Development Level

Tbio 84 | 10,625
Tchem 64 | 1,890
Tclin 14 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

abnormal bone structure 6 | 131
preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 6 | 260
decreased lean body mass 5 | 195
decreased bone mineral content 4 | 157
decreased grip strength 4 | 123
abnormal behavior 3 | 226
abnormal retina morphology 3 | 100
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased circulating fructosa... 3 | 31
decreased leukocyte cell numbe... 3 | 54
decreased mature B cell number 3 | 25
decreased mean corpuscular hem... 3 | 34
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
abnormal coping response 2 | 12
abnormal posture 2 | 5
abnormal sleep behavior 2 | 63
abnormal tooth morphology 2 | 24
decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased mean corpuscular vol... 2 | 50
increased bone mineral content 2 | 92
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
persistence of hyaloid vascula... 2 | 22
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased heart weight 1 | 44
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 37
increased prepulse inhibition 1 | 21
increased vertical activity 1 | 18
long tibia 1 | 13
short tibia 1 | 82

Disease

ovarian cancer 117 | 8,484
osteosarcoma 97 | 7,933
Cancer 96 | 2,346
medulloblastoma, large-cell 82 | 6,234
glioblastoma 80 | 5,572
psoriasis 72 | 6,685
lung cancer 65 | 4,466
atypical teratoid / rhabdoid tumor 61 | 4,369
oligodendroglioma 49 | 2,849
Carcinoma 45 | 2,147
Breast cancer 44 | 3,094
ependymoma 43 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
pilocytic astrocytoma 43 | 3,086
primitive neuroectodermal tumor 42 | 3,031
subependymal giant cell astrocytoma 42 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
pancreatic cancer 40 | 2,300
pediatric high grade glioma 40 | 2,712
malignant mesothelioma 39 | 3,162
non-small cell lung cancer 39 | 2,798
group 4 medulloblastoma 38 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
invasive ductal carcinoma 37 | 2,950
Pick disease 34 | 1,893
astrocytoma 34 | 1,493
lung adenocarcinoma 33 | 2,713
astrocytic glioma 32 | 2,241
pituitary cancer 31 | 1,972
juvenile dermatomyositis 30 | 1,189
ulcerative colitis 30 | 2,087
lung carcinoma 28 | 2,844
diabetes mellitus 27 | 1,663
interstitial cystitis 27 | 2,299
Rheumatoid Arthritis 26 | 1,160
medulloblastoma 26 | 1,524
adult high grade glioma 25 | 2,148
Mammary Neoplasms 24 | 410
breast carcinoma 23 | 1,614
ductal carcinoma in situ 23 | 1,745
Multiple myeloma 22 | 1,327
dermatomyositis 22 | 933
acute quadriplegic myopathy 21 | 1,157
tuberculosis 20 | 1,557
Vascular disease 19 | 281
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
posterior fossa group A ependymoma 19 | 1,511
primary pancreatic ductal adenocarcinoma 19 | 1,271
spina bifida 18 | 1,064
Lung Neoplasms 17 | 171
Parkinson's disease 17 | 364
Prostatic Neoplasms 17 | 471
colon cancer 17 | 1,475
Neoplasm Metastasis 16 | 138
Obesity 16 | 616
primary Sjogren syndrome 16 | 789
Alzheimer's disease 15 | 644
Heart disease 15 | 279
Waldenstrons macroglobulinemia 15 | 765
adrenocortical carcinoma 15 | 1,427
group 3 medulloblastoma 15 | 2,254
Neoplasm Invasiveness 14 | 127
nasopharyngeal carcinoma 14 | 1,056
sonic hedgehog group medulloblastoma 14 | 1,482
Adenocarcinoma 13 | 115
Intellectual disability 13 | 573
Liver carcinoma 13 | 217
Stomach Neoplasms 13 | 282
tuberculosis and treatment for 6 months 13 | 686
Melanoma 12 | 261
Noonan Syndrome 12 | 33
aldosterone-producing adenoma 12 | 664
cystic fibrosis 12 | 1,665
Hypertensive disease 11 | 193
Kidney disease 11 | 396
Mammary Neoplasms, Experimental 11 | 150
Multiple Sclerosis 11 | 498
atypical teratoid/rhabdoid tumor 11 | 1,095
cutaneous lupus erythematosus 11 | 1,056
esophageal adenocarcinoma 11 | 737
Animal Mammary Neoplasms 10 | 136
Arthritis 10 | 248
Cardiomegaly 10 | 66
Endometriosis 10 | 535
Epilepsy 10 | 346
Renal Cell Carcinoma 10 | 199
acute myeloid leukemia 10 | 780
pancreatic carcinoma 10 | 567
Adenoma 9 | 165
Amyotrophic Lateral Sclerosis 9 | 431
Chronic Lymphocytic Leukemia 9 | 242
Down syndrome 9 | 548
Duchenne muscular dystrophy 9 | 602
IGA Glomerulonephritis 9 | 454
Liver neoplasms 9 | 109
Myocardial Ischemia 9 | 169
Reperfusion Injury 9 | 84
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
gastric carcinoma 9 | 832
progressive supranuclear palsy 9 | 674

Tissue

Blood and immune system 162 | 17,995
Cardiovascular System 162 | 17,958
Digestive Tract 162 | 18,473
Endocrine System 162 | 18,512
Female tissues 162 | 18,647
Liver and Pancreas 162 | 18,136
Male tissues 162 | 17,969
Nervous System 162 | 18,561
Respiratory system 162 | 17,484
Skin and soft tissues 162 | 18,115
Urinary Tract 162 | 18,444

Target Family

Non-IDG 56 | 11,971
Kinase 47 | 634
Enzyme 36 | 4,146
Transcription Factor 22 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

EGF/EGFR Signaling Pathway 162 | 162
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Ras-related protein Ral-B RALB Tbio Enzyme -1.69182 49.7 204
Ras-related protein Ral-A RALA Tbio Enzyme -2.17133 159.2 185
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424