neuroectodermal tumor 15 | 3,035
ulcerative colitis 15 | 1,819
Adenoma 14 | 167
Big calvaria 14 | 147
Blepharoptosis 14 | 231
Byzanthine arch palate 14 | 194
Cleft Lip 14 | 141
Concave bridge of nose 14 | 195
Depressed nasal bridge 14 | 195
Depressed nasal root/bridge 14 | 195
Depressive disorder 14 | 409
Frontal bossing 14 | 157
High forehead 14 | 102
Increased head circumference 14 | 147
Increased size of cranium 14 | 147
Increased size of skull 14 | 147
Parkinson's disease 14 | 392
Tall forehead 14 | 102
adrenocortical carcinoma 14 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Acquired scoliosis 13 | 281
Curvature of spine 13 | 282
Decreased projection of midface 13 | 105
Hypotrophic midface 13 | 105
Midface retrusion 13 | 105
Muscle hypotonia 13 | 571
Small midface 13 | 105
group 4 medulloblastoma 13 | 1,855
Hepatomegaly 12 | 285
Multiple myeloma 12 | 1,332
Pectus excavatum 12 | 100
Rheumatoid arthritis 12 | 1,191

Tissue

Endocrine System 113 | 18,159
Digestive Tract 111 | 17,369
Female tissues 111 | 17,400
Male tissues 110 | 17,142
Nervous System 110 | 16,725
Skin and soft tissues 110 | 17,230
Urinary Tract 108 | 16,678
Blood and immune system 107 | 16,909
Liver and Pancreas 107 | 16,750
Respiratory system 103 | 16,393
Cardiovascular System 97 | 15,192

Target Family

Non-IDG 59 | 12,091
Kinase 31 | 634
Transcription Factor 11 | 1,400
GPCR 9 | 408
Enzyme 6 | 4,145

WikiPathways Pathway

ESC Pluripotency Pathways 116 | 116
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Actin-related protein 2 ACTR2 Tbio Non-IDG -1.88412 78.5 211