Development Level

Tchem 8 | 1,598
Tbio 4 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal coat appearance 1 | 31
abnormal lens morphology 1 | 81
abnormal rib morphology 1 | 10
cataract 1 | 92
decreased circulating creatini... 1 | 39
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 12 | 11,493
Cancer 11 | 2,499
glioblastoma 11 | 5,792
Schizophrenia 9 | 1,160
medulloblastoma, large-cell 9 | 6,241
ovarian cancer 9 | 8,520
atypical teratoid / rhabdoid tumor 8 | 5,112
osteosarcoma 7 | 7,950
Alcoholic Intoxication, Chronic 6 | 289
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Toxic encephalopathy 6 | 141
Unipolar Depression 6 | 250
adult high grade glioma 6 | 3,801
group 3 medulloblastoma 6 | 4,104
lung cancer 6 | 4,740
psoriasis 6 | 6,694
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Cocaine-Related Disorders 5 | 92
Epilepsy 5 | 792
Kidney cancer 5 | 2,613
Lung Neoplasms 5 | 232
Major Depressive Disorder 5 | 301
Pick disease 5 | 1,894
Short stature 5 | 531
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Autistic Disorder 4 | 364
Bipolar Disorder 4 | 666
Blepharoptosis 4 | 231
Cerebrovascular disease 4 | 238
Cognitive delay 4 | 608
Cryptorchidism 4 | 296
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Huntington's disease 4 | 76
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Depression 4 | 333
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Neoplasm Invasiveness 4 | 161
Obesity 4 | 678
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Status Epilepticus 4 | 98
Stomach Neoplasms 4 | 300
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Brain Ischemia 3 | 110
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Squamous Cell 3 | 110
Dementia 3 | 175
Diarrhea 3 | 253
Disease Progression 3 | 136
Downward slant of palpebral fissure 3 | 158
Exanthem 3 | 37
Heart disease 3 | 306
Hypoplastic mandible condyle 3 | 275
Liver carcinoma 3 | 240
Low set ears 3 | 181
Mammary Neoplasms, Experimental 3 | 154
Mandibular hypoplasia 3 | 275
Melanoma 3 | 711
Micrognathism 3 | 275
Mood Disorders 3 | 184
Muscle hypotonia 3 | 571
Neoplasm Metastasis 3 | 168
Nerve Degeneration 3 | 121
Neurodegenerative disease 3 | 414
Noonan syndrome 3 | 34
Paronychia 3 | 7
Precancerous Conditions 3 | 80
Squamous cell carcinoma 3 | 129
Substance Withdrawal Syndrome 3 | 55
Vascular disease 3 | 319
astrocytoma 3 | 1,146
esophageal adenocarcinoma 3 | 737
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
ulcerative colitis 3 | 1,819
Gliosis 2 | 56
Hyperreflexia 2 | 209
Liver Cirrhosis, Experimental 2 | 769
Neuropathy 2 | 261
Pilocytic astrocytoma 2 | 56

Tissue

Cardiovascular System 14 | 15,192
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Urinary Tract 14 | 16,678
Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Liver and Pancreas 13 | 16,750
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230

Target Family

Kinase 6 | 634
Enzyme 3 | 4,145
Non-IDG 2 | 12,091
Transcription Factor 2 | 1,400
GPCR 1 | 408

WikiPathways Pathway

ERK Pathway in Huntington's Di... 14 | 14
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Brain-derived neurotrophic factor BDNF Tbio Non-IDG -4.00507 10701.6 723
BDNF/NT-3 growth factors receptor NTRK2 Tchem Kinase -3.14477 1170.3 947
Metabotropic glutamate receptor 1 GRM1 Tchem GPCR -3.05662 1115.6 490
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689