Development Level

Tbio 8 | 11,651
Tchem 6 | 1,388
Tclin 3 | 612

IMPC Phenotype

decreased mean corpuscular vol... 3 | 79
decreased circulating serum al... 2 | 82
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased kidney weight 1 | 6
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24

Disease

Cholestasis 15 | 155
Carcinoma 14 | 11,493
Cancer 11 | 2,499
Liver disease 9 | 237
Rheumatoid arthritis 8 | 1,191
osteosarcoma 8 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Bilirubin metabolic disorder 7 | 41
lung cancer 7 | 4,740
Chemical and Drug Induced Liver Injury 6 | 195
Leber congenital amaurosis 6 | 69
Obesity 6 | 678
diabetes mellitus 6 | 1,728
Autosomal recessive predisposition 5 | 1,442
Colorectal Neoplasms 5 | 243
Kidney cancer 5 | 2,613
active Crohn's disease 5 | 922
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
Adverse reaction to drug 4 | 61
Arthritis, Rheumatoid 4 | 174
Breast Neoplasms 4 | 445
Drug-Related Side Effects and Adverse Reactions 4 | 62
Fatty liver disease 4 | 103
Hepatomegaly 4 | 285
Liver Cirrhosis, Experimental 4 | 769
Mammary Neoplasms 4 | 425
Prostatic Neoplasms 4 | 495
active ulcerative colitis 4 | 764
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
ovarian cancer 4 | 8,520
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Biliary cirrhosis 3 | 45
Conjugated hyperbilirubinemia 3 | 14
Diarrhea 3 | 253
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Icterus 3 | 82
Inflammatory bowel disease 3 | 151
Keratoconjunctivitis sicca 3 | 25
Liver Cirrhosis, Biliary 3 | 33
Liver carcinoma 3 | 240
Neonatal Jaundice 3 | 30
Neutropenia 3 | 72
Osteoporosis 3 | 363
Pediatric failure to thrive 3 | 365
Prevention of Cardiac Transplant Rejection 3 | 15
Prevention of Kidney Transplant Rejection 3 | 17
Prevention of Liver Transplant Rejection 3 | 15
Schizophrenia 3 | 1,160
Severe Recalcitrant Psoriasis 3 | 12
Tear film insufficiency 3 | 15
aldosterone-producing adenoma 3 | 665
medulloblastoma, large-cell 3 | 6,241
non-small cell lung carcinoma 3 | 317
posterior fossa group A ependymoma 3 | 468
psoriasis 3 | 6,694
Alkaline phosphatase serum increased 2 | 29
Alopecia 2 | 115
Astrocytoma, Pilocytic 2 | 3,081
Bipolar Disorder 2 | 666
Carcinoma, Hepatocellular 2 | 228
Carcinoma, squamous cell of head and neck 2 | 31
Cerebrotendinous xanthomatosis 2 | 13
Cholangitis 2 | 32
Cholestasis of pregnancy 2 | 5
Cushing's syndrome 2 | 48
Esophageal Neoplasms 2 | 69
Hypertension 2 | 396
Hypophosphatemia 2 | 40
Infantile onset 2 | 238
Intrahepatic cholestasis 2 | 20
Kidney disease 2 | 430
Liver cancer 2 | 604
Liver neoplasms 2 | 130
Malaria 2 | 160
Metabolic syndrome X 2 | 52
Myopathy 2 | 185
Neoplasm Metastasis 2 | 168
Nervous System Diseases 2 | 53
Primary biliary cirrhosis 2 | 51
Progressive intrahepatic cholestasis 2 | 4
Pruritus 2 | 58
Rickets 2 | 49
Squamous cell carcinoma of the head and neck 2 | 29
Type 2 diabetes mellitus 2 | 272
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
glioblastoma 2 | 5,792
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
nephrosclerosis 2 | 333
nervous system disorder 2 | 53
pancreatic cancer 2 | 2,398

Tissue

Endocrine System 17 | 18,159
Liver and Pancreas 17 | 16,750
Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Skin and soft tissues 16 | 17,230
Female tissues 15 | 17,400
Urinary Tract 15 | 16,678
Male tissues 14 | 17,142
Respiratory system 12 | 16,393
Nervous System 11 | 16,725
Cardiovascular System 7 | 15,192

Target Family

Transporter 9 | 473
Enzyme 4 | 4,145
Nuclear Receptor 4 | 48

WikiPathways Pathway

Drug Induction of Bile Acid Pa... 17 | 17
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Solute carrier organic anion transporter family member 1B1 SLCO1B1 Tchem Transporter -2.77788 574.0 124
Nuclear receptor subfamily 1 group I member 3 NR1I3 Tchem Nuclear Receptor -2.57140 281.2 304
Organic solute transporter subunit alpha SLC51A Tbio Transporter -1.94606 84.5 82
Canalicular multispecific organic anion transporter 2 ABCC3 Tbio Transporter -2.46032 287.4 214
Multidrug resistance-associated protein 4 ABCC4 Tbio Transporter -2.56001 341.6 352
Canalicular multispecific organic anion transporter 1 ABCC2 Tbio Transporter -2.90204 834.9 234
Multidrug resistance protein 1 ABCB1 Tchem Transporter -3.61827 4039.4 875
Bile salt sulfotransferase SULT2A1 Tbio Enzyme -3.24754 1727.7 308
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.15331 1582.6 305