Development Level

Tbio 27 | 11,445
Tchem 13 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 3 | 278
decreased body weight 2 | 161
decreased lean body mass 2 | 135
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
corneal opacity 1 | 32
decreased B cell number 1 | 5
decreased bone mineral content 1 | 151
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
enlarged lymph nodes 1 | 37
female infertility 1 | 60
fused cornea and lens 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased startle reflex 1 | 112
iris synechia 1 | 3
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Cancer 39 | 2,499
Carcinoma 30 | 11,493
osteosarcoma 21 | 7,950
psoriasis 21 | 6,694
lung cancer 19 | 4,740
malignant mesothelioma 19 | 3,232
ovarian cancer 19 | 8,520
Breast cancer 18 | 3,578
medulloblastoma, large-cell 18 | 6,241
cystic fibrosis 17 | 1,696
glioblastoma 16 | 5,792
lung carcinoma 15 | 2,843
ulcerative colitis 14 | 1,819
Arthritis 13 | 290
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Osteoporosis 13 | 363
atypical teratoid / rhabdoid tumor 13 | 5,112
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
invasive ductal carcinoma 13 | 2,951
pancreatic cancer 13 | 2,398
Schizophrenia 12 | 1,160
ependymoma 12 | 4,679
Astrocytoma, Pilocytic 11 | 3,081
Cleft Palate 11 | 271
Depressive disorder 11 | 409
Heart disease 11 | 306
Liver Cirrhosis, Experimental 11 | 769
interstitial cystitis 11 | 2,312
Anemia 10 | 365
Atherosclerosis 10 | 291
Autosomal recessive predisposition 10 | 1,442
Kidney disease 10 | 430
Pulmonary Fibrosis 10 | 106
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
Hypertension 9 | 396
Neoplasm Metastasis 9 | 168
breast carcinoma 9 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
non-small cell lung cancer 9 | 2,890
Alzheimer's disease 8 | 658
Bipolar Disorder 8 | 666
Carcinoma, Hepatocellular 8 | 228
Cleft Lip 8 | 141
Coronary artery disease 8 | 268
Liver carcinoma 8 | 240
Liver disease 8 | 237
Neurodegenerative disease 8 | 414
Prostatic Neoplasms 8 | 495
Short stature 8 | 531
astrocytic glioma 8 | 2,597
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,855
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
Asthma 7 | 385
Brain disease 7 | 96
Cerebrovascular disease 7 | 238
Lung disease 7 | 142
Mental Depression 7 | 333
Myocardial Ischemia 7 | 169
Neoplasm Invasiveness 7 | 161
Neuropathy 7 | 261
Obesity 7 | 678
Rheumatoid arthritis 7 | 1,191
Thrombocytopenia 7 | 197
adult high grade glioma 7 | 3,801
oligodendroglioma 7 | 2,850
Acute kidney injury 6 | 70
Autistic Disorder 6 | 364
Cell Transformation, Neoplastic 6 | 97
Cognitive delay 6 | 608
Diabetic retinopathy 6 | 56
Global developmental delay 6 | 608
Hypertensive disease 6 | 292
Inflammation 6 | 120
Kidney cancer 6 | 2,613
Liver Cirrhosis 6 | 181
Mental and motor retardation 6 | 608
Mesothelioma, Malignant 6 | 105
Neoplastic Cell Transformation 6 | 89
Parkinson's disease 6 | 392
Polydactyly 6 | 107
non-small cell lung carcinoma 6 | 317
subependymal giant cell astrocytoma 6 | 2,287
Abortion, Spontaneous 5 | 109
Arthritis, Rheumatoid 5 | 174
Atopic dermatitis 5 | 952
Endometriosis 5 | 540
Polycystic ovary syndrome 5 | 360
Spontaneous abortion 5 | 113
Synostosis 5 | 15
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
mucosa-associated lymphoid tissue lymphoma 5 | 484
pediatric high grade glioma 5 | 1,064
primitive neuroectodermal tumor 5 | 3,035

Tissue

Endocrine System 47 | 18,159
Digestive Tract 46 | 17,369
Female tissues 46 | 17,400
Respiratory system 46 | 16,393
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Nervous System 43 | 16,725
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 4 | 4,145
Kinase 3 | 634
GPCR 1 | 408

WikiPathways Pathway

Differentiation Pathway 48 | 48
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
ALK tyrosine kinase receptor ALK Tclin Kinase -3.44312 2942.9 976
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Fms-related tyrosine kinase 3 ligand FLT3LG Tbio Enzyme -2.31017 235.2 270
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Thyroid peroxidase TPO Tclin Enzyme -2.83776 580.4 368