Development Level

Tbio 95 | 11,651
Tchem 53 | 1,388
Tclin 14 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 14 | 979
abnormal bone structure 8 | 187
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 5 | 278
abnormal retina morphology 4 | 71
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
embryonic lethality prior to o... 4 | 239
increased neutrophil cell numb... 4 | 46
abnormal heart morphology 3 | 162
abnormal skin morphology 3 | 50
decreased circulating fructosa... 3 | 30
enlarged heart 3 | 210
enlarged kidney 3 | 14
increased circulating alkaline... 3 | 122
increased lymphocyte cell numb... 3 | 32
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal sleep behavior 2 | 70
abnormal tooth morphology 2 | 24
decreased caudal vertebrae num... 2 | 53
decreased circulating chloride... 2 | 30
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating creatine... 1 | 4
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased lactate dehydrogenas... 1 | 3
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased vertical activity 1 | 24
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 130 | 11,493
ovarian cancer 118 | 8,520
Cancer 97 | 2,499
osteosarcoma 97 | 7,950
glioblastoma 82 | 5,792
medulloblastoma, large-cell 82 | 6,241
psoriasis 72 | 6,694
lung cancer 71 | 4,740
atypical teratoid / rhabdoid tumor 66 | 5,112
ependymoma 64 | 4,679
Breast cancer 51 | 3,578
adult high grade glioma 50 | 3,801
oligodendroglioma 49 | 2,850
Kidney cancer 47 | 2,613
group 3 medulloblastoma 46 | 4,104
astrocytic glioma 44 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
primitive neuroectodermal tumor 42 | 3,035
subependymal giant cell astrocytoma 42 | 2,287
malignant mesothelioma 41 | 3,232
pancreatic cancer 41 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
non-small cell lung cancer 40 | 2,890
Astrocytoma, Pilocytic 39 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
invasive ductal carcinoma 37 | 2,951
Pick disease 34 | 1,894
group 4 medulloblastoma 34 | 1,855
lung adenocarcinoma 33 | 2,716
pituitary cancer 31 | 1,972
juvenile dermatomyositis 30 | 1,187
diabetes mellitus 28 | 1,728
lung carcinoma 28 | 2,843
Rheumatoid arthritis 27 | 1,191
interstitial cystitis 27 | 2,312
breast carcinoma 26 | 1,638
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
tuberculosis 25 | 2,010
ulcerative colitis 25 | 1,819
Multiple myeloma 23 | 1,332
ductal carcinoma in situ 23 | 1,745
astrocytoma 22 | 1,146
dermatomyositis 22 | 966
Intellectual disability 21 | 1,016
Schizophrenia 21 | 1,160
Short stature 21 | 531
acute quadriplegic myopathy 21 | 1,158
Lung Neoplasms 20 | 232
Orbital separation excessive 20 | 244
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Autosomal recessive predisposition 19 | 1,442
Muscle hypotonia 19 | 571
Vascular disease 19 | 319
Epilepsy 18 | 792
Melanoma 18 | 711
Prostatic Neoplasms 18 | 495
primary pancreatic ductal adenocarcinoma 18 | 1,109
spina bifida 18 | 1,074
Neoplasm Metastasis 17 | 168
Parkinson's disease 17 | 392
colon cancer 17 | 1,478
Blepharoptosis 16 | 231
Concave bridge of nose 16 | 195
Depressed nasal bridge 16 | 195
Depressed nasal root/bridge 16 | 195
Heart disease 16 | 306
Hypertensive disease 16 | 292
Carcinoma, Hepatocellular 15 | 228
Cognitive delay 15 | 608
Dull intelligence 15 | 645
Global developmental delay 15 | 608
Liver Cirrhosis, Experimental 15 | 769
Liver carcinoma 15 | 240
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental and motor retardation 15 | 608
Mental deficiency 15 | 645
Poor school performance 15 | 645
Seizures 15 | 596
Stomach Neoplasms 15 | 300
Waldenstrons macroglobulinemia 15 | 765
adrenocortical carcinoma 15 | 1,428
pediatric high grade glioma 15 | 1,064
Acquired scoliosis 14 | 281
Adenocarcinoma 14 | 122
Alzheimer's disease 14 | 658
Byzanthine arch palate 14 | 194
Curvature of spine 14 | 282
Depressive disorder 14 | 409
Downward slant of palpebral fissure 14 | 158
Frontal bossing 14 | 157
Hypertension 14 | 396
Neoplasm Invasiveness 14 | 161
Obesity 14 | 678
nasopharyngeal carcinoma 14 | 1,058
primary Sjogren syndrome 14 | 735
cystic fibrosis 13 | 1,696
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275

Tissue

Blood and immune system 162 | 16,909
Digestive Tract 162 | 17,369
Endocrine System 162 | 18,159
Female tissues 162 | 17,400
Male tissues 162 | 17,142
Nervous System 162 | 16,725
Respiratory system 162 | 16,393
Skin and soft tissues 162 | 17,230
Urinary Tract 162 | 16,678
Liver and Pancreas 161 | 16,750
Cardiovascular System 160 | 15,192

Target Family

Non-IDG 56 | 12,091
Kinase 47 | 634
Enzyme 36 | 4,145
Transcription Factor 22 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

EGF/EGFR Signaling Pathway 162 | 162
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Protein fosB FOSB Tbio Transcription Factor -2.66286 432.2 328
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249