Development Level

Tbio 64 | 11,651
Tchem 41 | 1,388
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal heart morphology 4 | 162
increased mean corpuscular hem... 4 | 96
short tibia 4 | 97
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
decreased grip strength 2 | 116
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating free fat... 2 | 20
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 36
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean platelet volume 1 | 25
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased circulating LDL chol... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
small heart 1 | 10
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 92 | 11,493
Cancer 82 | 2,499
ovarian cancer 80 | 8,520
osteosarcoma 64 | 7,950
psoriasis 62 | 6,694
glioblastoma 54 | 5,792
lung cancer 51 | 4,740
atypical teratoid / rhabdoid tumor 50 | 5,112
medulloblastoma, large-cell 47 | 6,241
Breast cancer 45 | 3,578
ependymoma 39 | 4,679
malignant mesothelioma 35 | 3,232
pancreatic cancer 33 | 2,398
Kidney cancer 31 | 2,613
adult high grade glioma 30 | 3,801
diabetes mellitus 29 | 1,728
invasive ductal carcinoma 29 | 2,951
group 3 medulloblastoma 28 | 4,104
Prostatic Neoplasms 27 | 495
Schizophrenia 26 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Breast Neoplasms 24 | 445
astrocytic glioma 24 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
Astrocytoma, Pilocytic 22 | 3,081
Mammary Neoplasms 22 | 425
Stomach Neoplasms 22 | 300
oligodendroglioma 22 | 2,850
tuberculosis 22 | 2,010
ulcerative colitis 22 | 1,819
Vascular disease 21 | 319
breast carcinoma 21 | 1,638
non-small cell lung cancer 21 | 2,890
primitive neuroectodermal tumor 21 | 3,035
subependymal giant cell astrocytoma 21 | 2,287
Lung Neoplasms 20 | 232
group 4 medulloblastoma 20 | 1,855
interstitial cystitis 20 | 2,312
lung adenocarcinoma 20 | 2,716
lung carcinoma 20 | 2,843
Adenoma 19 | 167
Liver carcinoma 19 | 240
juvenile dermatomyositis 19 | 1,187
Autosomal recessive predisposition 18 | 1,442
Carcinoma, Hepatocellular 18 | 228
Cell Transformation, Neoplastic 18 | 97
Colonic Neoplasms 18 | 142
Multiple myeloma 18 | 1,332
Obesity 18 | 678
ductal carcinoma in situ 18 | 1,745
pituitary cancer 18 | 1,972
Adenocarcinoma 17 | 122
Lymphoid leukemia 17 | 160
Neoplastic Cell Transformation 17 | 89
Orbital separation excessive 17 | 244
Rheumatoid arthritis 17 | 1,191
primary pancreatic ductal adenocarcinoma 17 | 1,109
Neoplasm Metastasis 16 | 168
acute quadriplegic myopathy 16 | 1,158
astrocytoma 16 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Hypoplastic mandible condyle 15 | 275
Immune system cancer 15 | 140
Intellectual disability 15 | 1,016
Liver cancer 15 | 604
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Seizures 15 | 596
Short stature 15 | 531
Splenomegaly 15 | 190
cystic fibrosis 15 | 1,696
hepatocellular carcinoma 15 | 547
pancreatic carcinoma 15 | 562
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Alzheimer's disease 14 | 658
Epilepsy 14 | 792
Melanoma 14 | 711
Osteoporosis 14 | 363
dermatomyositis 14 | 966
nasopharyngeal carcinoma 14 | 1,058
Cognitive delay 13 | 608
Colorectal Neoplasms 13 | 243
Dull intelligence 13 | 645
Global developmental delay 13 | 608
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Ovarian Neoplasms 13 | 102
Pick disease 13 | 1,894
Poor school performance 13 | 645
Squamous cell carcinoma 13 | 129
Waldenstrons macroglobulinemia 13 | 765
Bipolar Disorder 12 | 666
Byzanthine arch palate 12 | 194
Chronic Lymphocytic Leukemia 12 | 262
Hypertensive disease 12 | 292
Pancreatic Neoplasm 12 | 85
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057

Tissue

Digestive Tract 109 | 17,369
Female tissues 109 | 17,400
Blood and immune system 108 | 16,909
Endocrine System 108 | 18,159
Liver and Pancreas 108 | 16,750
Male tissues 108 | 17,142
Nervous System 108 | 16,725
Skin and soft tissues 108 | 17,230
Urinary Tract 108 | 16,678
Respiratory system 106 | 16,393
Cardiovascular System 99 | 15,192

Target Family

Non-IDG 46 | 12,091
Kinase 28 | 634
Enzyme 22 | 4,145
Transcription Factor 16 | 1,400

WikiPathways Pathway

DNA Damage Response (only ATM ... 112 | 112
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Tbio Enzyme -1.52582 28.6 325
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.33238 204.8 739
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355