Development Level

Tbio 53 | 10,625
Tchem 53 | 1,890
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 633
abnormal lens morphology 3 | 73
cataract 3 | 26
decreased body weight 3 | 174
increased circulating alkaline... 3 | 119
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal startle reflex 2 | 14
abnormal testis morphology 2 | 30
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating sodium l... 2 | 18
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased mean corpuscular hem... 2 | 93
short tibia 2 | 82
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
absent heartbeat 1 | 6
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased prepulse inhibition 1 | 52
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased B cell number 1 | 23
increased circulating LDL chol... 1 | 15
increased circulating free fat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
syndactyly 1 | 4
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

Cancer 80 | 2,346
ovarian cancer 79 | 8,491
osteosarcoma 64 | 7,933
psoriasis 62 | 6,685
glioblastoma 49 | 5,572
medulloblastoma, large-cell 47 | 6,234
lung cancer 44 | 4,473
atypical teratoid / rhabdoid tumor 41 | 4,369
Breast cancer 39 | 3,098
Carcinoma 33 | 2,147
malignant mesothelioma 33 | 3,163
pancreatic cancer 31 | 2,300
invasive ductal carcinoma 29 | 2,950
diabetes mellitus 28 | 1,663
ulcerative colitis 27 | 2,087
Prostatic Neoplasms 26 | 471
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
ependymoma 24 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,956
pediatric high grade glioma 23 | 2,712
pilocytic astrocytoma 23 | 3,086
Mammary Neoplasms 22 | 410
oligodendroglioma 22 | 2,849
astrocytoma 21 | 1,493
group 4 medulloblastoma 21 | 1,875
non-small cell lung cancer 21 | 2,798
primitive neuroectodermal tumor 21 | 3,031
subependymal giant cell astrocytoma 21 | 2,287
interstitial cystitis 20 | 2,299
lung adenocarcinoma 20 | 2,714
lung carcinoma 20 | 2,844
Adenoma 19 | 165
Stomach Neoplasms 19 | 282
Vascular disease 19 | 281
juvenile dermatomyositis 19 | 1,189
primary pancreatic ductal adenocarcinoma 19 | 1,271
Lung Neoplasms 18 | 171
adult high grade glioma 18 | 2,148
ductal carcinoma in situ 18 | 1,745
pituitary cancer 18 | 1,972
tuberculosis 18 | 1,563
Colonic Neoplasms 17 | 126
Liver carcinoma 17 | 217
Multiple myeloma 17 | 1,327
Rheumatoid Arthritis 17 | 1,170
astrocytic glioma 17 | 2,241
pancreatic carcinoma 17 | 567
Neoplastic Cell Transformation 16 | 81
acute quadriplegic myopathy 16 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
medulloblastoma 16 | 1,524
Adenocarcinoma 15 | 115
Obesity 15 | 616
cystic fibrosis 15 | 1,670
hepatocellular carcinoma 15 | 550
Alzheimer's disease 14 | 644
breast carcinoma 14 | 1,614
dermatomyositis 14 | 966
nasopharyngeal carcinoma 14 | 1,056
non-small cell lung carcinoma 14 | 413
Colorectal Neoplasms 13 | 217
Neoplasm Metastasis 13 | 138
Pick disease 13 | 1,893
Waldenstrons macroglobulinemia 13 | 764
chronic lymphocytic leukemia 13 | 244
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
posterior fossa group A ependymoma 13 | 1,511
Osteoporosis 12 | 259
colon cancer 12 | 1,475
cutaneous lupus erythematosus 12 | 1,056
group 3 medulloblastoma 12 | 2,254
ovarian neoplasm 12 | 97
Kidney cancer 11 | 121
Melanoma 11 | 261
Parkinson's disease 11 | 364
Peripheral Neuropathy 11 | 303
adrenocortical carcinoma 11 | 1,427
gastric cancer 11 | 436
Diabetes Mellitus, Non-Insulin-Dependent 10 | 161
Familial adenomatous polyposis 10 | 33
Kidney disease 10 | 397
Neoplasm Invasiveness 10 | 127
Pancreatic Neoplasm 10 | 79
Papilloma 10 | 27
Reperfusion Injury 10 | 84
Schizophrenia 10 | 503
atypical teratoid/rhabdoid tumor 10 | 1,095
posterior fossa group B ependymoma 10 | 1,530
primary Sjogren syndrome 10 | 788
sonic hedgehog group medulloblastoma 10 | 1,482
spina bifida 10 | 1,064
Amyotrophic Lateral Sclerosis 9 | 432
Asthma 9 | 349
Autistic Disorder 9 | 320
Bladder Neoplasm 9 | 109
Brain Ischemia 9 | 87
IGA Glomerulonephritis 9 | 454
Liver neoplasms 9 | 108
Squamous cell carcinoma 9 | 96
gastric carcinoma 9 | 832

Tissue

Digestive Tract 111 | 18,472
Endocrine System 111 | 18,511
Female tissues 111 | 18,646
Liver and Pancreas 111 | 18,135
Nervous System 111 | 18,560
Respiratory system 111 | 17,483
Urinary Tract 111 | 18,443
Blood and immune system 110 | 17,994
Male tissues 110 | 17,968
Skin and soft tissues 110 | 18,114
Cardiovascular System 109 | 17,957

Target Family

Non-IDG 46 | 11,969
Kinase 28 | 634
Enzyme 22 | 4,146
Transcription Factor 16 | 1,400

WikiPathways Pathway

DNA Damage Response (only ATM ... 112 | 112
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.14287 1340.6 903
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265