Development Level

Tbio 35 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 3 | 220
embryonic growth retardation 2 | 106
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96

Disease

group 3 medulloblastoma 30 | 4,104
malignant mesothelioma 28 | 3,232
non-small cell lung cancer 28 | 2,890
lung cancer 27 | 4,740
Carcinoma 26 | 11,493
ovarian cancer 26 | 8,520
medulloblastoma, large-cell 24 | 6,241
psoriasis 23 | 6,694
glioblastoma 22 | 5,792
primitive neuroectodermal tumor 21 | 3,035
adrenocortical carcinoma 20 | 1,428
osteosarcoma 20 | 7,950
atypical teratoid / rhabdoid tumor 19 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Breast cancer 14 | 3,578
Cancer 14 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung adenocarcinoma 14 | 2,716
adult high grade glioma 13 | 3,801
nasopharyngeal carcinoma 13 | 1,058
colon cancer 10 | 1,478
ductal carcinoma in situ 10 | 1,745
invasive ductal carcinoma 10 | 2,951
ependymoma 9 | 4,679
Autosomal recessive predisposition 8 | 1,442
Meier-Gorlin syndrome 8 | 10
oligodendroglioma 8 | 2,850
EAR, PATELLA, SHORT STATURE SYNDROME 7 | 7
Endometriosis 7 | 540
Seckel syndrome 7 | 34
Waldenstrons macroglobulinemia 7 | 765
astrocytoma 7 | 1,146
Small head 6 | 374
pediatric high grade glioma 6 | 1,064
Atopic dermatitis 5 | 952
Cryptorchidism 5 | 296
Fetal Growth Retardation 5 | 189
Hypoplastic mandible condyle 5 | 275
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Isolated growth hormone deficiency 5 | 30
Kidney cancer 5 | 2,613
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Multiple myeloma 5 | 1,332
primary Sjogren syndrome 5 | 735
Birth length less than 3rd percentile 4 | 6
Congenital small ears 4 | 48
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
Microstomia 4 | 78
Pediatric failure to thrive 4 | 365
Slender, gracile long tubular bones 4 | 21
breast carcinoma 4 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pancreatic cancer 4 | 2,398
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 30
Acute promyelocytic leukemia, FAB M3 3 | 11
Adenocarcinoma of pancreas 3 | 14
Astrocytoma, Pilocytic 3 | 3,081
Cognitive delay 3 | 608
Colonic Neoplasms 3 | 142
Colorectal Neoplasms 3 | 243
Congenital hypoplasia of breast 3 | 25
Deafness 3 | 198
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Dull intelligence 3 | 645
Feeding difficulties 3 | 127
Full lower lip 3 | 64
Gastroesophageal reflux disease 3 | 110
Global developmental delay 3 | 608
Heartburn 3 | 78
Hypertrophy of clitoris 3 | 40
Hypoplasia of the maxilla 3 | 66
Hypotrophic maxilla 3 | 66
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Maxillary retrognathia 3 | 66
Meningeal Leukemia 3 | 7
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Metastatic Breast Carcinoma 3 | 21
Microcephaly 3 | 166
Poor school performance 3 | 645
Prominent lower lip 3 | 64
Retrusion of upper jaw bones 3 | 66
Short stature 3 | 531
acute myeloid leukemia 3 | 783
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
Polycystic ovary syndrome 2 | 360
esophageal adenocarcinoma 2 | 737
tuberculosis 2 | 2,010

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 41 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 10 | 4,145
Kinase 2 | 634

WikiPathways Pathway

DNA Replication 42 | 42
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181