Development Level

Tbio 27 | 11,445
Tchem 6 | 1,598
Tclin 5 | 613

IMPC Phenotype

enlarged heart 2 | 210
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
decreased bone mineral content 1 | 151
decreased circulating creatini... 1 | 39
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased erythrocyte cell num... 1 | 39
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
limb grasping 1 | 41
male infertility 1 | 123

Disease

Rheumatoid arthritis 24 | 1,191
sarcoidosis 24 | 370
Cancer 22 | 2,499
Hypersensitivity reaction type II disease 18 | 253
Inflammatory bowel disease 17 | 151
Multiple Sclerosis 17 | 540
psoriasis 17 | 6,694
Asthma 16 | 385
Berylliosis 16 | 28
tuberculosis 16 | 2,010
Arthritis 15 | 290
Systemic lupus erythematosus 15 | 194
malignant mesothelioma 15 | 3,232
Narcolepsy 14 | 72
Rheumatoid Arthritis, Systemic Juvenile 14 | 16
diabetes mellitus 14 | 1,728
Diffuse cutaneous systemic sclerosis 13 | 17
Lung disease 13 | 142
Multiple Sclerosis, Susceptibility to 13 | 15
Narcolepsy-cataplexy 13 | 21
Pulmonary Fibrosis 13 | 106
Sarcoidosis 1 13 | 14
Schizophrenia 13 | 1,160
follicular lymphoma 13 | 20
limited scleroderma 13 | 19
Pneumonia 12 | 174
Allergic hypersensitivity disease 11 | 126
Anemia 11 | 365
Dermatitis 11 | 157
Hepatitis B 11 | 108
Hypereosinophilic syndrome 11 | 71
Leukopenia 11 | 72
lung cancer 11 | 4,740
lung carcinoma 11 | 2,843
Allergic rhinitis 10 | 94
Breast Neoplasms 10 | 445
Chemical and Drug Induced Liver Injury 10 | 195
Fever 10 | 138
Inflammation 10 | 120
Influenza 10 | 142
Leishmaniasis 10 | 47
Liver disease 10 | 237
Mammary Neoplasms 10 | 425
Vasculitis 10 | 80
ulcerative colitis 10 | 1,819
Autistic Disorder 9 | 364
Carcinoma 9 | 11,493
Collagen disease 9 | 27
Crohn's disease 9 | 321
Hepatitis, Autoimmune 9 | 17
Hypersensitivity 9 | 63
Kidney disease 9 | 430
Leprosy 9 | 73
Malaria 9 | 160
Neuropathy 9 | 261
Tetanus 9 | 68
Thrombocytopenia 9 | 197
cystic fibrosis 9 | 1,696
glioblastoma 9 | 5,792
periodontitis 9 | 293
Acquired immunodeficiency syndrome 8 | 197
Arthritis, Rheumatoid 8 | 174
Brain Injuries 8 | 65
Dermatitis, Allergic Contact 8 | 67
Diarrhea 8 | 253
Heart disease 8 | 306
Hepatitis C 8 | 94
Liver Cirrhosis, Experimental 8 | 769
interstitial cystitis 8 | 2,312
Arthritis, Experimental 7 | 39
Atherosclerosis 7 | 291
Bipolar Disorder 7 | 666
Breast cancer 7 | 3,578
Candidiasis 7 | 55
Colitis 7 | 54
Common cold 7 | 67
Dermatitis, Atopic 7 | 37
Heart failure 7 | 162
Leishmaniasis, Visceral 7 | 13
Lung Neoplasms 7 | 232
Major Depressive Disorder 7 | 301
Mesothelioma, Malignant 7 | 105
Mucositis 7 | 29
Myocardial Infarction 7 | 151
Primary immunodeficiency disease 7 | 54
Psoriatic arthritis 7 | 86
Reperfusion Injury 7 | 86
Uveitis 7 | 103
Vascular disease 7 | 319
cutaneous lupus erythematosus 7 | 1,057
Abortion, Spontaneous 6 | 109
Astrocytoma, Pilocytic 6 | 3,081
Depressive disorder 6 | 409
Endometriosis 6 | 540
Mental Depression 6 | 333
Spontaneous abortion 6 | 113
Unipolar Depression 6 | 250
Urticaria 6 | 67
adult high grade glioma 6 | 3,801
non-small cell lung cancer 6 | 2,890

Tissue

Blood and immune system 26 | 16,909
Male tissues 25 | 17,142
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Liver and Pancreas 24 | 16,750
Skin and soft tissues 24 | 17,230
Female tissues 23 | 17,400
Respiratory system 23 | 16,393
Urinary Tract 23 | 16,678
Nervous System 21 | 16,725
Cardiovascular System 16 | 15,192

Target Family

Non-IDG 38 | 12,091

WikiPathways Pathway

Cytokines and Inflammatory Res... 38 | 38
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

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