Development Level

Tbio 109 | 11,651
Tchem 40 | 1,388
Tclin 6 | 612
Tdark 4 | 6,593

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
decreased vertical activity 5 | 208
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating total pr... 3 | 49
embryonic lethality prior to t... 3 | 278
increased blood urea nitrogen ... 3 | 48
increased circulating triglyce... 3 | 42
increased mean corpuscular hem... 3 | 96
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal brain morphology 1 | 13
abnormal coat-hair pigmentatio... 1 | 64
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal thyroid gland morphol... 1 | 3
abnormal tooth morphology 1 | 24
abnormal trachea morphology 1 | 3
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
absent lymph nodes 1 | 3
anophthalmia 1 | 33
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydroencephaly 1 | 14
hydrometra 1 | 53
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 120 | 11,493
Cancer 101 | 2,499
ovarian cancer 96 | 8,520
psoriasis 84 | 6,694
osteosarcoma 77 | 7,950
atypical teratoid / rhabdoid tumor 71 | 5,112
glioblastoma 68 | 5,792
lung cancer 65 | 4,740
Breast cancer 63 | 3,578
ependymoma 54 | 4,679
medulloblastoma, large-cell 54 | 6,241
interstitial cystitis 48 | 2,312
pancreatic cancer 45 | 2,398
Astrocytoma, Pilocytic 43 | 3,081
group 3 medulloblastoma 41 | 4,104
primitive neuroectodermal tumor 41 | 3,035
malignant mesothelioma 40 | 3,232
Kidney cancer 39 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 39 | 2,716
cystic fibrosis 38 | 1,696
non-small cell lung cancer 38 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
ductal carcinoma in situ 36 | 1,745
oligodendroglioma 36 | 2,850
adult high grade glioma 35 | 3,801
Breast Neoplasms 34 | 445
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
Mammary Neoplasms 33 | 425
breast carcinoma 33 | 1,638
lung carcinoma 31 | 2,843
subependymal giant cell astrocytoma 30 | 2,287
astrocytic glioma 29 | 2,597
juvenile dermatomyositis 29 | 1,187
pituitary cancer 28 | 1,972
Schizophrenia 26 | 1,160
Autosomal recessive predisposition 25 | 1,442
Orbital separation excessive 25 | 244
adrenocortical carcinoma 25 | 1,428
ulcerative colitis 25 | 1,819
Kidney disease 24 | 430
nasopharyngeal carcinoma 22 | 1,058
Prostatic Neoplasms 21 | 495
Short stature 21 | 531
diabetes mellitus 21 | 1,728
gastric carcinoma 21 | 807
primary pancreatic ductal adenocarcinoma 21 | 1,109
Hypoplastic mandible condyle 20 | 275
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
Pick disease 20 | 1,894
group 4 medulloblastoma 20 | 1,855
Acquired scoliosis 19 | 281
Curvature of spine 19 | 282
colon cancer 19 | 1,478
pediatric high grade glioma 19 | 1,064
tuberculosis 19 | 2,010
Neoplasm Metastasis 18 | 168
Osteoporosis 18 | 363
acute quadriplegic myopathy 18 | 1,158
dermatomyositis 18 | 966
Byzanthine arch palate 17 | 194
Epilepsy 17 | 792
Lung Neoplasms 17 | 232
Neoplasm Invasiveness 17 | 161
Seizures 17 | 596
Strabismus 17 | 270
astrocytoma 17 | 1,146
Cell Transformation, Neoplastic 16 | 97
Hypertensive disease 16 | 292
Neoplastic Cell Transformation 16 | 89
Stomach Neoplasms 16 | 300
Vascular disease 16 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
Carcinoma, Squamous Cell 15 | 110
Cognitive delay 15 | 608
Cryptorchidism 15 | 296
Global developmental delay 15 | 608
Intellectual disability 15 | 1,016
Liver Cirrhosis, Experimental 15 | 769
Mental and motor retardation 15 | 608
Muscle hypotonia 15 | 571
Rheumatoid arthritis 15 | 1,191
acute myeloid leukemia 15 | 783
Concave bridge of nose 14 | 195
Depressed nasal bridge 14 | 195
Depressed nasal root/bridge 14 | 195
Duchenne muscular dystrophy 14 | 601
Dull intelligence 14 | 645
Liver cancer 14 | 604
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
active ulcerative colitis 14 | 764
posterior fossa group A ependymoma 14 | 468
Cataract 13 | 297
esophageal adenocarcinoma 13 | 737
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962

Tissue

Digestive Tract 157 | 17,369
Endocrine System 156 | 18,159
Female tissues 156 | 17,400
Skin and soft tissues 153 | 17,230
Urinary Tract 152 | 16,678
Blood and immune system 151 | 16,909
Male tissues 151 | 17,142
Nervous System 151 | 16,725
Liver and Pancreas 148 | 16,750
Respiratory system 146 | 16,393
Cardiovascular System 136 | 15,192

Target Family

Non-IDG 91 | 12,091
Kinase 26 | 634
Transcription Factor 20 | 1,400
Enzyme 10 | 4,145
GPCR 10 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

WikiPathways Pathway

EMT transition in Colorectal C... 159 | 159
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Claudin-8 CLDN8 Tbio Non-IDG -1.50382 29.7 184
Claudin-6 CLDN6 Tbio Non-IDG -1.76879 66.0 370
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
Myocyte-specific enhancer factor 2D MEF2D Tbio Transcription Factor -1.96264 88.6 323
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222