Development Level

Tchem 8 | 1,890
Tbio 6 | 10,625
Tclin 3 | 602

IMPC Phenotype

increased circulating alanine ... 2 | 11
increased circulating aspartat... 2 | 17
abnormal behavior 1 | 226
abnormal lung morphology 1 | 15
abnormal retina morphology 1 | 100
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased mean corpuscular hem... 1 | 34
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased kidney weight 1 | 4
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
preweaning lethality, incomple... 1 | 260

Disease

Cholestasis 15 | 93
Cancer 11 | 2,346
Liver disease 8 | 219
osteosarcoma 8 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Bilirubin metabolic disorder 7 | 39
Rheumatoid Arthritis 7 | 1,170
Leber congenital amaurosis 6 | 72
lung cancer 6 | 4,473
ulcerative colitis 6 | 2,087
Carcinoma 5 | 2,147
Colorectal Neoplasms 5 | 217
Drug-Induced Liver Injury 5 | 118
Obesity 5 | 616
Peripheral Neuropathy 5 | 303
active Crohn's disease 5 | 918
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
malignant mesothelioma 5 | 3,163
Adverse reaction to drug 4 | 54
Fatty liver disease 4 | 86
Mammary Neoplasms 4 | 410
Metabolic syndrome X 4 | 155
Prostatic Neoplasms 4 | 471
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
ovarian cancer 4 | 8,491
tuberculosis 4 | 1,563
Biliary cirrhosis 3 | 33
Epilepsy 3 | 346
Inflammatory bowel disease 3 | 142
Liver Cirrhosis, Experimental 3 | 108
Neonatal jaundice 3 | 15
Neutropenia 3 | 78
Osteoporosis 3 | 259
aldosterone-producing adenoma 3 | 664
medulloblastoma, large-cell 3 | 6,234
non-small cell lung carcinoma 3 | 413
posterior fossa group A ependymoma 3 | 1,511
psoriasis 3 | 6,685
Alopecia 2 | 55
Cerebrotendinous xanthomatosis 2 | 12
Cholangitis 2 | 20
Cholelithiasis 2 | 14
Cholestasis of pregnancy 2 | 5
Esophageal Neoplasms 2 | 67
Hepatomegaly 2 | 10
Hypertension 2 | 293
Hypophosphatemia 2 | 31
Intrahepatic cholestasis 2 | 19
Keratoconjunctivitis sicca 2 | 19
Kidney disease 2 | 397
Liver carcinoma 2 | 217
Liver neoplasms 2 | 108
Neoplasm Metastasis 2 | 138
Prevention of Cardiac Transplant Rejection 2 | 14
Prevention of Kidney Transplant Rejection 2 | 16
Prevention of Liver Transplant Rejection 2 | 14
Primary biliary cirrhosis 2 | 45
Progressive intrahepatic cholestasis 2 | 4
Schizophrenia 2 | 503
Sclerosing cholangitis 2 | 17
Severe Recalcitrant Psoriasis 2 | 11
Sexual dysfunction 2 | 10
Squamous cell carcinoma of the head and neck 2 | 24
Tear film insufficiency 2 | 14
Type 2 diabetes mellitus 2 | 192
adrenocortical carcinoma 2 | 1,427
atypical teratoid / rhabdoid tumor 2 | 4,369
cystic fibrosis 2 | 1,670
esophageal adenocarcinoma 2 | 737
glioblastoma 2 | 5,572
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
nephrosclerosis 2 | 329
nervous system disorder 2 | 53
pancreatic cancer 2 | 2,300
pilocytic astrocytoma 2 | 3,086
Barrett Esophagus 1 | 20
Calculus in biliary tract 1 | 2
Cholelithiasis Prevention 1 | 1
Diarrhea 1 | 155
Diffuse large B-cell lymphoma 1 | 42
Extravasation of Diagnostic and Therapeutic Materials 1 | 6
HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 1 | 6
Heart Diseases 1 | 42
Hepatitis D 1 | 10
Hyperinsulinism 1 | 63
Hypoactive sexual desire disorder 1 | 9
Hypoparathyroidism 1 | 29
Intestinal Neoplasms 1 | 11
Liver Neoplasms, Experimental 1 | 48
Organ system cancer 1 | 15
Ornithine carbamoyltransferase deficiency 1 | 13
Primary cholangitis 1 | 2
Prinzmetal angina 1 | 6
Sickle Cell Anemia 1 | 54
Uremia 1 | 19

Tissue

Blood and immune system 17 | 17,994
Digestive Tract 17 | 18,472
Endocrine System 17 | 18,511
Female tissues 17 | 18,646
Liver and Pancreas 17 | 18,135
Male tissues 17 | 17,968
Nervous System 17 | 18,560
Urinary Tract 17 | 18,443
Cardiovascular System 16 | 17,957
Respiratory system 16 | 17,483
Skin and soft tissues 16 | 18,114

Target Family

Transporter 9 | 473
Enzyme 4 | 4,146
Nuclear Receptor 4 | 48

WikiPathways Pathway

Drug Induction of Bile Acid Pa... 17 | 17
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bile salt export pump ABCB11 Tchem Transporter -2.80557 639.9 130
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.12272 1473.5 263
Multidrug resistance protein 1 ABCB1 Tchem Transporter -3.58391 3760.3 500
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.58949 3546.8 508
Bile salt sulfotransferase SULT2A1 Tchem Enzyme -3.22796 1662.7 274
Canalicular multispecific organic anion transporter 2 ABCC3 Tbio Transporter -2.43554 279.8 196
Multidrug resistance-associated protein 4 ABCC4 Tbio Transporter -2.52810 316.0 288
Canalicular multispecific organic anion transporter 1 ABCC2 Tbio Transporter -2.87447 792.5 227
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.67775 466.5 87
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.63616 4494.0 323