Development Level

Tchem 15 | 1,598
Tbio 7 | 11,445
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Cancer 19 | 2,499
Carcinoma 15 | 11,493
glioblastoma 13 | 5,792
ovarian cancer 13 | 8,520
psoriasis 12 | 6,694
osteosarcoma 10 | 7,950
Rheumatoid arthritis 9 | 1,191
lung cancer 9 | 4,740
Arthritis 8 | 290
Asthma 8 | 385
atypical teratoid / rhabdoid tumor 8 | 5,112
tuberculosis 8 | 2,010
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Hypersensitivity reaction type II disease 6 | 253
Inflammatory bowel disease 6 | 151
Multiple Sclerosis 6 | 540
acute myeloid leukemia 6 | 783
diabetes mellitus 6 | 1,728
non-small cell lung cancer 6 | 2,890
Arthritis, Rheumatoid 5 | 174
Brain Ischemia 5 | 110
Cholestasis, Extrahepatic 5 | 25
Coronary artery disease 5 | 268
Lung disease 5 | 142
Obesity 5 | 678
Pneumonia 5 | 174
Schizophrenia 5 | 1,160
adult high grade glioma 5 | 3,801
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
ependymoma 5 | 4,679
interstitial cystitis 5 | 2,312
lung adenocarcinoma 5 | 2,716
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
Astrocytoma, Pilocytic 4 | 3,081
Atherosclerosis 4 | 291
Bipolar Disorder 4 | 666
Bronchiectasis 4 | 64
Cell Transformation, Neoplastic 4 | 97
Colitis, Ulcerative 4 | 59
Colonic Neoplasms 4 | 142
Dermatitis 4 | 157
Heat Stroke 4 | 13
Hyperalgesia 4 | 83
Hypertension 4 | 396
Immunologic Deficiency Syndromes 4 | 113
Influenza 4 | 142
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Malaria 4 | 160
Multiple myeloma 4 | 1,332
Neoplasm Invasiveness 4 | 161
Neoplastic Cell Transformation 4 | 89
Reperfusion Injury 4 | 86
Stomach Neoplasms 4 | 300
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Allergic hypersensitivity disease 3 | 126
Allergic rhinitis 3 | 94
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Cholestasis 3 | 155
Colitis 3 | 54
Depressive disorder 3 | 409
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Disease Models, Animal 3 | 155
Endometriosis 3 | 540
Heart disease 3 | 306
Hypereosinophilic syndrome 3 | 71
Keratitis 3 | 62
Leukopenia 3 | 72
Liver carcinoma 3 | 240
Liver disease 3 | 237
Lung Neoplasms 3 | 232
Meningitis 3 | 67
Mental Depression 3 | 333
Mood Disorders 3 | 184
Neoplasm Metastasis 3 | 168
Osteoporosis 3 | 363
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Prostatic Neoplasms 3 | 495
Severe acute respiratory syndrome 3 | 27
Urinary Bladder Neoplasms 3 | 114
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
esophageal adenocarcinoma 3 | 737
mucosa-associated lymphoid tissue lymphoma 3 | 484
oligodendroglioma 3 | 2,850
primary pancreatic ductal adenocarcinoma 3 | 1,109
sarcoidosis 3 | 370

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Cardiovascular System 20 | 15,192

Target Family

Non-IDG 11 | 12,091
Kinase 9 | 634
Transcription Factor 3 | 1,400

WikiPathways Pathway

EBV LMP1 signaling 23 | 23
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-C motif chemokine 20 CCL20 Tbio Non-IDG -3.10283 1250.3 496
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.73612 54.7 183
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
C-C motif chemokine 5 CCL5 Tchem Non-IDG -3.39732 2431.2 660
Interferon beta IFNB1 Tbio Non-IDG -3.83887 6789.5 731