Development Level

Tbio 57 | 11,445
Tchem 22 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
hypoactivity 2 | 132
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye pigmentation 1 | 3
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal inner nuclear... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
female infertility 1 | 60
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased thermal nociceptive ... 1 | 9
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 63 | 11,493
ovarian cancer 60 | 8,520
Cancer 51 | 2,499
lung cancer 44 | 4,740
group 3 medulloblastoma 43 | 4,104
osteosarcoma 43 | 7,950
glioblastoma 41 | 5,792
medulloblastoma, large-cell 41 | 6,241
psoriasis 40 | 6,694
atypical teratoid / rhabdoid tumor 37 | 5,112
malignant mesothelioma 37 | 3,232
Breast cancer 36 | 3,578
primitive neuroectodermal tumor 32 | 3,035
non-small cell lung cancer 26 | 2,890
ependymoma 24 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Kidney cancer 22 | 2,613
invasive ductal carcinoma 22 | 2,951
adult high grade glioma 20 | 3,801
Autosomal recessive predisposition 19 | 1,442
breast carcinoma 19 | 1,638
lung adenocarcinoma 19 | 2,716
Fanconi anemia 18 | 56
colon cancer 18 | 1,478
ductal carcinoma in situ 18 | 1,745
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
Intellectual disability 16 | 1,016
Nijmegen breakage syndrome 16 | 24
Short stature 16 | 531
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Ataxia telangiectasia 15 | 34
Bloom syndrome 15 | 29
Xeroderma pigmentosum 14 | 43
adrenocortical carcinoma 14 | 1,428
nasopharyngeal carcinoma 14 | 1,058
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Small head 13 | 374
oligodendroglioma 13 | 2,850
Pick disease 12 | 1,894
Waldenstrons macroglobulinemia 12 | 765
Werner syndrome 12 | 29
diabetes mellitus 12 | 1,728
Anemia 11 | 365
Endometriosis 11 | 540
Prostatic Neoplasms 11 | 495
Schizophrenia 11 | 1,160
pituitary cancer 11 | 1,972
ulcerative colitis 11 | 1,819
Hereditary Breast and Ovarian Cancer Syndrome 10 | 14
pancreatic cancer 10 | 2,398
Chromosome Breakage 9 | 36
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
acute quadriplegic myopathy 9 | 1,158
astrocytic glioma 9 | 2,597
astrocytoma 9 | 1,146
subependymal giant cell astrocytoma 9 | 2,287
Acquired scoliosis 8 | 281
Astrocytoma, Pilocytic 8 | 3,081
Curvature of spine 8 | 282
Leukemia 8 | 104
Malignant neoplasm of breast 8 | 15
Melanoma 8 | 711
Thrombocytopenia 8 | 197
dermatomyositis 8 | 966
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Atopic dermatitis 7 | 952
Attention deficit hyperactivity disorder 7 | 278
Decreased platelet count 7 | 111
Increased chromosomal breakage 7 | 27
Seckel syndrome 7 | 34
Strabismus 7 | 270
hypopigmented skin patch 7 | 59
juvenile dermatomyositis 7 | 1,187
Adenoid Cystic Carcinoma 6 | 99
Carcinoma, Adenoid Cystic 6 | 99
Cockayne syndrome 6 | 60
Colonic Neoplasms 6 | 142
Colorectal Neoplasms 6 | 243
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Glioma 6 | 74
Leukopenia 6 | 72
Lung Neoplasms 6 | 232
Lymphoma 6 | 81
Lynch syndrome 6 | 35
Microcephaly 6 | 166
Multiple myeloma 6 | 1,332
Pancreatic Neoplasm 6 | 85
Rheumatoid arthritis 6 | 1,191
Seizures 6 | 596
lung carcinoma 6 | 2,843
medulloblastoma 6 | 720
pediatric high grade glioma 6 | 1,064

Tissue

Blood and immune system 79 | 16,909
Digestive Tract 79 | 17,369
Endocrine System 79 | 18,159
Female tissues 79 | 17,400
Liver and Pancreas 79 | 16,750
Male tissues 79 | 17,142
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Skin and soft tissues 79 | 17,230
Urinary Tract 79 | 16,678
Cardiovascular System 78 | 15,192

Target Family

Non-IDG 44 | 12,091
Enzyme 19 | 4,145
Kinase 9 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
TF/Epigenetic 1 | 38

WikiPathways Pathway

DNA IR-damage and cellular res... 80 | 80
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.09041 139.4 210
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Eukaryotic translation elongation factor 1 epsilon-1 EEF1E1 Tbio Non-IDG -1.01041 12.5 141
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -1.08250 13.0 123