Development Level

Tbio 18 | 11,445
Tchem 7 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
embryonic lethality prior to t... 2 | 278
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal sleep behavior 1 | 70
abnormal social-conspecific in... 1 | 3
anophthalmia 1 | 33
cleft palate 1 | 8
cyanosis 1 | 7
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased coping response 1 | 4
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
preweaning lethality, incomple... 1 | 499
shortened ST segment 1 | 10

Disease

Carcinoma 22 | 11,493
Parkinson's disease 15 | 392
psoriasis 15 | 6,694
Schizophrenia 14 | 1,160
Cancer 13 | 2,499
medulloblastoma, large-cell 13 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
osteosarcoma 11 | 7,950
glioblastoma 10 | 5,792
Cleft Palate 9 | 271
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
pituitary cancer 9 | 1,972
Depressive disorder 8 | 409
Short stature 8 | 531
group 3 medulloblastoma 8 | 4,104
lung cancer 8 | 4,740
ovarian cancer 8 | 8,520
Bipolar Disorder 7 | 666
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
Alcoholic Intoxication, Chronic 6 | 289
Astrocytoma, Pilocytic 6 | 3,081
Breast cancer 6 | 3,578
Epilepsy 6 | 792
Holoprosencephaly 6 | 56
Parkinsonian Disorders 6 | 56
Seizures 6 | 596
group 4 medulloblastoma 6 | 1,855
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
Abnormally small eyeball 5 | 97
Acquired scoliosis 5 | 281
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Cleft Lip 5 | 141
Congenital hypoplasia of penis 5 | 176
Constipation 5 | 181
Cryptorchidism 5 | 296
Curvature of spine 5 | 282
Decreased size of eyeball 5 | 97
Dyschezia 5 | 135
Microphthalmos 5 | 100
Muscle hypotonia 5 | 571
Nerve Degeneration 5 | 121
Nervous System Diseases 5 | 53
Polydactyly 5 | 107
Strabismus 5 | 270
Uranostaphyloschisis 5 | 167
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
esophageal adenocarcinoma 5 | 737
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
medulloblastoma 5 | 720
nervous system disorder 5 | 53
oligodendroglioma 5 | 2,850
Axial hypotonia 4 | 46
Blepharoptosis 4 | 231
Carcinoma, Hepatocellular 4 | 228
Dystonia 4 | 164
Dystonia, Limb 4 | 9
Gastroesophageal reflux disease 4 | 110
Generalized osteopenia 4 | 99
Heartburn 4 | 78
Hyperhidrosis disorder 4 | 81
Hypogonadism, Isolated Hypogonadotropic 4 | 71
Hypogonadotropic hypogonadism 4 | 89
Increased sweating 4 | 81
Infantile onset 4 | 238
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Major Depressive Disorder 4 | 301
Microphthalmia 4 | 76
Osteopenia 4 | 99
Osteoporosis 4 | 363
Prostatic Neoplasms 4 | 495
Small testicle 4 | 75
Sweating 4 | 81
aldosterone-producing adenoma 4 | 665
breast carcinoma 4 | 1,638
chronic rhinosinusitis 4 | 512
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
ulcerative colitis 4 | 1,819
Attention deficit hyperactivity disorder 3 | 278
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Mental Depression 3 | 333
cystic fibrosis 3 | 1,696
fibroadenoma 3 | 559
spina bifida 3 | 1,074

Tissue

Endocrine System 30 | 18,159
Female tissues 27 | 17,400
Nervous System 25 | 16,725
Digestive Tract 24 | 17,369
Skin and soft tissues 24 | 17,230
Liver and Pancreas 22 | 16,750
Male tissues 21 | 17,142
Urinary Tract 21 | 16,678
Blood and immune system 19 | 16,909
Respiratory system 18 | 16,393
Cardiovascular System 15 | 15,192

Target Family

Transcription Factor 18 | 1,400
Enzyme 4 | 4,145
Non-IDG 4 | 12,091
Transporter 2 | 473
Kinase 1 | 634
Nuclear Receptor 1 | 48

WikiPathways Pathway

Dopaminergic Neurogenesis 30 | 30
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.44791 277.6 405
Sodium-dependent dopamine transporter SLC6A3 Tclin Transporter -3.59848 3752.4 324
Cyclin-dependent kinase inhibitor 1C CDKN1C Tbio Enzyme -2.81199 631.0 665
Aromatic-L-amino-acid decarboxylase DDC Tclin Enzyme -2.78263 593.3 412
Homeobox protein engrailed-2 EN2 Tbio Transcription Factor -2.40698 255.2 208
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725
Pituitary homeobox 3 PITX3 Tbio Transcription Factor -2.26232 188.5 134
Neurogenin-2 NEUROG2 Tbio Transcription Factor -2.14943 138.7 288